Biao Wang, PhD

Assoc Professor in Residence
Cardiovascular Research Institute
+1 415 502-2023
Research Overview: 

Adipose tissue regulates systemic energy homeostasis by storing lipids as triglycerides and by secreting adipokines. Dysfunctions of adipose tissue in either obesity (too much fat) or lipoatrophy (too little fat) patients cause metabolic syndromes such as insulin resistance and dyslipidemia. Using orthologous genetic systems (Drosophila and mouse), we are interested in 1) identifying genetic hierarchy of adipocyte lineage development, and 2) investigating molecular mechanisms of adipose tissue remodeling in health and disease states.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Regulatory mechanisms of adipose tissue development and function



Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.

Cell reports

Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B

Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.

Proceedings of the National Academy of Sciences of the United States of America

Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K

A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.

Proceedings of the National Academy of Sciences of the United States of America

Man K, Bowman C, Braverman KN, Escalante V, Tian Y, Bisanz JE, Ganeshan K, Wang B, Patterson A, Bayrer JR, Turnbaugh PJ, Chawla A

Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.

The Journal of clinical investigation

Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM