Carol Gross, PhD

Professor
Department of Cell & Tissue Biology
+1 415 476-1493
Research Overview: 

My overall interest is to study global regulatory networks in the bacterium E. coli, an organism that is amenable to genetic and biochemical approaches. We study two different problems, each of which illuminates this issue from different perspectives. Our study of the heat shock response has led us into a consideration of how the cell monitors and regulates the folding state of proteins, how proteins are targeted for degradation and how the cytoplasmic and periplasmic compartments in E. coli are coordinated. Our study of transcriptional regulatory networks has led us to dissect the functional anatomy of RNA polymerase and to establish a genomics approach to discover the connections between different networks.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Regulation of Gene Expression

Websites

Publications: 

Resistance to serine in Bacillus subtilis: identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism.

Environmental microbiology

Klewing A, Koo BM, Krüger L, Poehlein A, Reuß D, Daniel R, Gross CA, Stülke J

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.

Nature biotechnology

Jost M, Santos DA, Saunders RA, Horlbeck MA, Hawkins JS, Scaria SM, Norman TM, Hussmann JA, Liem CR, Gross CA, Weissman JS

Discovery of the extracytoplasmic function s factors.

Molecular microbiology

Lonetto MA, Donohue TJ, Gross CA, Buttner MJ

Topoisomerase IV can functionally replace all type 1A topoisomerases in Bacillus subtilis.

Nucleic acids research

Reuß DR, Faßhauer P, Mroch PJ, Ul-Haq I, Koo BM, Pöhlein A, Gross CA, Daniel R, Brantl S, Stülke J