Jonah Chan, PhD

Professor
Department of Neurology
+1 415 476-8557
Research Description: 

Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program, the Division of Neuroimmunology and Glial Biology and Co-Director of the Innovation Program for Remyelination and Repair at UCSF.

The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.

Current Laboratory Members:

Trung Huynh, BS
Lab Manager
[email protected]

Sonia Mayoral, PhD
Postdoctoral Fellow
[email protected]

Kae-Jiun Chang, PhD
Postdoctoral Fellow
[email protected]

Lindsay Osso, BS
Graduate Student
[email protected]

Sarah Raissi, PhD
Postdoctoral Fellow
[email protected]

Maggie Yeung, PhD
Postdoctoral Fellow
[email protected]

Wendy Xin, PhD
Postdoctoral Fellow
[email protected]

Monique Lillis, BS
Graduate Student
[email protected]

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Neuronal/Glial Interactions that Control Myelination

Websites

Publications: 

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.

Nature neuroscience

Wang F, Ren SY, Chen JF, Liu K, Li RX, Li ZF, Hu B, Niu JQ, Xiao L, Chan JR, Mei F

Preservation of a remote fear memory requires new myelin formation.

Nature neuroscience

Pan S, Mayoral SR, Choi HS, Chan JR, Kheirbek MA

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7.

Nature communications

Harty BL, Coelho F, Pease-Raissi SE, Mogha A, Ackerman SD, Herbert AL, Gereau RW, Golden JP, Lyons DA, Chan JR, Monk KR

A surprising role for myelin in Williams syndrome.

Nature neuroscience

Osso LA, Chan JR