
Professor
Department of Medicine
+1 415 476-5876
Publications
Structure-activity relationship studies on 2-thienylidene substituted 3-oxo-2,3-dihydrobenzofuran-7-carboxamides as poly (ADP-ribose) polymerase inhibitors.
Bioorganic chemistry
Coordinated protein modules define DNA damage responses to carboplatin at single-cell resolution in human ovarian carcinoma models.
Cell reports. Medicine
Correction: Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England.
Applied health economics and health policy
Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning.
Science advances
Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer.
bioRxiv : the preprint server for biology
Discovery of a Novel [6-6-5-5-6] Pentacyclic Tetrahydrocyclopentaphthalazinone as a Promising PARP Inhibitor Scaffold.
ACS medicinal chemistry letters
Androgen receptor inhibition increases MHC Class I expression and improves immune response in prostate cancer.
Cancer discovery
PARP7 Inhibitors and AHR Agonists Act Synergistically Across a Wide-Range of Cancer Models.
Molecular cancer therapeutics
Synthetic Lethal Targeting of Cyclin Dependent Kinase-12-Deficient Prostate Cancer with PARP Inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Assessing the Value of New Antimicrobials: Evaluations of Cefiderocol and Ceftazidime-Avibactam to Inform Delinked Payments by the NHS in England.
Applied health economics and health policy
Coordinated protein modules define DNA damage responses to carboplatin at single cell resolution in human ovarian carcinoma models.
bioRxiv : the preprint server for biology
Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy.
Cancer discovery
Histone demethylase enzymes KDM5A and KDM5B modulate immune response by suppressing transcription of endogenous retroviral elements.
bioRxiv : the preprint server for biology
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.
bioRxiv : the preprint server for biology
AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid.
bioRxiv : the preprint server for biology
Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning.
bioRxiv : the preprint server for biology
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2-Altered Advanced Solid Tumor Malignancies (NCI 10170).
Cancer research communications
De novo design of drug-binding proteins with predictable binding energy and specificity.
Science (New York, N.Y.)
A Roadmap to Establishing Global Oncology as a Priority Initiative within a National Cancer Institute-Designated Cancer Center.
Journal of the National Cancer Institute
Large tandem duplications in cancer result from transcription and DNA replication collisions.
medRxiv : the preprint server for health sciences
De novo design of drug-binding proteins with predictable binding energy and specificity.
bioRxiv : the preprint server for biology
Cancer Research in 2030: A unique strategic planning process at a comprehensive cancer center.
Preventive oncology & epidemiology
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.
PLoS pathogens
NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.
bioRxiv : the preprint server for biology
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
bioRxiv : the preprint server for biology
Biological insights and novel biomarker discovery through deep learning approaches in breast cancer histopathology.
NPJ breast cancer
Immunotherapeutic targeting and PET imaging of DLL3 in small cell neuroendocrine prostate cancer.
Cancer research
TEAD proteins associate with DNA repair proteins to facilitate cellular recovery from DNA damage.
Molecular & cellular proteomics : MCP
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Proceedings of the National Academy of Sciences of the United States of America
PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors.
Molecular cancer therapeutics
Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2.
Cancer research
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
Cancer research
Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2.
bioRxiv : the preprint server for biology
A whole genome CRISPR screen identifies AHR loss as a mechanism of PARP7 inhibitor resistance.
Molecular cancer therapeutics
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature.
Science advances
Validation of anti-correlated TGFβ signaling and alternative end-joining DNA repair signatures that predict response to genotoxic cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center.
Current epidemiology reports
Hypoxia is a dominant remodeler of the effector T cell surface proteome relative to activation and regulatory T cell suppression.
Molecular & cellular proteomics : MCP
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature.
bioRxiv : the preprint server for biology
A protein interaction landscape of breast cancer.
Science (New York, N.Y.)
Candidaemia incidence in prolonged veno-venous extracorporeal membrane oxygenation.
The Journal of hospital infection
ADP-ribosyltransferases, an update on function and nomenclature.
The FEBS journal
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.
Nature communications
ATR Inhibitors and Paclitaxel in Melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Science advances
Common Susceptibility Loci for Male Breast Cancer.
Journal of the National Cancer Institute
A very long-acting Poly(ADP-ribose) polymerase inhibitor suppresses cancer cell growth in DNA repair-deficient tumor models.
Cancer research
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
bioRxiv : the preprint server for biology
Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA.
Nature communications
Autoantibody landscape in patients with advanced prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24?+?CD29/CD49fhi in mice.
Breast cancer research and treatment
The DNA methylation landscape of advanced prostate cancer.
Nature genetics
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv : the preprint server for biology
Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking.
Nature communications
An integrated molecular profile of endometrioid ovarian cancer.
