Jeffrey Bush, PhD

Associate Professor
Department of Cell & Tissue Biology
+1 415 476-9459
Research Overview: 

Our lab studies basic mechanisms by which signaling between cells coordinates morphogenesis. Understanding this control has significance beyond its fundamental importance in development since birth defects are the leading cause of death for infants during the first year of life. Craniofacial anomalies are the most common class of congenital defect in humans, with three quarters of all malformations identified at birth involving craniofacial dysmorphogenesis.  We utilize multiple approaches based in mouse genetics to understand fundamental signaling processes as they relate to craniofacial development and disease. In addition to mouse genetics approaches, we utilize human induced pluripotent stem cells and live imaging to understand the cellular and molecular control of morphogenesis.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Signaling control of craniofacial development and congenital disease

Websites

Publications: 

Delineating the early transcriptional specification of the mammalian trachea and esophagus.

eLife

Kuwahara A, Lewis AE, Coombes C, Leung FS, Percharde M, Bush JO

The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice within a Research Community.

G3 (Bethesda, Md.)

Wall E, Scoles J, Joo A, Klein O, Quinonez C, Bush JO, Martin GR, Laird DJ

Cellular organization and boundary formation in craniofacial development.

Genesis (New York, N.Y. : 2000)

Kindberg AA, Bush JO