Daniel Bikle, MD, PhD

Department of Medicine
Department of Dermatology
+1 415 750-2089
Research Overview: 

My research is focused on the hormonal regulation of calcium metabolism, and includes projects involving the classic target tissue of bone as well as non classic tissues such as the skin. The projects  with bone focus on the mechanisms by which parathyroid hormone and insulin like growth factor-1 regulate bone formation and differentiation, the response of bone to mechanical loading and unloading, and the ability of bone to heal fractures. We use a number of cell specific gene deletion models in different cells in the skeleton to address these questions. The projects in skin examine the mechanisms by which calcium and 1,25(OH)2D regulate keratinocyte differentiation, wounding repair, and skin cancer development. We are focusing on the calcium and vitamin D receptors, and the signaling pathways and transcriptional events mediated by their activation and keratinocyte specific deletion.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of cellular differentiation and function by calciotropic hormones



Vitamin D and Long Covid: Is there a role in prevention or treatment?

The Journal of clinical endocrinology and metabolism

Bikle DD

Validation of Biomechanical Computed Tomography for Fracture Risk Classification in Metastatic Hormone-sensitive Prostate Cancer.

European urology oncology

Lin JK, Hearn CM, Getzen E, Long Q, Lee DC, Keaveny TM, Jayadevappa R, Robinson KW, Wong YN, Maxwell KN, Narayan V, Haas NB, Takvorian SU, Bikle DD, Chiang JM, Khan AN, Rajapakse CS, Morgans AK, Parikh RB

Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.

Communications biology

Thaler R, Yoshizaki K, Nguyen T, Fukumoto S, Den Besten P, Bikle DD, Oda Y

Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate.

The Journal of steroid biochemistry and molecular biology

Oda Y, Wong CT, Oh DH, Meyer MB, Pike JW, Bikle DD

Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?

Reviews in endocrine & metabolic disorders

Giustina A, di Filippo L, Allora A, Bikle DD, Cavestro GM, Feldman D, Latella G, Minisola S, Napoli N, Trasciatti S, Uygur M, Bilezikian JP