Mark Looney, MD

Department of Medicine
Department of Laboratory Medicine
+1 415 476-9190
Research Description: 

Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

Research Interests

My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Research Summary: 
Mechanisms of lung inflammation and injury



(225) Novel Anti-CD94 Treatment Reduces Mouse and Human Experimental Pulmonary Ischemia-Reperfusion Injury.

The Journal of Heart and Lung Transplantation

T. Tsao, L. Qiu, A. Shemesh, A. Millan Hernandez, K. Shi, J. Richardson, R. Bharti, J. Santos, L. Lanier, M. Looney, J. Greenland, D.R. Calabrese

IgG hexamers initiate complement-dependent acute lung injury.

The Journal of clinical investigation

Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR

Functional haematopoietic progenitor cells in the adult human lung.

Research square

Looney M, Conrad C, Magnen M, Tsui J, Wismer H, Naser M, Venkataramani U, Samad B, Cleary S, Qiu L, Tian J, De Giovanni M, Mende N, Passegue E, Laurenti E, Combes A

IgG hexamers initiate acute lung injury.

bioRxiv : the preprint server for biology

Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AEH, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR

MICB Genomic Variant is Associated with NKG2D-mediated Acute Lung Injury and Death.

American journal of respiratory and critical care medicine

Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR, LTOG Investigators