Recall Faculty
Department of Medicine
Lung Biology Center
Primary Thematic Area
Secondary Thematic Area
Research Summary
Functional roles of diverse fibroblast subsets in pulmonary fibrosis, acute lung injury and bronchopulmonary dysplasia. Cell-based therapeutics for non-malignant lung diseases.
Mentorship Development
12/19/19 ACRA: Setting training expectations for trainees on the academic career track
+1 415 514-4269
Dean Sheppard is a Professor of Medicine. His current research utilizes scRNA sequencing, novel in vivo genetic tools and ex vivo lung organoids to characterize the origin, fate and function of diverse fibroblast subsets and to characterize the roles each population plays in normal homeostasis and in models of pulmonary fibrosis, asthma, acute lung injury and bronchopulmonary dysplasia. Together with Wendell Lim, his lab is also using synthetic biology to generate novel cell-based therapeutics for treatment of non-malignant lung diseases.
Publications
Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome.
Journal of immunology (Baltimore, Md. : 1950)
The avß1 integrin plays a critical in vivo role in tissue fibrosis.
Science translational medicine
TGF-ß activation and function in immunity.
Annual review of immunology
Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Nature medicine
Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing.
The Journal of clinical investigation
IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.
Nature medicine
Expression of avß8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
The Journal of clinical investigation