Adam Ferguson, MS, PhD

Professor
Department of Neurological Surgery
Brain and Spinal Injury Center (BASIC)
+1 415 476-5326
Research Overview: 

Background: Our research focuses on mechanisms of recovery after neurological trauma. Injuries to the brain and spinal cord invoke numerous, interacting biological processes that work in concert to determine recovery success. Some of these biological processes have contradictory effects at different phases of recovery. For example, mechanisms of synaptic regulation can contribute to cell death in the early phases of recovery but may promote plasticity and restoration of function at later stages.  Understanding the mechanisms of recovery in the complex microenvironment of the injured central nervous system (CNS) requires large-scale integration of biological information and functional outcomes (i.e., Bioinformatics). Our work uses a combination of laboratory studies and statistical modeling approaches to provide an information-rich picture of the syndrome produced by trauma in translational in vivo models.  The long term goal of this research is to provide system-level therapeutic targets for enhancing recovery of function after brain and spinal injury.

Overarching goal: Understand and harness CNS plasticity to promote recovery of function after brain and spinal cord injury through bench-science and translational computational approaches.
 

Ongoing Research:

Computational Syndromic Discovery: Development of aggregate databases of basic spinal cord injury and traumatic brain injury research data from multiple research centers to enable sophisticated knowledge-discovery, data-sharing, and multivariate quantification of the complete constellation of changes produced by neurotrauma.

Bench science: Inflammatory modulation of glutamate-receptor metaplasticity and its role in spinal cord learning and recovery of function after neurotrauma. Techniques: biochemistry (quantitative western, qRT-PCR, ELISA), histology (immunohistochemistry, in situ hybridization), quantitative image analysis (robotic microscopy, confocal, deconvolution, image math) and behavioral analysis (locomotor scaling, fine-motor control, learning and memory).

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Immunology
Research Summary: 
CNS Plasticity, Bioinformatics, and Recovery from Injury
Mentorship Development: 

5/2024 - How to Transparently Set (Perform and Conduct) Expectations

Websites

Publications: 

A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative.

The Lancet. Neurology

Manley GT, Dams-O'Connor K, Alosco ML, Awwad HO, Bazarian JJ, Bragge P, Corrigan JD, Doperalski A, Ferguson AR, Mac Donald CL, Menon DK, McNett MM, van der Naalt J, Nelson LD, Pisica D, Silverberg ND, Umoh N, Wilson L, Yuh EL, Zetterberg H, Maas AIR, McCrea MA, NIH-NINDS TBI Classification and Nomenclature Initiative

Clinical Assessment on Days 1-14 for the Characterization of Traumatic Brain Injury: Recommendations from the 2024 NINDS Traumatic Brain Injury Classification and Nomenclature Initiative Clinical/Symptoms Working Group.

Journal of neurotrauma

Menon DK, Silverberg ND, Ferguson AR, Bayuk TJ, Bhattacharyay S, Brody DL, Cota SA, Ercole A, Figaji A, Gao G, Giza CC, Lecky F, Mannix R, Mikolic A, Moritz KE, Robertson CS, Torres-Espin A, Tsetsou S, Yue JK, Awad HO, Dams-O'Connor K, Doperalski A, Maas AIR, McCrea MA, Umoh N, Manley GT

194 Privacy-Preserving Federated Learning (FL) Across the Modern International Data Sets of TRACK-TBI and CENTER-TBI: Developing the IMPACT-FL Prognostic Model.

Neurosurgery

Patrick Belton, Abel Torres-Espin, Justin Wong, HE Hinson, Thomas Kuipers, Bart Hoekstra, Sonia Jain, Xiaoying Sun, John K. Yue, Dana Pisica, Ana Mikolic, Amy Markowitz, Adam Ferguson, David K. Menon, Andrew Ian Ramsay Maas, Ewout W. Steyerberg, Geoffrey T. Manley, Jonathan Blalock

Disuse plasticity limits spinal cord injury recovery.

iScience

Morioka K, Tazoe T, Huie JR, Hayakawa K, Okazaki R, Guandique CF, Almeida CA, Haefeli J, Hamanoue M, Endoh T, Tanaka S, Bresnahan JC, Beattie MS, Ogata T, Ferguson AR

Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury.

Brain sciences

Juan Sebastián Jara, Marwa A. Soliman, Amanda Bernstein, Paola di Grazia, Adam R. Ferguson, Justin M. Brown, Abel Torres-Espín, Edmund R. Hollis