Esteban G. Burchard, MD, MPH

Department of Bioengineering and Therapeutic Sciences
+1 415 514-9677
Research Description: 

Asthma is the most common chronic disease among children affecting Puerto Rican and African American children more than other races/ethnicities. We study the interplay between genes and the environment to determine the root causes of asthma health disparities in children and adolescents to identify and develop targeted interventions to improve asthma outcomes. The complexities of asthma and respiratory disease require a multi-disciplinary approach. I, therefore, cultivated and maintained over 20 years a network of collaborators with expertise in epidemiology, biostatistics, medicine, molecular and cell biology, and genomics to perform comprehensive research in this area. Together, we are working to ensure that modern advances in genomics will benefit all populations.

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Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Research Summary: 
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases



Population sequencing data reveal a compendium of mutational processes in the human germ line.

Science (New York, N.Y.)

Seplyarskiy VB, Soldatov RA, Koch E, McGinty RJ, Goldmann JM, Hernandez RD, Barnes K, Correa A, Burchard EG, Ellinor PT, McGarvey ST, Mitchell BD, Vasan RS, Redline S, Silverman E, Weiss ST, Arnett DK, Blangero J, Boerwinkle E, He J, Montgomery C, Rao DC, Rotter JI, Taylor KD, Brody JA, Chen YI, de Las Fuentes L, Hwu CM, Rich SS, Manichaikul AW, Mychaleckyj JC, Palmer ND, Smith JA, Kardia SLR, Peyser PA, Bielak LF, O'Connor TD, Emery LS, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium , TOPMed Population Genetics Working Group , Gilissen C, Wong WSW, Kharchenko PV, Sunyaev S

Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma.

Journal of personalized medicine

Hernandez-Pacheco N, Gorenjak M, Li J, Repnik K, Vijverberg SJ, Berce V, Jorgensen A, Karimi L, Schieck M, Samedy-Bates LA, Tavendale R, Villar J, Mukhopadhyay S, Pirmohamed M, Verhamme KMC, Kabesch M, Hawcutt DB, Turner S, Palmer CN, Tantisira KG, Burchard EG, Maitland-van der Zee AH, Flores C, Potocnik U, Pino-Yanes M

ADRB2 Haplotypes and Asthma Exacerbations in Children and Young Adults: An Individual Participant Data Meta-Analysis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Karimi L, Vijverberg SJ, Engelkes M, Hernandez-Pacheco N, Farzan N, Soares P, Pino-Yanes M, Jorgensen AL, Eng C, Mukhopadhyay S, Schieck M, Kabesch M, Burchard EG, Chew FT, Sio YY, Potocnik U, Gorenjak M, Hawcutt DB, Palmer CN, Turner S, Janssens HM, Maitland-van der Zee AH, Verhamme KMC, PiCA, SysPharmPedia consortia

Office of Management and Budget Racial/Ethnic Categories in Mortality Research: A Framework for Including the Voices of Racialized Communities.

American journal of public health

Hayes-Bautista DE, Bryant M, Yudell M, Hayes-Bautista TM, Partlow K, Popejoy AB, Burchard E, Hsu P

Robust, flexible, and scalable tests for Hardy-Weinberg Equilibrium across diverse ancestries.


Kwong AM, Blackwell TW, LeFaive J, de Andrade M, Barnard J, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Cade BE, Chasman DI, Chen H, Conomos MP, Cupples LA, Ellinor PT, Eng C, Gao Y, Guo X, Ryan Irvin M, Kelly TN, Kim W, Kooperberg C, Lubitz SA, Mak ACY, Manichaikul AW, Mathias RA, Montasser ME, Montgomery CG, Musani S, Palmer ND, Peloso GM, Qiao D, Reiner AP, Roden DM, Shoemaker MB, Smith JA, Smith NL, Lasky Su J, Tiwari HK, Weeks DE, Weiss ST, NHLBI Trans-Omics for Precision Medicine
(TOPMed) Consortium, TOPMed Analysis Working Group , Scott LJ, Smith AV, Abecasis GR, Boehnke M, Min Kang H