Eric Verdin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease
Associate Professor
Department of Medicine
+1 415 734-4808
Research Overview: 

Our laboratory focuses on the biology of HIV with a particular emphasis on its transcriptional regulation and the role of chromatin. We are currently focusing on understanding the mechanism of HIV latency, which is mediated by the transcriptional inactivation of the HIV promoter. We also study how HIV proteins modify differentiated functions of immune cells during the infection process.

A second focus of the lab is the role of HDAC7, a histone deacetylase, in lymphocyte development. HDAC7 is highly expressed in double positive (CD4 and CD8) developing T cells.  We found that HDAC7 regulates the expression of a cassette of genes that play a critical role in the process of positive and negative selection. We are currently studying a thymus-specific HDAC7 knockout mouse.

A third focus of the lab is the role of acetylation in mitochondrial functions. We study a protein deacetylase, called SIRT3, and its role in metabolic control and aging.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
HIV Pathogenesis and lymphocyte biology

Websites

Publications: 

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress.

Circulation research

Dikalova AE, Pandey AK, Xiao L, Arslanbaeva L, Sidorova T, Lopez MG, Billings Iv FT, Verdin E, Auwerx J, Harrison DG, Dikalov SI

Chronic inflammation in the etiology of disease across the life span.

Nature medicine

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM

Sixty Years after the First Description: Genome Sequence and Biological Characterization of European Wheat Striate Mosaic Virus Infecting Cereal Crops.

Phytopathology

Sõmera M, Kvarnheden A, Desbiez C, Blystad DR, Sooväli P, Kundu JK, Gantsovski M, Nygren J, Lecoq H, Verdin E, Spetz C, Tamisier L, Truve E, Massart S

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis.

PLoS pathogens

Read DF, Atindaana E, Pyaram K, Yang F, Emery S, Cheong A, Nakama KR, Burnett C, Larragoite ET, Battivelli E, Verdin E, Planelles V, Chang CH, Telesnitsky A, Kidd JM

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.

NPJ aging and mechanisms of disease

Tezil T, Chamoli M, Ng CP, Simon RP, Butler VJ, Jung M, Andersen J, Kao AW, Verdin E