Adam Ferguson, PhD

Associate Professor
Department of Neurological Surgery
Brain and Spinal Injury Center (BASIC)
+1 628 206-3734
Research Overview: 

Background: Our research focuses on mechanisms of recovery after neurological trauma. Injuries to the brain and spinal cord invoke numerous, interacting biological processes that work in concert to determine recovery success. Some of these biological processes have contradictory effects at different phases of recovery. For example, mechanisms of synaptic regulation can contribute to cell death in the early phases of recovery but may promote plasticity and restoration of function at later stages.  Understanding the mechanisms of recovery in the complex microenvironment of the injured central nervous system (CNS) requires large-scale integration of biological information and functional outcomes (i.e., Bioinformatics). Our work uses a combination of laboratory studies and statistical modeling approaches to provide an information-rich picture of the syndrome produced by trauma in translational in vivo models.  The long term goal of this research is to provide system-level therapeutic targets for enhancing recovery of function after brain and spinal injury.

Overarching goal: Understand and harness CNS plasticity to promote recovery of function after brain and spinal cord injury through bench-science and translational computational approaches.
 

Ongoing Research:

Computational Syndromic Discovery: Development of aggregate databases of basic spinal cord injury and traumatic brain injury research data from multiple research centers to enable sophisticated knowledge-discovery, data-sharing, and multivariate quantification of the complete constellation of changes produced by neurotrauma.

Bench science: Inflammatory modulation of glutamate-receptor metaplasticity and its role in spinal cord learning and recovery of function after neurotrauma. Techniques: biochemistry (quantitative western, qRT-PCR, ELISA), histology (immunohistochemistry, in situ hybridization), quantitative image analysis (robotic microscopy, confocal, deconvolution, image math) and behavioral analysis (locomotor scaling, fine-motor control, learning and memory).

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
CNS Plasticity, Bioinformatics, and Recovery from Injury

Websites

Publications: 

Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury.

Spinal cord

Ehsanian R, Haefeli J, Quach N, Kosarchuk J, Torres D, Stuck ED, Endo J, Crew JD, Dirlikov B, Bresnahan JC, Beattie MS, Ferguson AR, McKenna SL

FAIR SCI Ahead: the evolution of the Open Data Commons for preclinical spinal cord injury research (ODC-SCI.org).

Journal of neurotrauma

Fouad K, Bixby JL, Callahan A, Grethe JS, Jakeman LB, Lemmon VP, Magnuson DS, Martone ME, Nielson JL, Schwab J, Taylor-Burds C, Tetzlaff W, Torres-Espín A, Ferguson AR

Clinical implementation of a novel spinal cord perfusion pressure protocol in acute traumatic spinal cord injury at a U.S. Level I trauma center: A TRACK-SCI study.

World neurosurgery

Yue JK, Hemmerle DP, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS

Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study.

The Lancet. Neurology

Yue JK, Yuh EL, Korley FK, Winkler EA, Sun X, Puffer RC, Deng H, Choy W, Chandra A, Taylor SR, Ferguson AR, Huie JR, Rabinowitz M, Puccio AM, Mukherjee P, Vassar MJ, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Jain S, Manley GT

Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma.

Scientific reports

Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS