Eric Verdin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease
Associate Professor
Department of Medicine
+1 415 734-4808
Research Overview: 

Our laboratory focuses on the biology of HIV with a particular emphasis on its transcriptional regulation and the role of chromatin. We are currently focusing on understanding the mechanism of HIV latency, which is mediated by the transcriptional inactivation of the HIV promoter. We also study how HIV proteins modify differentiated functions of immune cells during the infection process.

A second focus of the lab is the role of HDAC7, a histone deacetylase, in lymphocyte development. HDAC7 is highly expressed in double positive (CD4 and CD8) developing T cells.  We found that HDAC7 regulates the expression of a cassette of genes that play a critical role in the process of positive and negative selection. We are currently studying a thymus-specific HDAC7 knockout mouse.

A third focus of the lab is the role of acetylation in mitochondrial functions. We study a protein deacetylase, called SIRT3, and its role in metabolic control and aging.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
HIV Pathogenesis and lymphocyte biology

Websites

Publications: 

Biological and genetic characterization of Physostegia chlorotic mottle virus in Europe based on host range, location, and time.

Plant disease

Temple C, Blouin AG, De Jonghe K, Foucart Y, Botermans M, Westenberg M, Schoen R, Gentit P, Visage M, Verdin E, Wipf-Scheibel C, Ziebell H, Gaafar YZA, Kutnjak D, Vucurovic A, Rivarez MPS, Richert-Pöggeler KR, Ulrich R, Zia A, Yan XH, Massart S

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

bioRxiv : the preprint server for biology

Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, Hayashi JM, Cruz A, Shah S, Gross JD, Krogan NJ, Schilling B, Ott M, Verdin E

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.

Nature communications

Meyer B, Chiaravalli J, Gellenoncourt S, Brownridge P, Bryne DP, Daly LA, Grauslys A, Walter M, Agou F, Chakrabarti LA, Craik CS, Eyers CE, Eyers PA, Gambin Y, Jones AR, Sierecki E, Verdin E, Vignuzzi M, Emmott E

SARS-CoV-2, COVID-19 and the Ageing Immune System.

Nature Aging

Bartleson JM, Radenkovic D, Covarrubias AJ, Furman D, Winer DA, Verdin E

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency.

Frontiers in immunology

de Armas LR, Gavegnano C, Pallikkuth S, Rinaldi S, Pan L, Battivelli E, Verdin E, Younis RT, Pahwa R, Williams SL, Schinazi RF, Pahwa S