Assoc Professor
Primary Thematic Area
M_IND (Neurodegenerative Dis)
Secondary Thematic Area
Research Summary
We innovate new imaging methods and model systems to elucidate the cell and molecular biology of neurodegenerative diseases and the role of microglia.
Mentorship Development
2/2021 - Three Truths & Three Tries: Facing & Overcoming Critical Social Justice Challenges at the Micro, Mezzo & Macro Levels
5/2021 - Sharpening your Mentoring Skills (SyMS)
7/2021 - Career Conversations
5/2022 - PSPG Faculty Community Circle
10-11/2023 - UCSF Inclusive Mentor/Manager Training
+1 415 502-7075
Neuroscientist with interests in the cell and molecular biology of neurodegenerative diseases, innate immunity, neuron-glial interactions, protein misfolding/prion mechanisms, in vivo/in vitro optical imaging techniques and developing animal models for preclinical studies.
Websites
Publications
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aß42 hotspots around plaques.
Nature communications
Aß and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
Science translational medicine
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
Nature structural & molecular biology
Structural heterogeneity and intersubject variability of Aß in familial and sporadic Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America