Esteban G. Burchard, MD, MPH

Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 514-9677
Research Description: 

Esteban González Burchard, M.D., M.P.H.
Distinguished, Endowed, Tenured Professor of Medicine and Pharmacy
University of California, San Francisco

Dr. Esteban González Burchard is a Pulmonary and Critical Care Physician-Scientist with expertise in Internal Medicine, Pulmonary Medicine, Critical Care, Public Health, Genetics, Epidemiology, Pharmacogenetics, and early-phase clinical trials. He cared for complex, low-income, and diverse patients at San Francisco General Hospital, focusing on expanding our understanding of how variation in disease risk and drug response differs among racially and ethnically diverse children with asthma.

As the founder and director of the UCSF Asthma Collaboratory, Dr. Burchard led a diverse team of over 60 scientists and clinicians to build the largest and most comprehensive gene-environment study of asthma in African American, Puerto Rican, and Mexican children. His research integrated clinical, social, and environmental data from over 16,000 participants, advancing the use of minority population data in large-scale analyses, technology, and artificial intelligence.

Dr. Burchard has authored more than 370 peer-reviewed publications and secured over $100 million in research funding to investigate racial, ethnic, and genetic ancestry differences in disease risk and drug response. His work has provided the NIH and the global scientific community with the most racially diverse clinical and biological datasets, driving critical debates on race and genetic ancestry in medicine.

Dr. Burchard is a dedicated mentor who has supported diverse physicians, scientists, and students, fostering equity and inclusion in science and medicine. His research and leadership have transformed care for minority populations and set new standards for diversity in biomedical research.

Visit my lab page to learn more: https://pharm.ucsf.edu/burchard.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
None
Research Summary: 
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases

Websites

Publications: 

African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1.

Nature structural & molecular biology

Álvarez Jerez P, Wild Crea P, Ramos DM, Gustavsson EK, Radefeldt M, Damianov A, Makarious MB, Ojo OO, Billingsley KJ, Malik L, Daida K, Bromberek S, Hu F, Schneider Z, Surapaneni AL, Stadler J, Rizig M, Morris HR, Pantazis CB, Leonard HL, Screven L, Qi YA, Nalls MA, Bandres-Ciga S, Hardy J, Houlden H, Eng C, Burchard EG, Kachuri L, Lin CH, Black DL, Global Parkinson’s Genetics Program (GP2), Singleton AB, Fischer S, Bauer P, Reed X, Ryten M, Beetz C, Ward M, Okubadejo NU, Blauwendraat C

Epigenetic patient stratification via contrastive machine learning refines hallmark biomarkers in minoritized children with asthma.

Research square

Gorla A, Witonsky J, Elhawary JR, Chen ZJ, Mefford J, Perez-Garcia J, Huntsman S, Hu D, Eng C, Woodruff PG, Sankararaman S, Ziv E, Flint J, Zaitlen N, Burchard E, Rahmani E

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.

Nature communications

Keener R, Chhetri SB, Connelly CJ, Taub MA, Conomos MP, Weinstock J, Ni B, Strober B, Aslibekyan S, Auer PL, Barwick L, Becker LC, Blangero J, Bleecker ER, Brody JA, Cade BE, Celedon JC, Chang YC, Cupples LA, Custer B, Freedman BI, Gladwin MT, Heckbert SR, Hou L, Irvin MR, Isasi CR, Johnsen JM, Kenny EE, Kooperberg C, Minster RL, Naseri T, Viali S, Nekhai S, Pankratz N, Peyser PA, Taylor KD, Telen MJ, Wu B, Yanek LR, Yang IV, Albert C, Arnett DK, Ashley-Koch AE, Barnes KC, Bis JC, Blackwell TW, Boerwinkle E, Burchard EG, Carson AP, Chen Z, Chen YI, Darbar D, de Andrade M, Ellinor PT, Fornage M, Gelb BD, Gilliland FD, He J, Islam T, Kaab S, Kardia SLR, Kelly S, Konkle BA, Kumar R, Loos RJF, Martinez FD, McGarvey ST, Meyers DA, Mitchell BD, Montgomery CG, North KE, Palmer ND, Peralta JM, Raby BA, Redline S, Rich SS, Roden D, Rotter JI, Ruczinski I, Schwartz D, Sciurba F, Shoemaker MB, Silverman EK, Sinner MF, Smith NL, Smith AV, Tiwari HK, Vasan RS, Weiss ST, Williams LK, Zhang Y, Ziv E, Raffield LM, Reiner AP, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group, Arvanitis M, Greider CW, Mathias RA, Battle A

5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function.

Frontiers in allergy

Walker MT, Bloodworth JC, Kountz TS, McCarty SL, Green JE, Ferrie RP, Campbell JA, Averill SH, Beckman KB, Grammer LC, Eng C, Avila PC, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Thyne SM, Seibold MA, Burchard EG, Kumar R, Cook-Mills JM

Implications of Race Adjustment in Lung-Function Equations.

The New England journal of medicine

Diao JA, He Y, Khazanchi R, Nguemeni Tiako MJ, Witonsky JI, Pierson E, Rajpurkar P, Elhawary JR, Melas-Kyriazi L, Yen A, Martin AR, Levy S, Patel CJ, Farhat M, Borrell LN, Cho MH, Silverman EK, Burchard EG, Manrai AK