Emily Goldberg, PhD

Assistant Professsor
Physiology
Research Overview: 

We study how immune dysfunction leads to chronic inflammatory diseases. As inflammation and metabolism are intimately linked, we are interested in dissecting how immune-metabolic interactions regulate the immune system. The major goals of our lab are to understand (1) how changes in systemic metabolism impact immune function, (2) how cellular metabolic pathways regulate immune cell function, and (3) how tissue-resident immune cells regulate inflammation and systemic metabolic health. Ultimately, we are interested in novel biological roles of metabolites and how metabolism inevitably influences diverse cellular processes of leukocytes. We combine expertise in immunology and metabolism to address these outstanding questions, with the goal of developing novel metabolic strategies to alleviate inflammation and improve immune protection. 

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Immunometabolic control of inflammation

Websites

Publications: 

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C

IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2.

Cell metabolism

Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD

Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.

Med (New York, N.Y.)

Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC

How Inflammation Blunts Innate Immunity in Aging.

Interdisciplinary topics in gerontology and geriatrics

Goldberg EL, Shaw AC, Montgomery RR