Carlo Condello, PhD

Assoc Professor
Institute for Neurodegenerative Diseases
+1 415 502-7075
Research Description: 

Neuroscientist with interests in the cell and molecular biology of neurodegenerative diseases, innate immunity, neuron-glial interactions, protein misfolding/prion mechanisms, in vivo/in vitro optical imaging techniques and developing animal models for preclinical studies.

Primary Thematic Area: 
Secondary Thematic Area: 
Research Summary: 
We innovate new imaging methods and model systems to elucidate the cell and molecular biology of neurodegenerative diseases and the role of microglia.
Mentorship Development: 

2/2021 - Three Truths & Three Tries: Facing & Overcoming Critical Social Justice Challenges at the Micro, Mezzo & Macro Levels
5/2021 - Sharpening your Mentoring Skills (SyMS)


Featured Publications: 

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.


Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J

Aß and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.

Science translational medicine

Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB

Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.

Nature structural & molecular biology

Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE

Structural heterogeneity and intersubject variability of Aß in familial and sporadic Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America

Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB