Daniel Bikle, MD, PhD

Professor
Department of Medicine
Department of Dermatology
+1 415 575-0557
Research Overview: 

My research is focused on the hormonal regulation of calcium metabolism, and includes projects involving the classic target tissue of bone as well as non classic tissues such as the skin. The projects  with bone focus on the mechanisms by which parathyroid hormone and insulin like growth factor-1 regulate bone formation and differentiation, the response of bone to mechanical loading and unloading, and the ability of bone to heal fractures. We use a number of cell specific gene deletion models in different cells in the skeleton to address these questions. The projects in skin examine the mechanisms by which calcium and 1,25(OH)2D regulate keratinocyte differentiation, wounding repair, and skin cancer development. We are focusing on the calcium and vitamin D receptors, and the signaling pathways and transcriptional events mediated by their activation and keratinocyte specific deletion.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of cellular differentiation and function by calciotropic hormones

Websites

Publications: 

Vitamin D metabolism revised: fall of dogmas.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bouillon R, Bikle D

Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.

Journal of the Endocrine Society

Munson S, Wang Y, Chang W, Bikle DD

Skeletal and extra-skeletal actions of vitamin D: Current evidence and outstanding questions.

Endocrine reviews

Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J

New developments in our understanding of vitamin metabolism, action and treatment.

Metabolism: clinical and experimental

Christakos S, Li S, De La Cruz J, Bikle DD