Deepak Srivastava, MD

Younger Family Director, Gladstone Institute of Cardiovascular Disease
Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology
Professor
Department of Pediatrics
Department of Biochemistry and Biophysics
+1 415 734-2716
Research Description: 

Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Molecular and Genetic Dissection of Cardiogenesis and its role in human disease

Websites

Publications: 

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Circulation research

Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MP, Haldar SM, Lin CY, McKinsey TA

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.

Nature

de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D

Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.

Cell stem cell

Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D

Oligogenic inheritance of a human heart disease involving a genetic modifier.

Science (New York, N.Y.)

Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D

Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.

Frontiers in physiology

Samal E, Evangelista M, Galang G, Srivastava D, Zhao Y, Vedantham V