Max Krummel, PhD

Professor
Department of Pathology
+1 415 514-3130
Research Overview: 

Our work focusses on understanding patterns of immune cell-cell interactions and how these generate “the immune system”. Our studies of the immune synapse have shown how T cells regulate their motility, how they signal through synapses while moving, how they communicate with each other during arrest, and how they ‘search’ a new tissue. These are all fundamental findings and provide a lens through which we understand T cell function.

Over the past four years, we have developed novel methods and computational platforms to understand immunological processes in space and in time within normal and diseased organs. We were the first to live-image events in progressive tumors in which incoming tumor-specific T cells are captured by a population of myeloid cells. I am tremendously excited that we have begun to develop a pipeline of next-generation protein immuno-therapeutics using imaging to ‘guide’ this development.

Concurrently, we co-developed a  imaging technologies that allow, for the first time, observation of the immune system in the homeostatic, infected/injured, allergic or metastatic lung. As with primary tumors, this latter focus has allowed us to dismiss many hypothetical immune scenarios and intensely study those that define the biology in situ. 

These studies define how the immune system is organizing over space and time and guides novel therapeutic solutions.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
The Immune Response in 4 Dimensions

Websites

Publications: 

Immediate myeloid depot for SARS-CoV-2 in the human lung.

Science advances

Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Bernard O, Simoneau CR, Hysenaj L, Hu KH, Maishan M, Conrad C, Gbenedio OM, Samad B, Consortium TUC, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR

Localized in vivo gene editing of murine cancer-associated fibroblasts.

bioRxiv : the preprint server for biology

Kuhn NF, Zaleta-Linares I, Nyberg WA, Eyquem J, Krummel MF

Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.

Nature communications

Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK

Critical role of CD206+ macrophages in organizing anti-tumor immunity.

bioRxiv : the preprint server for biology

Ray A, Hu KH, Kersten K, Kuhn NF, Samad B, Combes AJ, Krummel MF

Multimodal identification of rare potent effector CD8 T cells in solid tumors.

bioRxiv : the preprint server for biology

Ray A, Bassette M, Hu KH, Pass LF, Samad B, Combes A, Johri V, Davidson B, Hernandez G, Zaleta-Linares I, Krummel MF