Esteban G. Burchard, MD, MPH

Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 514-9677
Research Description: 

Esteban González Burchard, M.D., M.P.H. is a UCSF Distinguished, Endowed, Tenured Professor of Pharmacy and Medicine. He is a Pulmonary & Critical Care Physician-Scientist trained in Genetics, Immunology, Epidemiology, Pharmacogenetics, and phase 1 clinical trials.

I am passionate about understanding why and how the risk of disease and drug response vary by race and genetic ancestry.

I led a diverse international cross-functional team of ~ 60 physicians, pharmacists, and scientists to elucidate this empiric clinical and biomedical question.

I spearheaded cross-sectional and longitudinal clinical studies in racially/ethnically diverse populations. This effort required establishing national and international physician-scientist networks, community, stakeholder, patient engagement, pre- and post-study launch strategies, execution, management, and analysis.

We collected clinical, social, and environmental data from more than 16,000 African American, Puerto Rican, and Mexican participants. I directed incorporating clinical and biomedical data from minority populations for large-scale data analysis, technology, and AI development. I have more than 370 peer-reviewed publications, 100% focused on minority populations, and generated over $100 million dollars to study racial, ethnic, and genetic ancestry differences in disease risk and drug response.

I provided the NIH and the global scientific community with the most racially diverse clinical and biological data from African American, Puerto Rican, and Mexican populations worldwide. Results from these data have placed us at the epicenter of the international debate on race and genetic ancestry in medicine.

I have outstanding oral and written communication skills and can effectively communicate complex and racially significant clinical and scientific concepts.

I am committed to leveraging my belief in leadership, teamwork, and resiliency to contribute to clinical and biomedical research.

This body of work epitomizes my ongoing drive to use science to improve the care of minority patients and mentorship of physicians, scientists, and students to improve diversity, equity, and inclusion in science and medicine.

Visit my lab page to learn more: https://pharm.ucsf.edu/burchard.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
None
Research Summary: 
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases

Websites

Publications: 

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes.

Nature communications

Keener R, Chhetri SB, Connelly CJ, Taub MA, Conomos MP, Weinstock J, Ni B, Strober B, Aslibekyan S, Auer PL, Barwick L, Becker LC, Blangero J, Bleecker ER, Brody JA, Cade BE, Celedon JC, Chang YC, Cupples LA, Custer B, Freedman BI, Gladwin MT, Heckbert SR, Hou L, Irvin MR, Isasi CR, Johnsen JM, Kenny EE, Kooperberg C, Minster RL, Naseri T, Viali S, Nekhai S, Pankratz N, Peyser PA, Taylor KD, Telen MJ, Wu B, Yanek LR, Yang IV, Albert C, Arnett DK, Ashley-Koch AE, Barnes KC, Bis JC, Blackwell TW, Boerwinkle E, Burchard EG, Carson AP, Chen Z, Chen YI, Darbar D, de Andrade M, Ellinor PT, Fornage M, Gelb BD, Gilliland FD, He J, Islam T, Kaab S, Kardia SLR, Kelly S, Konkle BA, Kumar R, Loos RJF, Martinez FD, McGarvey ST, Meyers DA, Mitchell BD, Montgomery CG, North KE, Palmer ND, Peralta JM, Raby BA, Redline S, Rich SS, Roden D, Rotter JI, Ruczinski I, Schwartz D, Sciurba F, Shoemaker MB, Silverman EK, Sinner MF, Smith NL, Smith AV, Tiwari HK, Vasan RS, Weiss ST, Williams LK, Zhang Y, Ziv E, Raffield LM, Reiner AP, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group, Arvanitis M, Greider CW, Mathias RA, Battle A

5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function.

Frontiers in allergy

Walker MT, Bloodworth JC, Kountz TS, McCarty SL, Green JE, Ferrie RP, Campbell JA, Averill SH, Beckman KB, Grammer LC, Eng C, Avila PC, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Thyne SM, Seibold MA, Burchard EG, Kumar R, Cook-Mills JM

Implications of Race Adjustment in Lung-Function Equations.

The New England journal of medicine

Diao JA, He Y, Khazanchi R, Nguemeni Tiako MJ, Witonsky JI, Pierson E, Rajpurkar P, Elhawary JR, Melas-Kyriazi L, Yen A, Martin AR, Levy S, Patel CJ, Farhat M, Borrell LN, Cho MH, Silverman EK, Burchard EG, Manrai AK

A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma.

Nature communications

Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA

Advancing genomics to improve health equity.

Nature genetics

Madden EB, Hindorff LA, Bonham VL, Akintobi TH, Burchard EG, Baker KE, Begay RL, Carpten JD, Cox NJ, Di Francesco V, Dillard DA, Fletcher FE, Fullerton SM, Garrison NA, Hammack-Aviran CM, Hiratsuka VY, Hildreth JEK, Horowitz CR, Hughes Halbert CA, Inouye M, Jackson A, Landry LG, Kittles RA, Leek JT, Limdi NA, Lockhart NC, Ofili EO, Pérez-Stable EJ, Sabatello M, Saulsberry L, Schools LE, Troyer JL, Wilfond BS, Wojcik GL, Cho JH, Lee SS, Green ED