Assoc Professor in Residence
Cardiovascular Research Institute
Primary Thematic Area
Secondary Thematic Area
Research Summary
Regulatory mechanisms of adipose tissue development and function
+1 415 502-2023
Adipose tissue regulates systemic energy homeostasis by storing lipids as triglycerides and by secreting adipokines. Dysfunctions of adipose tissue in either obesity (too much fat) or lipoatrophy (too little fat) patients cause metabolic syndromes such as insulin resistance and dyslipidemia. Using orthologous genetic systems (Drosophila and mouse), we are interested in 1) identifying genetic hierarchy of adipocyte lineage development, and 2) investigating molecular mechanisms of adipose tissue remodeling in health and disease states.
Websites
Publications
Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin.
Proceedings of the National Academy of Sciences of the United States of America
Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold.
The Journal of biological chemistry
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
The Journal of clinical investigation
Adipocyte HDAC4 activation leads to beige adipocyte expansion and reduced adiposity.
The Journal of endocrinology
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Scientific reports
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Cell metabolism