Emily Goldberg, PhD

Assistant Professsor
Physiology
Research Overview: 

We study how immune dysfunction leads to chronic inflammatory diseases. As inflammation and metabolism are intimately linked, we are interested in dissecting how immune-metabolic interactions regulate the immune system. The major goals of our lab are to understand (1) how changes in systemic metabolism impact immune function, (2) how cellular metabolic pathways regulate immune cell function, and (3) how tissue-resident immune cells regulate inflammation and systemic metabolic health. Ultimately, we are interested in novel biological roles of metabolites and how metabolism inevitably influences diverse cellular processes of leukocytes. We combine expertise in immunology and metabolism to address these outstanding questions, with the goal of developing novel metabolic strategies to alleviate inflammation and improve immune protection. 

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Immunometabolic control of inflammation

Websites

Publications: 

Ketone bodies as chemical signals for the immune system.

American journal of physiology. Cell physiology

Gonzatti MB, Goldberg E

Reversible histone deacetylase activity catalyzes lysine acylation.

bioRxiv : the preprint server for biology

Tsusaka T, Najar MA, Schwarz B, Bohrnsen E, Oses-Prieto JA, Lee C, Burlingame AL, Bosio CM, Burslem GM, Goldberg EL

Non-specific recognition of histone modifications by H3K9bhb antibody.

iScience

Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg EL

Non-specific recognition of histone modifications by H3K9bhb antibody.

bioRxiv : the preprint server for biology

Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg E

Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation.

The Journal of biological chemistry

Goldberg EL, Letian A, Dlugos T, Leveau C, Dixit VD