Aras Mattis, MD, PhD

Assistant Professor
Department of Pathology
+1 415 514-3165
Research Overview: 

The Mattis Lab is focused on identifying molecular mechanisms in normal human liver function as well as understanding complex diseases such as non-alcoholic fatty liver disease (NAFLD). In order to develop better models of this disease process we are using human induced pluripotent stem cells that are then differentiated to human hepatocyte like cells (iPSC-derived hepatocytes). Using a combination of these human derived in vitro hepatocyte models and mouse model systems we strive to develop an improved understanding of this disease.

In addition we have small projects to characterize cystic fibrosis liver disease, hepatocellular carcinoma, and cholangiocarcinoma. Located in the UCSF Department of Pathology, we make use of both collaborative efforts and IRB approved access to archived and fresh human tissue.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of hepatic development, metabolism, and paths towards cancer.
Mentorship Development: 

4/12/19    Acknowleding and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab (Parnassus)
12/12/19    ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
10/20/20    Gathering in Community: a Training for Faculty and Staff

Websites

Publications: 

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation.

Hepatology (Baltimore, Md.)

Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts C, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN

Persistent or recurrent Barrett's neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Bowman CJ, Zhang R, Balitzer D, Wang D, Rabinovitch PS, Kovári BP, Mattis AN, Kakar S, Lauwers GY, Choi WT

iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile.

Gastroenterology

Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