Max Krummel, PhD

Professor
Department of Pathology
+1 415 514-3130
Research Overview: 

Our work focusses on understanding patterns of immune cell-cell interactions and how these generate “the immune system”. Our studies of the immune synapse have shown how T cells regulate their motility, how they signal through synapses while moving, how they communicate with each other during arrest, and how they ‘search’ a new tissue. These are all fundamental findings and provide a lens through which we understand T cell function.

Over the past four years, we have developed novel methods and computational platforms to understand immunological processes in space and in time within normal and diseased organs. We were the first to live-image events in progressive tumors in which incoming tumor-specific T cells are captured by a population of myeloid cells. I am tremendously excited that we have begun to develop a pipeline of next-generation protein immuno-therapeutics using imaging to ‘guide’ this development.

Concurrently, we co-developed a  imaging technologies that allow, for the first time, observation of the immune system in the homeostatic, infected/injured, allergic or metastatic lung. As with primary tumors, this latter focus has allowed us to dismiss many hypothetical immune scenarios and intensely study those that define the biology in situ. 

These studies define how the immune system is organizing over space and time and guides novel therapeutic solutions.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
The Immune Response in 4 Dimensions

Websites

Publications: 

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response.

The Journal of experimental medicine

Tanaka M, Lum L, Hu KH, Chaudhary P, Hughes S, Ledezma-Soto C, Samad B, Superville D, Ng K, Chumber A, Benson C, Adams ZN, Kersten K, Aguilar OA, Fong L, Combes AJ, Krummel MF, Reeves MQ

Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium.

medRxiv : the preprint server for health sciences

LaHue SC, Takegami N, Simmasalam R, Baqai A, Munoz E, Sikri A, de Courson TDB, Singhal NS, Eckalbar W, Langelier CR, Hendrickson CM, Calfee CS, Erle DJ, Krummel MF, Woodruff PG, Oskotsky T, Sirota M, Ferguson A, Douglas VC, Newman JC, Pleasure SJ, Wilson MR, COMET consortium, Singhal NS

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer.

The Journal of experimental medicine

Cleary SJ, Qiu L, Seo Y, Baluk P, Liu D, Serwas NK, Taylor CA, Zhang D, Cyster JG, McDonald DM, Krummel MF, Looney MR

Multimodal identification of rare potent effector CD8 T cells in solid tumors.

bioRxiv : the preprint server for biology

Ray A, Bassette M, Hu KH, Pass LF, Samad B, Combes A, Johri V, Davidson B, Hernandez G, Zaleta-Linares I, Krummel MF

Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis.

The Journal of experimental medicine

Ray A, Hu KH, Kersten K, Courau T, Kuhn NF, Zaleta-Linares I, Samad B, Combes AJ, Krummel MF