Jonah Chan, PhD

Professor
Department of Neurology
+1 415 476-8557
Research Description: 

Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program, Vice Chief in the Division of Neuroimmunology and Glial Biology and Co-Director of the Innovation Program for Remyelination and Repair at UCSF.

The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.

Current Laboratory Members:

Trung Huynh, BS
Lab Manager
[email protected]

Sarah Raissi, PhD
Postdoctoral Fellow
[email protected]

Wendy Xin, PhD
Postdoctoral Fellow
[email protected]

Monique Lillis, BS
Graduate Student
[email protected]

Albert Zhang, PhD
Postdoctoral Fellow
[email protected]

Sonia Nocera, PhD
Postdoctoral Fellow
[email protected]

Sandy Chu, BA
Research Assistant
[email protected]

Lahin Lalani, BS
Graduate Student
[email protected]

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Neuronal/Glial Interactions that Control Myelination

Websites

Publications: 

Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis.

Journal of neurology, neurosurgery, and psychiatry

Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ

Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy.

Brain : a journal of neurology

Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ

A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial.

Multiple sclerosis and related disorders

Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ

Metabolic control of sensory neuron survival by the p75 neurotrophin receptor in Schwann cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Follis RM, Tep C, Genaro-Mattos TC, Kim ML, Ryu JC, Morrison VE, Chan JR, Porter N, Carter BD, Yoon SO