Bryan Greenhouse, MD

Associate Professor
Department of Medicine
+1 628 206-8844
Research Description: 

My research group is focused on developing new tools to better measure malaria transmission and determine how some people are able to be infected with malaria parasites without becoming sick. We do this by studying malaria in its natural environment, applying novel laboratory and analytical methods to high quality field studies. Most of our work is based on data and samples collected from field surveillance or clinical trials performed in malaria endemic areas, primarily sub-Saharan Africa. My current projects focus on understanding the development of naturally acquired immunity, creating novel antibody-based tools to measure malaria exposure and immunologic protection, working on improved diagnostics, and using parasite population genetics and spatial data to understand parasite transmission and evolution. My lab is based at Zuckerberg San Francisco General Hospital and Chan Zuckerberg Biohub, where I am an investigator.

Websites

Featured Publications: 

B cell sub-types following acute malaria and associations with clinical immunity.

Malaria journal

Sullivan RT, Ssewanyana I, Wamala S, Nankya F, Jagannathan P, Tappero JW, Mayanja-Kizza H, Muhindo MK, Arinaitwe E, Kamya M, Dorsey G, Feeney ME, Riley EM, Drakeley CJ, Greenhouse B, Sullivan R

Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities.

Proceedings of the National Academy of Sciences of the United States of America

Helb DA, Tetteh KK, Felgner PL, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal PJ, Dorsey G, Drakeley CJ, Greenhouse B

FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.

PLoS pathogens

Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G, Greenhouse B

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait.

Blood

Gong L, Maiteki-Sebuguzi C, Rosenthal PJ, Hubbard AE, Drakeley CJ, Dorsey G, Greenhouse B