Mark Looney, MD

Professor
Department of Medicine
Department of Laboratory Medicine
+1 415 476-9190
Research Description: 

Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

Research Interests

My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Immunology
Research Summary: 
Mechanisms of lung inflammation and injury

Websites

Publications: 

Complement activation on endothelium initiates antibody-mediated acute lung injury.

The Journal of clinical investigation

Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR

NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.

Transfusion

Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL

Targeting potential drivers of COVID-19: Neutrophil extracellular traps.

The Journal of experimental medicine

Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M

Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.

British journal of pharmacology

Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP

Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.

The Journal of clinical investigation

Ortiz-Munoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR