Daniel Bikle, MD, PhD

Professor
Department of Medicine
Department of Dermatology
+1 415 750-2089
Research Overview: 

My research is focused on the hormonal regulation of calcium metabolism, and includes projects involving the classic target tissue of bone as well as non classic tissues such as the skin. The projects  with bone focus on the mechanisms by which parathyroid hormone and insulin like growth factor-1 regulate bone formation and differentiation, the response of bone to mechanical loading and unloading, and the ability of bone to heal fractures. We use a number of cell specific gene deletion models in different cells in the skeleton to address these questions. The projects in skin examine the mechanisms by which calcium and 1,25(OH)2D regulate keratinocyte differentiation, wounding repair, and skin cancer development. We are focusing on the calcium and vitamin D receptors, and the signaling pathways and transcriptional events mediated by their activation and keratinocyte specific deletion.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of cellular differentiation and function by calciotropic hormones

Websites

Publications: 

p120-catenin suppresses proliferation and tumor growth of oral squamous cell carcinoma via inhibiting nuclear phospholipase C-?1 signaling.

Journal of cellular physiology

Li L, Ji S, Shrestha C, Jiang Y, Liao L, Xu F, Liu Z, Bikle DD, Xie Z

Vitamin D metabolism revised: fall of dogmas.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Bouillon R, Bikle D