Biao Wang, PhD

Asst Professor in Residence
Cardiovascular Research Institute
+1 415 502-2023
Research Overview: 

Adipose tissue regulates systemic energy homeostasis by storing lipids as triglycerides and by secreting adipokines. Dysfunctions of adipose tissue in either obesity (too much fat) or lipoatrophy (too little fat) patients cause metabolic syndromes such as insulin resistance and dyslipidemia. Using orthologous genetic systems (Drosophila and mouse), we are interested in 1) identifying genetic hierarchy of adipocyte lineage development, and 2) investigating molecular mechanisms of adipose tissue remodeling in health and disease states.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Regulatory mechanisms of adipose tissue development and function

Websites

Publications: 

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

The Journal of clinical investigation

Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM

Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity.

The Journal of endocrinology

Paulo E, Wu D, Hecker PA, Zhang Y, Wang B

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.

Scientific reports

Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney DL, Soucheray M, Jimenez-Morales D, Chawla A, Krogan NJ, Wang B

Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.

Cell metabolism

Masand R, Paulo E, Wu D, Wang Y, Swaney DL, Jimenez-Morales D, Krogan NJ, Wang B