Arthur Weiss, MD, PhD

Ephraim P. Engleman Distinguished Professor
Professor
Department of Medicine
Research Overview: 

The response of lymphocytes to antigen initiates an antigen specific immune response and also represents a unique opportunity to study how complex molecular circuitry within cells andweiss between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with kinase, phosphatase and substrate mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Our lab focuses on the roles of tyrosine kinases and phosphatases in regulating lymphocyte activation, and studies how abnormalities in tyrosine phosphorylation pathways can lead to immunologically-mediated diseases.

Websites

Publications: 

ZAP70, too little, too much can lead to autoimmunity.

Immunological reviews

Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A

Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb.

eLife

Huang F, Nguyen TT, Echeverria I, Ramachandran R, Cary DC, Paculova H, Sali A, Weiss A, Peterlin BM, Fujinaga K

Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway.

Proceedings of the National Academy of Sciences of the United States of America

Lu W, Skrzypczynska KM, Weiss A

Cbl-b deficiency prevents functional but not phenotypic T cell anergy.

The Journal of experimental medicine

Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A