Gynecologic oncology
Venoarterial extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock - a six-year service evaluation.
Artificial organs
Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy.
Cancer discovery
Correction to: Timing of pubertal stages and breast cancer risk: the Breakthrough Generations Study.
Breast cancer research : BCR
Microbial contamination of heater cooler units used in extracorporeal membrane oxygenation is not aerosolized into the environment: A single-center experience.
Infection control and hospital epidemiology
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Nature communications
Synthetic lethality as an engine for cancer drug target discovery.
Nature reviews. Drug discovery
Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.
PloS one
Klotho: A Major Shareholder in Vascular Aging Enterprises.
International journal of molecular sciences
Strategies for the prevention of peri-operative transoesophageal echocardiography-related complications.
Anaesthesia
DNA-dependent protein kinase drives prostate cancer progression through transcriptional regulation of the Wnt signaling pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research
Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.
Journal of medicinal chemistry
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers.
Nature communications
PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.
The Journal of clinical investigation
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.
Scientific reports
Response to 'Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105?000 UK women in the Generations Study".
British journal of cancer
Response to 'Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105?000 UK women in the Generations Study".
British journal of cancer
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
Nature reviews. Clinical oncology
Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.
Scientific reports
Targeting Tropomyosin Receptor Kinase in Cutaneous CYLD Defective Tumors With Pegcantratinib: The TRAC Randomized Clinical Trial.
JAMA dermatology
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.
Scientific reports
Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
Nature communications
Reply to 'Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105?000 UK women in the Generations Study".
British journal of cancer
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Nature communications
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.
Nature medicine
Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Nature communications
E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Cancer discovery
Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.
International journal of cancer
DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.
The Journal of clinical investigation
Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry.
Cell reports
Domestic light at night and breast cancer risk: a prospective analysis of 105?000 UK women in the Generations Study.
British journal of cancer
The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer.
Health affairs (Project Hope)
Smoking and risk of breast cancer in the Generations Study cohort.
Breast cancer research : BCR
Future cancer research priorities in the USA: a Lancet Oncology Commission.
The Lancet. Oncology
ATR Is a Therapeutic Target in Synovial Sarcoma.
Cancer research
Mapping genetic vulnerabilities reveals BTK as a novel therapeutic target in oesophageal cancer.
Gut
Structural basis for recruitment of BRCA2 by PALB2.
EMBO reports
Modeling Therapy Resistance in BRCA1/2-Mutant Cancers.
Molecular cancer therapeutics
Family history and risk of breast cancer: an analysis accounting for family structure.
Breast cancer research and treatment
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
British journal of cancer
Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors.
Cancer discovery
PARP inhibitors: Synthetic lethality in the clinic.
Science (New York, N.Y.)
Marked for death: targeting epigenetic changes in cancer.
Nature reviews. Drug discovery
Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells.
Scientific data
Childhood body size and pubertal timing in relation to adult mammographic density phenotype.
Breast cancer research : BCR
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.
Nature communications
PARP inhibitor combination therapy.
Critical reviews in oncology/hematology
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Journal of medical genetics
Menopausal hormone therapy and breast cancer: what is the true size of the increased risk?
British journal of cancer
Psychological stress, adverse life events and breast cancer incidence: a cohort investigation in 106,000 women in the United Kingdom.
Breast cancer research : BCR
Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.
Molecular cancer therapeutics
DNA Repair Deficiency Is Common in Advanced Prostate Cancer: New Therapeutic Opportunities.
The oncologist
Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.
The Journal of biological chemistry
Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.
The Journal of pathology
Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Cancer research
BRCAness revisited.
Nature reviews. Cancer
Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
Nature medicine
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.
The New England journal of medicine
Exome Sequencing of an Adult Pituitary Atypical Teratoid Rhabdoid Tumor.
Frontiers in oncology
Inherited cylindromas: lessons from a rare tumour.
The Lancet. Oncology
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.
Journal of the National Cancer Institute
Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis.
Clinical epigenetics
Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer.
Molecular cancer therapeutics
Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Mitochondrial DNA Copy Number in Peripheral Blood Cells and Risk of Developing Breast Cancer.
Cancer research
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Gynecologic oncology
Prediction of breast cancer risk based on profiling with common genetic variants.
Journal of the National Cancer Institute
Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours.
The Journal of pathology
Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.
Cancer discovery
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nature genetics
Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
Molecular cancer therapeutics
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.
Human molecular genetics
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.
American journal of human genetics
The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.
Oncotarget
Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.
Annual review of medicine
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
Nature communications
Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.
Cancer research
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk.
Human molecular genetics
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.
Genome research
Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium.
Human molecular genetics
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.
Human molecular genetics
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.
