David Booth, PhD

Assistant Professor

Biochemistry and Biophysics

+1 415 921-9772

Secondary Thematic Area:

None

Research Summary:

With a combination of molecular genetics, biochemistry, functional genomics, and cell biology, we are exploring the molecular mechanisms and environmental cues that govern the transitions between different choanoflagellates cell types.

Publications:

Chromatin profiling identifies putative dual roles for H3K27me3 in regulating transposons and cell type-specific genes in choanoflagellates.

bioRxiv : the preprint server for biology

Gahan JM, Helfrich LW, Wetzel LA, Bhanu NV, Yuan ZF, Garcia BA, Klose R, Booth DS

A red algal polysaccharide influences the multicellular development of the choanoflagellate Salpingoeca rosetta.

bioRxiv : the preprint server for biology

Perotti O, Esparza GV, Booth DS

An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.

Current biology : CB

Coyle MC, Tajima AM, Leon F, Choksi SP, Yang A, Espinoza S, Hughes TR, Reiter JF, Booth DS, King N

Cell polarity in the protist-to-animal transition.

Current topics in developmental biology

Brunet T, Booth DS

The history of Salpingoeca rosetta as a model for reconstructing animal origins.