Esteban G. Burchard, MD, MPH

Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 514-9677
Research Description: 

Esteban González Burchard, M.D., M.P.H. is a physician-scientist at the University of California, San Francisco (UCSF). Dr. Burchard has formal training and expertise in internal medicine, pulmonary and critical care medicine, epidemiology, molecular genetics, genetic and clinical research. Dr. Burchard is the Director of the UCSF Asthma Collaboratory, a large inter disciplinary research program focusing on minority children and gene-environment interactions for asthma. Dr. Burchard initiated and now directs the largest study of asthma in minority children in the U.S. Dr. Esteban González Burchard has more than 300 peer-reviewed publications.

Dr. Burchard was the first in the world to demonstrate that genetic ancestry strongly correlates with lung function in African Americans and Latinos, even after accounting for social determinants of health, including socioeconomic status, experiences of perceived discrimination, and environmental factors.

Dr. Burchard’s work provides the strongest evidence to date that clinical algorithms, such as those used in pulmonary function testing or estimating glomerular filtration rate, should adjust for genetic ancestry. This work combines the rigor of genetic ancestry determination with social factors-both of which must be considered for health professionals to do justice to all patients seeking their care. His continuous and ongoing work of over two decades provides a rigorous scientific approach to dissecting inherited and environmental influences on health outcomes; it is the exemplar of how the medical profession should approach the broad problem of considering “race” in medicine and health.

This body of work epitomizes Dr. Burchard’s ongoing drive to use science to improve the care of minority patients, mentorship of minority physicians and scientists, and improve diversity, equity and inclusion in science and medicine.

Visit my lab page to learn more: https://pharm.ucsf.edu/burchard

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
None
Research Summary: 
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases

Websites

Publications: 

Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.

Scientific reports

Joo J, Mak ACY, Xiao S, Sleiman PM, Hu D, Huntsman S, Eng C, Kan M, Diwakar AR, Lasky-Su JA, Weiss ST, Sordillo JE, Wu AC, Cloutier M, Canino G, Forno E, Celedón JC, Seibold MA, Hakonarson H, Williams LK, Burchard EG, Himes BE

Multi-ancestry genome-wide association study of asthma exacerbations.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Herrera-Luis E, Ortega VE, Ampleford EJ, Sio YY, Granell R, de Roos E, Terzikhan N, Vergara EE, Hernandez-Pacheco N, Perez-Garcia J, Martin-Gonzalez E, Lorenzo-Diaz F, Hashimoto S, Brinkman P, U-BIOPRED Study Group, Jorgensen AL, Yan Q, Forno E, Vijverberg SJ, Lethem R, Espuela-Ortiz A, Gorenjak M, Eng C, González-Pérez R, Hernández-Pérez JM, Poza-Guedes P, Sardón O, Corcuera P, Hawkins GA, Marsico A, Bahmer T, Rabe KF, Hansen G, Kopp MV, Rios R, Cruz MJ, González-Barcala FJ, Olaguibel JM, Plaza V, Quirce S, Canino G, Cloutier M, Del Pozo V, Rodriguez-Santana JR, Korta-Murua J, Villar J, Potocnik U, Figueiredo C, Kabesch M, Mukhopadhyay S, Pirmohamed M, Hawcutt DB, Melén E, Palmer CN, Turner S, Maitland-van der Zee AH, von Mutius E, Celedón JC, Brusselle G, Chew FT, Bleecker E, Meyers D, Burchard EG, Pino-Yanes M

Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes.

American journal of human genetics

Nieves-Colón MA, Badillo Rivera KM, Sandoval K, Villanueva Dávalos V, Enriquez Lencinas LE, Mendoza-Revilla J, Adhikari K, González-Buenfil R, Chen JW, Zhang ET, Sockell A, Ortiz-Tello P, Hurtado GM, Condori Salas R, Cebrecos R, Manzaneda Choque JC, Manzaneda Choque FP, Yábar Pilco GP, Rawls E, Eng C, Huntsman S, Burchard E, Ruiz-Linares A, González-José R, Bedoya G, Rothhammer F, Bortolini MC, Poletti G, Gallo C, Bustamante CD, Baker JC, Gignoux CR, Wojcik GL, Moreno-Estrada A

Methylation risk scores for childhood aeroallergen sensitization: Results from the LISA birth cohort.

Allergy

Kilanowski A, Chen J, Everson T, Thiering E, Wilson R, Gladish N, Waldenberger M, Zhang H, Celedón JC, Burchard EG, Peters A, Standl M, Hüls A

Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology.

Nature communications

Sajuthi SP, Everman JL, Jackson ND, Saef B, Rios CL, Moore CM, Mak ACY, Eng C, Fairbanks-Mahnke A, Salazar S, Elhawary J, Huntsman S, Medina V, Nickerson DA, Germer S, Zody MC, Abecasis G, Kang HM, Rice KM, Kumar R, Zaitlen NA, Oh S, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Rodríguez-Santana J, Burchard EG, Seibold MA