Michael Rosenblum, MD, PhD

Assistant Professor
Department of Dermatology
Research Overview: 

The central focus of my lab is to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. To this end, we currently have two areas of active investigation:

  1. Understanding how regulatory T cells (Tregs) control immune responses in tissues
  2. Understanding the ‘alternative’ functions of Tregs in tissues

Approach
Because of its complex immunological properties, its accessibility, and potential for clinical translation, the skin is the model peripheral tissue that we currently study. Approximately 50% of our research employs a reductionist approach, utilizing transgenic animal models to ask fundamental questions of how the immune system functions in skin at both the cellular and molecular levels. The other half of our work focuses on doing functional immunology with human skin, human blood and humanized mice.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
None
Research Summary: 
Defining the cellular and molecular mechanisms of immune regulation in peripheral tissues

Websites

Publications: 

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo.

Journal of visualized experiments : JoVE

Moss MI, Pauli M, Moreau JM, Cohen JN, Rosenblum MD, Lowe MM

Transforming growth factor-ß1 in regulatory T cell biology.

Science immunology

Moreau JM, Velegraki M, Bolyard C, Rosenblum MD, Li Z

MTHFD2, metabolic mastermind of CD4+ T cell destiny.

Science immunology

Gouirand V, Rosenblum MD

Identifying and antagonizing the interactions between layilin and glycosylated collagens.

Cell chemical biology

Glasgow JE, Byrnes JR, Barbee SD, Moreau JM, Rosenblum MD, Wells JA

Author Correction: Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin.

Scientific reports

Ahn RS, Taravati K, Lai K, Lee KM, Nititham J, Gupta R, Chang DS, Arron ST, Rosenblum M, Liao W