Jacquelyn Maher, MD

Department of Medicine - Gastroenterology
Research Overview: 

Our laboratory studies basic biological processes relevant to liver biology and disease. Our main focus is on nonalcoholic fatty liver disease (NAFLD), which affects 25% of the world’s population. We have extensive experience modeling NAFLD in mouse models, but have recently redirected our research to concentrate on characterization of NAFLD disease signatures in human liver cells differentiated from iPSCs. We conduct studies on iPSC-derived liver cells from a large cohort of NAFLD and control patients, who harbor a variety of genetic variants associated with NAFLD. Our goal is to determine how genetic variants, alone and in combination, contribute to NAFLD disease phenotypes in iPSC-derived liver cell culture systems.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
NAFLD disease modeling using patient-derived iPSCs



Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease.

Magnetic resonance in medicine

Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA

A genetic basis of mitochondrial DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma.

Hepatology (Baltimore, Md.)

Chang CW, Chen YS, Huang CH, Lin CH, Ng WV, Chu LJ, Trépo E, Zucman-Rossi J, Siao K, Maher JJ, Chiew MY, Chou CH, Huang HD, Teo WH, Lee IS, Lo JF, Wang XW

Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.

Nature communications

Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H

Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.

medRxiv : the preprint server for health sciences

Klepper A, Kung A, Vazquez SE, Mitchell A, Mann S, Zorn K, Avila-Vargas I, Kari S, Tekeste M, Castro J, Lee B, Duarte M, Khalili M, Yang M, Wolters P, Price J, Perito E, Feng S, Maher JJ, Lai J, Weiler-Normann C, Lohse AW, DeRisi J, Tana M

The Role of STING in Liver Injury Is Both Stimulus- and Time-Dependent.


Siao K, Le Guillou D, Maher JJ, Duwaerts CC