Eric Verdin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease
Associate Professor
Department of Medicine
+1 415 734-4808
Research Overview: 

Our laboratory focuses on the biology of HIV with a particular emphasis on its transcriptional regulation and the role of chromatin. We are currently focusing on understanding the mechanism of HIV latency, which is mediated by the transcriptional inactivation of the HIV promoter. We also study how HIV proteins modify differentiated functions of immune cells during the infection process.

A second focus of the lab is the role of HDAC7, a histone deacetylase, in lymphocyte development. HDAC7 is highly expressed in double positive (CD4 and CD8) developing T cells.  We found that HDAC7 regulates the expression of a cassette of genes that play a critical role in the process of positive and negative selection. We are currently studying a thymus-specific HDAC7 knockout mouse.

A third focus of the lab is the role of acetylation in mitochondrial functions. We study a protein deacetylase, called SIRT3, and its role in metabolic control and aging.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
HIV Pathogenesis and lymphocyte biology

Websites

Publications: 

Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.

Journal of virology

Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC

CAGE-seq reveals that HIV-1 latent infection does not trigger unique cellular responses in a Jurkat T cell model.

Journal of virology

Matsui H, Shirakawa K, Konishi Y, Hirabayashi S, Sarca AD, Fukuda H, Nomura R, Stanford E, Horisawa Y, Kazuma Y, Matsumoto T, Yamazaki H, Murakawa Y, Battivelli E, Verdin E, Koyanagi Y, Takaori-Kondo A

ARDD 2020: from aging mechanisms to interventions.

Aging

Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure.

Circulation. Heart failure

Yurista SR, Matsuura TR, Silljé HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD

NAD+ metabolism and its roles in cellular processes during ageing.

Nature reviews. Molecular cell biology

Covarrubias AJ, Perrone R, Grozio A, Verdin E