Carol Gross, PhD

Department of Cell & Tissue Biology
+1 415 476-1493
Research Overview: 

My overall interest is to study global regulatory networks in the bacterium E. coli, an organism that is amenable to genetic and biochemical approaches. We study two different problems, each of which illuminates this issue from different perspectives. Our study of the heat shock response has led us into a consideration of how the cell monitors and regulates the folding state of proteins, how proteins are targeted for degradation and how the cytoplasmic and periplasmic compartments in E. coli are coordinated. Our study of transcriptional regulatory networks has led us to dissect the functional anatomy of RNA polymerase and to establish a genomics approach to discover the connections between different networks.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Regulation of Gene Expression



Three bacterial DedA subfamilies with distinct functions and phylogenetic distribution.

bioRxiv : the preprint server for biology

Todor H, Herrera N, Gross C

Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms.


Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS

The context of the ribosome binding site in mRNAs defines specificity of action of kasugamycin, an inhibitor of translation initiation.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Y, Aleksashin NA, Klepacki D, Anderson C, Vázquez-Laslop N, Gross CA, Mankin AS