Aras Mattis, MD, PhD

Associate Professor
Department of Pathology
+1 415 514-3062
Research Overview: 

The Mattis Lab is focused on identifying molecular mechanisms in normal human liver function as well as understanding complex diseases such as non-alcoholic fatty liver disease (NAFLD). In order to develop better models of this disease process we are using human induced pluripotent stem cells that are then differentiated to human hepatocyte like cells (iPSC-derived hepatocytes). Using a combination of these human derived in vitro hepatocyte models and mouse model systems we strive to develop an improved understanding of this disease.

In addition we have small projects to characterize cystic fibrosis liver disease, hepatocellular carcinoma, and cholangiocarcinoma. Located in the UCSF Department of Pathology, we make use of both collaborative efforts and IRB approved access to archived and fresh human tissue.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of hepatic development, metabolism, and paths towards cancer.
Mentorship Development: 

4/12/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Parnassus)
12/12/19    ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
10/20/20    Gathering in Community: a Training for Faculty and Staff



Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas.


Hsu BY, Driscoll J, Human Cholangiocarcinogenesis Project, Tateno C, Mattis AN, Kelley RK, Willenbring H

MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program.

International journal of molecular sciences

Lewis KA, Stroebel BM, Zhang L, Aouizerat B, Mattis AN, Flowers E

AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis.

Scientific reports

Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY

Fluoride-related changes in the fetal cord blood proteome; a pilot study.

Research square

Tuomivaara ST, Goin DE, Fisher SJ, Hall SC, Mattis AN, Den Besten PK

MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program.

Research square

Lewis KA, Stroebel B, Zhang L, Aouizerat B, Mattis A, Flowers E