Barbara Panning, PhD

Professor

Department of Biochemistry and Biophysics

[email protected]

+1 415 514-0448

Primary Thematic Area:

Developmental & Stem Cell Biology

Secondary Thematic Area:

Cancer Biology & Cell Signaling

Research Summary:

The Panning lab studies mammalian stem cell epigenetics, focusing on X-inactivation and chromatin modifiers.

Publications:

A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.

Science translational medicine

Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.

eLife

Hrit J, Goodrich L, Li C, Wang BA, Nie J, Cui X, Martin EA, Simental E, Fernandez J, Liu MY, Nery JR, Castanon R, Kohli RM, Tretyakova N, He C, Ecker JR, Goll M, Panning B

Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.

Proceedings of the National Academy of Sciences of the United States of America

Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K

Activators and repressors: A balancing act for X-inactivation.

Seminars in cell & developmental biology

Goodrich L, Panning B, Leung KN

SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.