Matt Springer, PhD

Professor
Department of Medicine
Cardiology Division
[email protected]
+1 415 502-8404
Research Description: 

RESEARCH INTERESTS:

Dr. Matthew L. Springer received his BA from the University of California, Berkeley in 1985 and his Ph.D. from Stanford University in 1992. He did postdoctoral research at Stanford and continued his research there as a senior scientist until joining the UCSF faculty in 2003, where he is currently one of the few non-clinicians on the faculty of the Division of Cardiology. The close juxtaposition of his basic research background with the clinical cardiologists in the Division has resulted in an active translational research program. Dr. Springer's research interests include cell therapy and gene therapy approaches to studying cardiovascular disease, and a major focus on the adverse effects of tobacco, marijuana, and e-cigarettes on cardiovascular function in rodents and humans.

Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
None
Research Summary: 
Angiogenesis & vascular biology, myocardial repair, endothelial function, and second hand smoke
Mentorship Development: 

5/25/21  Sharpening your Mentoring Skills (SyMS) 

Websites

Featured Publications: 

Increased vulnerability to atrial and ventricular arrhythmias caused by different types of inhaled tobacco or marijuana products.

Heart rhythm

Qiu H, Zhang H, Han DD, Derakhshandeh R, Wang X, Goyal N, Navabzadeh M, Rao P, Wilson EE, Mohammadi L, Olgin JE, Springer ML

Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels.

Arteriosclerosis, thrombosis, and vascular biology

Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML

Impairment of Endothelial Function by Cigarette Smoke Is Not Caused by a Specific Smoke Constituent, but by Vagal Input From the Airway.

Arteriosclerosis, thrombosis, and vascular biology

Nabavizadeh P, Liu J, Rao P, Ibrahim S, Han DD, Derakhshandeh R, Qiu H, Wang X, Glantz SA, Schick SF, Springer ML

Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Rao P, Han DD, Tan K, Mohammadi L, Derakhshandeh R, Navabzadeh M, Goyal N, Springer ML

JUUL and Combusted Cigarettes Comparably Impair Endothelial Function.

Tobacco regulatory science

Rao P, Liu J, Springer ML

Impaired therapeutic efficacy of bone marrow cells from post-myocardial infarction patients in the TIME and LateTIME clinical trials.

PloS one

Wang X, Chacon LI, Derakhshandeh R, Rodriguez HJ, Han DD, Kostyushev DS, Henry TD, Traverse JH, Moyé L, Simari RD, Taylor DA, Springer ML

Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke.

Tobacco control

Nabavizadeh P, Liu J, Havel CM, Ibrahim S, Derakhshandeh R, Jacob Iii P, Springer ML

Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.

Molecular therapy : the journal of the American Society of Gene Therapy

An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML

One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.

Journal of the American Heart Association

Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML

Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.

Journal of the American Heart Association

Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML

Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.

Science translational medicine

Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML

Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy.

Molecular therapy : the journal of the American Society of Gene Therapy

Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W

In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound.

American journal of physiology. Heart and circulatory physiology

Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML

Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography.

American journal of physiology. Heart and circulatory physiology

Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y

VEGF gene delivery to muscle: potential role for vasculogenesis in adults.

Molecular cell

Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM