Adam Ferguson, PhD

Associate Professor
Department of Neurological Surgery
Brain and Spinal Injury Center (BASIC)
+1 628 206-3734
Research Overview: 

Background: Our research focuses on mechanisms of recovery after neurological trauma. Injuries to the brain and spinal cord invoke numerous, interacting biological processes that work in concert to determine recovery success. Some of these biological processes have contradictory effects at different phases of recovery. For example, mechanisms of synaptic regulation can contribute to cell death in the early phases of recovery but may promote plasticity and restoration of function at later stages.  Understanding the mechanisms of recovery in the complex microenvironment of the injured central nervous system (CNS) requires large-scale integration of biological information and functional outcomes (i.e., Bioinformatics). Our work uses a combination of laboratory studies and statistical modeling approaches to provide an information-rich picture of the syndrome produced by trauma in translational in vivo models.  The long term goal of this research is to provide system-level therapeutic targets for enhancing recovery of function after brain and spinal injury.

Overarching goal: Understand and harness CNS plasticity to promote recovery of function after brain and spinal cord injury through bench-science and translational computational approaches.
 

Ongoing Research:

Computational Syndromic Discovery: Development of aggregate databases of basic spinal cord injury and traumatic brain injury research data from multiple research centers to enable sophisticated knowledge-discovery, data-sharing, and multivariate quantification of the complete constellation of changes produced by neurotrauma.

Bench science: Inflammatory modulation of glutamate-receptor metaplasticity and its role in spinal cord learning and recovery of function after neurotrauma. Techniques: biochemistry (quantitative western, qRT-PCR, ELISA), histology (immunohistochemistry, in situ hybridization), quantitative image analysis (robotic microscopy, confocal, deconvolution, image math) and behavioral analysis (locomotor scaling, fine-motor control, learning and memory).

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
CNS Plasticity, Bioinformatics, and Recovery from Injury

Websites

Publications: 

Preclinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases.

Journal of neurotrauma

LaPlaca MC, Huie JR, Alam HB, Bachstetter AD, Bayir H, Bellgowan PSF, Cummings D, Dixon CE, Ferguson AR, Ferland-Beckham C, Floyd C, Friess S, Galanopoulou A, Hall ED, Harris NG, Hawkins BE, Hicks R, Hulbert LE, Johnson VE, Kabitzke P, Lafrenaye AD, Lemmon V, Lifshitz C, Lifshitz J, Loane DJ, Misquitta L, Nikolian VC, Noble L, Smith DH, Taylor-Burds C, Umoh N, Vovk O, Williams AM, Young M, Zai L

Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Cohen-Adad J, Dhall SS, Talbott JF

Analysis of Normal High-Frequency Intracranial Pressure Values and Treatment Threshold in Neurocritical Care Patients: Insights into Normal Values and a Potential Treatment Threshold.

JAMA neurology

Hawryluk GWJ, Nielson JL, Huie JR, Zimmermann L, Saigal R, Ding Q, Hirschi R, Zeiler FA, Ferguson A, Manley G

The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study.

Science advances

Palacios EM, Owen JP, Yuh EL, Wang MB, Vassar MJ, Ferguson AR, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Robertson CS, Stein MB, Temkin N, Jain S, McCrea M, MacDonald CL, Levin HS, Manley GT, Mukherjee P

Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: A chronic issue.

Experimental neurology

Irvine KA, Sahbaie P, Ferguson AR, Clark JD