Eric Verdin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease
Associate Professor
Department of Medicine
[email protected]
+1 415 734-4808
Research Overview: 

Our laboratory focuses on the biology of HIV with a particular emphasis on its transcriptional regulation and the role of chromatin. We are currently focusing on understanding the mechanism of HIV latency, which is mediated by the transcriptional inactivation of the HIV promoter. We also study how HIV proteins modify differentiated functions of immune cells during the infection process.

A second focus of the lab is the role of HDAC7, a histone deacetylase, in lymphocyte development. HDAC7 is highly expressed in double positive (CD4 and CD8) developing T cells.  We found that HDAC7 regulates the expression of a cassette of genes that play a critical role in the process of positive and negative selection. We are currently studying a thymus-specific HDAC7 knockout mouse.

A third focus of the lab is the role of acetylation in mitochondrial functions. We study a protein deacetylase, called SIRT3, and its role in metabolic control and aging.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
HIV Pathogenesis and lymphocyte biology

Websites

Publications: 

Biological and genetic characterization of Physostegia chlorotic mottle virus in Europe based on host range, location, and time.

Plant disease

Temple C, Blouin AG, De Jonghe K, Foucart Y, Botermans M, Westenberg M, Schoen R, Gentit P, Visage M, Verdin E, Wipf-Scheibel C, Ziebell H, Gaafar YZA, Kutnjak D, Vucurovic A, Rivarez MPS, Richert-Pöggeler KR, Ulrich R, Zia A, Yan XH, Massart S

Identification of a novel vitivirus from pineapple in Reunion Island.

Archives of virology

Massé D, Filloux D, Candresse T, Massart S, Marais A, Verdin E, Cassam N, Fernandez E, Roumagnac P, Teycheney PY, Lefeuvre P, Lett JM

The intestinal immune system and gut barrier function in obesity and ageing.

The FEBS journal

Shemtov SJ, Emani R, Bielska O, Covarrubias AJ, Verdin E, Andersen JK, Winer DA

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin.

PLoS pathogens

Lindqvist B, Jütte BB, Love L, Assi W, Roux J, Sönnerborg A, Tezil T, Verdin E, Svensson JP

A proposed unified mitotic chromosome architecture.

Proceedings of the National Academy of Sciences of the United States of America

Sedat J, McDonald A, Kasler H, Verdin E, Cang H, Arigovindan M, Murre C, Elbaum M