Esteban G. Burchard, MD, MPH

Department of Bioengineering and Therapeutic Sciences
+1 415 514-9677
Research Description: 

Esteban González Burchard, M.D., M.P.H. is a UCSF Distinguished, Endowed, Tenured Professor of Pharmacy and Medicine. He is a Pulmonary & Critical Care Physician-Scientist trained in Genetics, Immunology, Epidemiology, Pharmacogenetics, and phase 1 clinical trials.

I am passionate about understanding why and how the risk of disease and drug response vary by race and genetic ancestry.

I led a diverse international cross-functional team of ~ 60 physicians, pharmacists, and scientists to elucidate this empiric clinical and biomedical question.

I spearheaded cross-sectional and longitudinal clinical studies in racially/ethnically diverse populations. This effort required establishing national and international physician-scientist networks, community, stakeholder, patient engagement, pre- and post-study launch strategies, execution, management, and analysis.

We collected clinical, social, and environmental data from more than 16,000 African American, Puerto Rican, and Mexican participants. I directed incorporating clinical and biomedical data from minority populations for large-scale data analysis, technology, and AI development. I have more than 370 peer-reviewed publications, 100% focused on minority populations, and generated over $100 million dollars to study racial, ethnic, and genetic ancestry differences in disease risk and drug response.

I provided the NIH and the global scientific community with the most racially diverse clinical and biological data from African American, Puerto Rican, and Mexican populations worldwide. Results from these data have placed us at the epicenter of the international debate on race and genetic ancestry in medicine.

I have outstanding oral and written communication skills and can effectively communicate complex and racially significant clinical and scientific concepts.

I am committed to leveraging my belief in leadership, teamwork, and resiliency to contribute to clinical and biomedical research.

This body of work epitomizes my ongoing drive to use science to improve the care of minority patients and mentorship of physicians, scientists, and students to improve diversity, equity, and inclusion in science and medicine.

Visit my lab page to learn more:

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Research Summary: 
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases



A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.

Cell genomics

de Smith AJ, Wahlster L, Jeon S, Kachuri L, Black S, Langie J, Cato LD, Nakatsuka N, Chan TF, Xia G, Mazumder S, Yang W, Gazal S, Eng C, Hu D, Burchard EG, Ziv E, Metayer C, Mancuso N, Yang JJ, Ma X, Wiemels JL, Yu F, Chiang CWK, Sankaran VG

Novel insights into the whole blood DNA methylome of asthma in ethnically diverse children and youth.

The European respiratory journal

Herrera-Luis E, de la Rosa-Baez C, Huntsman S, Eng C, Beckman KB, Lenoir MA, Rodriguez-Santana J, Villar J, Laprise C, Borrell LN, Ziv E, Burchard EG, Pino-Yanes M

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.

Nature communications

Budu-Aggrey A, Kilanowski A, Sobczyk MK, 23andMe Research Team, Shringarpure SS, Mitchell R, Reis K, Reigo A, Estonian Biobank Research Team, Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-Navais P, Flatley C, Espuela-Ortiz A, Herrera-Luis E, Lominchar JVT, Bork-Jensen J, Marenholz I, Arnau-Soler A, Jeong A, Fawcett KA, Baurecht H, Rodriguez E, Alves AC, Kumar A, Sleiman PM, Chang X, Medina-Gomez C, Hu C, Xu CJ, Qi C, El-Heis S, Titcombe P, Antoun E, Fadista J, Wang CA, Thiering E, Wu B, Kress S, Kothalawala DM, Kadalayil L, Duan J, Zhang H, Hadebe S, Hoffmann T, Jorgenson E, Choquet H, Risch N, Njølstad P, Andreassen OA, Johansson S, Almqvist C, Gong T, Ullemar V, Karlsson R, Magnusson PKE, Szwajda A, Burchard EG, Thyssen JP, Hansen T, Kårhus LL, Dantoft TM, Jeanrenaud ACSN, Ghauri A, Arnold A, Homuth G, Lau S, Nöthen MM, Hübner N, Imboden M, Visconti A, Falchi M, Bataille V, Hysi P, Ballardini N, Boomsma DI, Hottenga JJ, Müller-Nurasyid M, Ahluwalia TS, Stokholm J, Chawes B, Schoos AM, Esplugues A, Bustamante M, Raby B, Arshad S, German C, Esko T, Milani LA, Metspalu A, Terao C, Abuabara K, Løset M, Hveem K, Jacobsson B, Pino-Yanes M, Strachan DP, Grarup N, Linneberg A, Lee YA, Probst-Hensch N, Weidinger S, Jarvelin MR, Melén E, Hakonarson H, Irvine AD, Jarvis D, Nijsten T, Duijts L, Vonk JM, Koppelmann GH, Godfrey KM, Barton SJ, Feenstra B, Pennell CE, Sly PD, Holt PG, Williams LK, Bisgaard H, Bønnelykke K, Curtin J, Simpson A, Murray C, Schikowski T, Bunyavanich S, Weiss ST, Holloway JW, Min JL, Brown SJ, Standl M, Paternoster L

Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.

Clinical epigenetics

Perez-Garcia J, Pino-Yanes M, Plender EG, Everman JL, Eng C, Jackson ND, Moore CM, Beckman KB, Medina V, Sharma S, Winnica DE, Holguin F, Rodríguez-Santana J, Villar J, Ziv E, Seibold MA, Burchard EG