Breast cancer research : BCR
Reproducibility of estradiol and testosterone levels in postmenopausal women over 5 years: results from the breakthrough generations study.
American journal of epidemiology
An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor.
Cancer discovery
Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.
The Journal of pathology
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.
American journal of human genetics
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.
Human molecular genetics
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.
Cancer research
Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
Endocrine-related cancer
The genomic landscape of oesophagogastric junctional adenocarcinoma.
The Journal of pathology
Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study.
Clinical cancer research : an official journal of the American Association for Cancer Research
Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase.
Molecular cancer therapeutics
BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.
Cancer discovery
Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency.
Genetics in medicine : official journal of the American College of Medical Genetics
Changes in estradiol and testosterone levels in postmenopausal women after changes in body mass index.
The Journal of clinical endocrinology and metabolism
Noninvasive detection of HER2 amplification with plasma DNA digital PCR.
Clinical cancer research : an official journal of the American Association for Cancer Research
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Nature genetics
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
Nature genetics
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.
American journal of human genetics
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor.
The Journal of pathology
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family.
Nature reviews. Drug discovery
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
Nature genetics
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells.
EMBO molecular medicine
Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib.
Breast cancer research and treatment
9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
AXL and acquired resistance to EGFR inhibitors.
Nature genetics
Genomic characterisation of acral melanoma cell lines.
Pigment cell & melanoma research
Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.
Stem cells (Dayton, Ohio)
Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.
Nucleic acids research
Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor.
Breast cancer research and treatment
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Cancer discovery
Body mass index, exercise, and other lifestyle factors in relation to age at natural menopause: analyses from the breakthrough generations study.
American journal of epidemiology
CYP3A variation, premenopausal estrone levels, and breast cancer risk.
Journal of the National Cancer Institute
Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk.
Cancer research
A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.
The Journal of pathology
The potential of exploiting DNA-repair defects for optimizing lung cancer treatment.
Nature reviews. Clinical oncology
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
The EMBO journal
Genome-wide association analysis identifies three new breast cancer susceptibility loci.
Nature genetics
Familial concordance for height and its components: analyses from the Breakthrough Generations Study.
American journal of human biology : the official journal of the Human Biology Council
Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines.
BMC medical genomics
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing.
Genome biology
Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men.
PLoS genetics
Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma.
Science translational medicine
Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor.
Genes, chromosomes & cancer
Challenges translating breast cancer gene signatures into the clinic.
Nature reviews. Clinical oncology
Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.
Human molecular genetics
Functional viability profiles of breast cancer.
Cancer discovery
Therapeutic potential of PARP inhibitors for metastatic breast cancer.
Expert review of anticancer therapy
Functional characterization of EMSY gene amplification in human cancers.
The Journal of pathology
FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression.
The Journal of pathology
Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology.
Breast cancer research and treatment
Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.
Cell cycle (Georgetown, Tex.)
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen.
Proceedings of the National Academy of Sciences of the United States of America
Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer.
Nature reviews. Clinical oncology
Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement.
Journal of the National Cancer Institute
Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Biomarkers of PARP inhibitor sensitivity.
Breast cancer research and treatment
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
Journal of the National Cancer Institute
Searching for synthetic lethality in cancer.
Current opinion in genetics & development
Emerging therapeutic targets in endometrial cancer.
Nature reviews. Clinical oncology
Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type.
The Journal of pathology
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
Nature genetics
Synthetic lethal approaches to breast cancer therapy.
Nature reviews. Clinical oncology
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Science translational medicine
Therapeutic targeting of the DNA mismatch repair pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
Cell stem cell
Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Making the best of PARP inhibitors in ovarian cancer.
Nature reviews. Clinical oncology
Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.
PLoS genetics
A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Does the prophylactic administration of N-acetylcysteine prevent acute kidney injury following cardiac surgery?
Interactive cardiovascular and thoracic surgery
PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Using functional genetics to understand breast cancer biology.
Cold Spring Harbor perspectives in biology
DNA amplifications in breast cancer: genotypic-phenotypic correlations.
Future oncology (London, England)
Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.
Gastroenterology
Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
EMBO molecular medicine
Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas.
The Journal of pathology
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
Cancer research
Mismatch repair deficient colorectal cancer in the era of personalized treatment.
Nature reviews. Clinical oncology
Breast cancer molecular profiling with single sample predictors: a retrospective analysis.
The Lancet. Oncology
Genomic instability and the selection of treatments for cancer.
The Journal of pathology
Familial breast cancer: the first linkage.
The Lancet. Oncology
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.
The Journal of pathology
IRF4 polymorphism rs872071 and risk of Hodgkin lymphoma.
British journal of haematology
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis.
The Journal of pathology
Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation.
The Journal of pathology
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.
