Carol Gross, PhD

Professor
Department of Cell & Tissue Biology
+1 415 476-1493
Research Overview: 

My overall interest is to study global regulatory networks in the bacterium E. coli, an organism that is amenable to genetic and biochemical approaches. We study two different problems, each of which illuminates this issue from different perspectives. Our study of the heat shock response has led us into a consideration of how the cell monitors and regulates the folding state of proteins, how proteins are targeted for degradation and how the cytoplasmic and periplasmic compartments in E. coli are coordinated. Our study of transcriptional regulatory networks has led us to dissect the functional anatomy of RNA polymerase and to establish a genomics approach to discover the connections between different networks.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Regulation of Gene Expression

Websites

Publications: 

Expansion and re-classification of the extracytoplasmic function (ECF) s factor family.

Nucleic acids research

Casas-Pastor D, Müller RR, Jaenicke S, Brinkrolf K, Becker A, Buttner MJ, Gross CA, Mascher T, Goesmann A, Fritz G

Rewiring the specificity of extracytoplasmic function sigma factors.

Proceedings of the National Academy of Sciences of the United States of America

Todor H, Osadnik H, Campbell EA, Myers KS, Li H, Donohue TJ, Gross CA

Genetic interaction mapping informs integrative structure determination of protein complexes.

Science (New York, N.Y.)

Braberg H, Echeverria I, Bohn S, Cimermancic P, Shiver A, Alexander R, Xu J, Shales M, Dronamraju R, Jiang S, Dwivedi G, Bogdanoff D, Chaung KK, Hüttenhain R, Wang S, Mavor D, Pellarin R, Schneidman D, Bader JS, Fraser JS, Morris J, Haber JE, Strahl BD, Gross CA, Dai J, Boeke JD, Sali A, Krogan NJ

Bacterial CRISPR screens for gene function.

Current opinion in microbiology

Todor H, Silvis MR, Osadnik H, Gross CA

Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.

Cell systems

Hawkins JS, Silvis MR, Koo BM, Peters JM, Osadnik H, Jost M, Hearne CC, Weissman JS, Todor H, Gross CA