Arnold Kriegstein, MD, PhD

Founding Director
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
Department of Neurology
Research Overview: 

Dr. Kriegstein received BA from Yale University and his MD and PhD degrees from New York University in 1977 where his thesis advisor was Dr. Eric Kandel. He subsequently completed Residency training in Neurology at the Brigham and Women’s Hospital, Children’s Hospital, and Beth Israel Hospital in Boston. He has held academic appointments at Stanford University, Yale University, and Columbia University. In 2004 he joined the Neurology Department at the University of California, San Francisco. He founded the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF and served as Director from 2004-2021. Dr. Kriegstein’s own research focuses on the way in which neural stem and progenitor cells in the embryonic brain produce neurons, and ways in which this information can be used for cell based therapies to treat diseases of the nervous system. His lab found that radial glial cells are neuronal stem cells in the developing brain, and also identified a second type of precursor cell produced by radial glial cells that is responsible for generating specific neuronal subtypes. He has more recently focused on human brain development and described a novel progenitor cell type, the outer radial glial cell, that contributes to the huge expansion of the cerebral cortex. He is using single cell transcriptomics and multi-omics as well as spatial transcriptomics to understand how neuronal diversity is produced during brain development. Organoid models are also employed for functional studies as well as insights into disease mechanisms.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Neurobiology
Research Summary: 
Neural Stem Cells and Embryonic Cortical Development
Mentorship Development: 

4/29/19    Sharpening your Mentoring Skills (SyMS) with Sharon Milgram (Parnassus)    
9/11/20    Mentoring Across Differences
2/16/21    Three Truths and Three Tries: Facing and Overcoming Critical Social Justice Challenges at the Micro, Mezzo, and Macro Levels    

Websites

Publications: 

Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping.

Research square

Zhang D, Rodríguez-Kirby LAR, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen XL, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R

Molecular and cellular dynamics of the developing human neocortex at single-cell resolution.

bioRxiv : the preprint server for biology

Wang L, Wang C, Moriano JA, Chen S, Zuo G, Cebrián-Silla A, Zhang S, Mukhtar T, Wang S, Song M, de Oliveira LG, Bi Q, Augustin JJ, Ge X, Paredes MF, Huang EJ, Alvarez-Buylla A, Duan X, Li J, Kriegstein AR

Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis.

bioRxiv : the preprint server for biology

Ahanger SH, Zhang C, Semenza ER, Gil E, Cole MA, Wang L, Kriegstein AR, Lim DA

Spatial dynamics of mammalian brain development and neuroinflammation by multimodal tri-omics mapping.

bioRxiv : the preprint server for biology

Zhang D, Rubio Rodríguez-Kirby LA, Lin Y, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Wang S, Chen XL, Gao F, Wang D, Xu H, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R

Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.

Cell

Toma K, Zhao M, Zhang S, Wang F, Graham HK, Zou J, Modgil S, Shang WH, Tsai NY, Cai Z, Liu L, Hong G, Kriegstein AR, Hu Y, Körbelin J, Zhang R, Liao YJ, Kim TN, Ye X, Duan X