EMBO molecular medicine
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
EMBO molecular medicine
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers.
Breast cancer research and treatment
Structural basis for recruitment of BRCA2 by PALB2.
EMBO reports
Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components.
The Journal of pathology
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
The New England journal of medicine
Bringing DNA repair in tumors into focus.
Clinical cancer research : an official journal of the American Association for Cancer Research
Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells.
Breast cancer research : BCR
Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?
Genes, chromosomes & cancer
Tiling path genomic profiling of grade 3 invasive ductal breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research
PPM1D is a potential therapeutic target in ovarian clear cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines.
Breast cancer research and treatment
Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization.
The Biochemical journal
Drug resistance caused by reversion mutation.
Cancer research
Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Can genetic testing guide treatment in breast cancer?
European journal of cancer (Oxford, England : 1990)
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.
DNA repair
Targeted therapy for cancer using PARP inhibitors.
Current opinion in pharmacology
ESR1 gene amplification in breast cancer: a common phenomenon?
Nature genetics
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Dissecting resistance to endocrine therapy in breast cancer.
Cell cycle (Georgetown, Tex.)
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
The EMBO journal
BRCA1 and stem cells: tumour typecasting.
Nature cell biology
Lkb1 deficiency causes prostate neoplasia in the mouse.
Cancer research
DNA repair deficiency as a therapeutic target in cancer.
Current opinion in genetics & development
Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.
Laboratory investigation; a journal of technical methods and pathology
Association of genetic variants at 8q24 with breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.
Molecular cell
Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy.
Human molecular genetics
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
Cancer cell
Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007.
Gynecologic oncology
Pregnancy and the risk of breast cancer.
Endocrine-related cancer
Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.
The Journal of investigative dermatology
Neuregulin3 alters cell fate in the epidermis and mammary gland.
BMC developmental biology
Mechanisms of disease: angiogenesis and the management of breast cancer.
Nature clinical practice. Oncology
Utilizing RNA interference to enhance cancer drug discovery.
Nature reviews. Drug discovery
Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.
Genes, chromosomes & cancer
Effect of delays in processing blood samples on measured endogenous plasma sex hormone levels in women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
RAD51, BRCA2 and DNA repair: a partial resolution.
Nature structural & molecular biology
Analysis of PALB2/FANCN-associated breast cancer families.
Proceedings of the National Academy of Sciences of the United States of America
Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Human molecular genetics
Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research
Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.
Laboratory investigation; a journal of technical methods and pathology
Molecular response to aromatase inhibitor treatment in primary breast cancer.
Breast cancer research : BCR
Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.
Breast cancer research : BCR
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
The Journal of cell biology
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
Cancer research
Targeting the double-strand DNA break repair pathway as a therapeutic strategy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk.
Journal of the National Cancer Institute
The effect of the stromal component of breast tumours on prediction of clinical outcome using gene expression microarray analysis.
Breast cancer research : BCR
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes, chromosomes & cancer
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Laboratory investigation; a journal of technical methods and pathology
10th Biennial Helene Harris Memorial Trust meeting.
Cancer research
Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells.
Journal of clinical pathology
Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (cytoxan) (AC) response and resistance.
Breast cancer research and treatment
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Molecular cancer therapeutics
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
EMBO reports
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.
Breast cancer research : BCR
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells.
Breast cancer research : BCR
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
American journal of physiology. Endocrinology and metabolism
Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study.
Lancet (London, England)
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
Cancer biology & therapy
Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
Genes & development
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity.
The Journal of pathology
Targeting the DNA repair defect of BRCA tumours.
Current opinion in pharmacology
BRCA1 and BRCA2 as ovarian cancer susceptibility genes.
Carcinogenesis
Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells.
BMC cancer
Hallmarks of 'BRCAness' in sporadic cancers.
Nature reviews. Cancer
BRCA2 in meiosis: turning over a new leaf.
Trends in cell biology
Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.
Biochimica et biophysica acta
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
Human molecular genetics
Stem cells and breast cancer: A field in transit.
Nature reviews. Cancer
Close relatives or distant cousins?
The Lancet. Oncology
Phenotypic effects of heterozygosity for a BRCA2 mutation.
Human molecular genetics
Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1.
Human molecular genetics
New biology of the oestrogen receptor.
Lancet (London, England)
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
Oncogene
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.
EMBO reports
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
The EMBO journal
X-chromosome inactivation: X marks the spot for BRCA1.
Current biology : CB
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.
Trends in molecular medicine
Functional and molecular characterisation of mammary side population cells.
Breast cancer research : BCR
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line.
BMC molecular biology
MAP kinase phosphatases.
Genome biology
Biomedicine. D-Day for BRCA2.
Science (New York, N.Y.)