
Professor
Department of Medicine
Primary Thematic Area
Secondary Thematic Area
Publications
Phase II (Alliance A091802) Randomized Trial of Avelumab Plus Cetuximab Versus Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Characterizing safety, toxicity, and breast cancer risk reduction using a long-term fulvestrant eluting implant.
Scientific reports
Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors.
Breast cancer research : BCR
A first-in-human phase 1/2 dose-escalation study of MAK683 (EED inhibitor) in patients with advanced malignancies.
European journal of cancer (Oxford, England : 1990)
Estrogens and breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology
Updated Survival Follow-Up for Phase Ib Trial of the Histone Deacetylase Inhibitor Abexinostat With Pazopanib in Patients With Solid Tumor Malignancies.
JCO precision oncology
ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Nab-Paclitaxel in Patients with Advanced Solid Tumors.
Cancer research communications
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2-Altered Advanced Solid Tumor Malignancies (NCI 10170).
Cancer research communications
Synthetic Lethality Beyond BRCA: A Phase I Study of Rucaparib and Irinotecan in Metastatic Solid Tumors With Homologous Recombination-Deficiency Mutations Beyond BRCA1/2.
JCO precision oncology
First-in-Human Phase I Trial of TPST-1120, an inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors.
Cancer research communications
Correction: Combination of Itacitinib or Parsaclisib with Pembrolizumab in Patients with Advanced Solid Tumors: A Phase I Study.
Cancer research communications
Phase 1 study of Elraglusib (9-ING-41), a glycogen synthase kinase-3b inhibitor, as monotherapy or combined with chemotherapy in patients with advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Combination of Itacitinib or Parsaclisib with Pembrolizumab in Patients with Advanced Solid Tumors: A Phase I Study.
Cancer research communications
A Phase 1b/2 Study of Alpelisib in Combination with Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
Targeted oncology
A long-term fulvestrant eluting implant is safe, non-toxic, and reduces the risk of breast cancer in in vivo models.
Research square
Vaccinia (Smallpox) for the Treatment of Ovarian Cancer-Turning an Old Foe Into a Friend?
JAMA oncology
Pembrolizumab alone and pembrolizumab plus chemotherapy in previously treated, extrapulmonary poorly differentiated neuroendocrine carcinomas.
British journal of cancer
ATM-SPARK: A GFP phase separation-based activity reporter of ATM.
Science advances
Targeting RAD51-Mediated Homologous Recombination as a Treatment for Advanced Solid and Hematologic Malignancies: Opportunities and Challenges Ahead.
OncoTargets and therapy
Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Antagonist, with Nab-Paclitaxel in Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Phase II Study of Enzalutamide for Patients With Androgen Receptor-Positive Salivary Gland Cancers (Alliance A091404).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
A Phase IB Trial of the PI3K Inhibitor Alpelisib and Weekly Cisplatin in Patients with Solid Tumor Malignancies.
Cancer research communications
Late-onset Proteus syndrome with cerebriform connective tissue nevus and subsequent development of intraductal papilloma.
American journal of medical genetics. Part A
Malignant glioma subset from actuate 1801: Phase I/II study of 9-ING-41, GSK-3β inhibitor, monotherapy or combined with chemotherapy for refractory malignancies.
Neuro-oncology advances
Glucocorticoid Receptor Antagonism Upregulates Somatostatin Receptor Subtype 2 Expression in ACTH-Producing Neuroendocrine Tumors: New Insight Based on the Selective Glucocorticoid Receptor Modulator Relacorilant.
Frontiers in endocrinology
Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial.
The Lancet. Oncology
A Phase 1 Dose-Escalation and Expansion Study of Telaglenastat in Patients With Advanced or Metastatic Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis.
Blood cancer discovery
Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors.
Magnetic resonance in medicine
Immunotherapy in breast cancer: A clinician's perspective.
Journal of the National Cancer Center
Transcriptional analysis of metastatic uveal melanoma survival nominates NRP1 as a therapeutic target.
Melanoma research
Phase I study of liposomal irinotecan in patients with metastatic breast cancer: findings from the expansion phase.
Breast cancer research and treatment
Commentary: GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.
Frontiers in immunology
Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors.
Journal for immunotherapy of cancer
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors.
The New England journal of medicine
Exhausted T cell signature predicts immunotherapy response in ER-positive breast cancer.
Nature communications
Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Nature communications
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
Nature communications
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy.
Cancer management and research
Before Consent: Qualitative Analysis of Deliberations of Patients With Advanced Cancer About Early-Phase Clinical Trials.
Journal of oncology practice
Reply: Strategies to Prevent Cardiotoxicity.
Journal of the American College of Cardiology
Randomized phase II trial and tumor mutational spectrum analysis from cabozantinib versus chemotherapy in metastatic uveal melanoma (Alliance A091201).
Clinical cancer research : an official journal of the American Association for Cancer Research
Maintenance Lenalidomide in Primary CNS Lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology
Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer.
Journal of the American College of Cardiology
Histone deacetylase inhibition with panobinostat combined with intensive induction chemotherapy in older patients with acute myeloid leukemia: Phase I study results.
Clinical cancer research : an official journal of the American Association for Cancer Research
A dual pathway inhibition strategy using BKM120 combined with vemurafenib is poorly tolerated in BRAF V600E/K mutant advanced melanoma.
Pigment cell & melanoma research
Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies.
Journal of magnetic resonance (San Diego, Calif. : 1997)
Safety and pharmacokinetics of MM-302, a HER2-targeted antibody-liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study.
British journal of cancer
Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma.
Blood advances
A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors.
Annals of oncology : official journal of the European Society for Medical Oncology
Phase I Study of CC-486 Alone and in Combination With Carboplatin or nab-paclitaxel in Patients With Relapsed or Refractory Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gonadotropin-Releasing Hormone Agonists During Chemotherapy for Preservation of Ovarian Function and Fertility in Premenopausal Patients With Early Breast Cancer: A Systematic Review and Meta-Analysis of Individual Patient-Level Data.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer.
Magnetic resonance in medicine
Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer.
Scientific reports
Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors.
Breast cancer research : BCR
Autologous Fat Grafting as a Novel Antiestrogen Vehicle for the Treatment of Breast Cancer.
Plastic and reconstructive surgery
Differential Toxicity in Patients with and without DNA Repair Mutations: Phase I Study of Carboplatin and Talazoparib in Advanced Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
What advanced cancer patients with limited treatment options know about clinical research: a qualitative study.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal.
Annals of oncology : official journal of the European Society for Medical Oncology
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.
Cancer immunology research
Lisinopril or Coreg CR in reducing cardiotoxicity in women with breast cancer receiving trastuzumab: A rationale and design of a randomized clinical trial.
American heart journal
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay.
Cancer management and research
Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Randomized phase 1 crossover study assessing the bioequivalence of capsule and tablet formulations of dovitinib (TKI258) in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology
Effect of Temporary Ovarian Suppression on Chemotherapy-Induced Amenorrhea, Pregnancy, and Outcome.
JAMA oncology
Interest in initiating an early phase clinical trial: results of a longitudinal study of advanced cancer patients.
Psycho-oncology
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma.
Annals of oncology : official journal of the European Society for Medical Oncology
A phase 1b study of the Akt-inhibitor MK-2206 in combination with weekly paclitaxel and trastuzumab in patients with advanced HER2-amplified solid tumor malignancies.
Breast cancer research and treatment
Can ovarian suppression with gonadotropin-releasing hormone analogs (GnRHa) preserve fertility in cancer patients?
Annals of oncology : official journal of the European Society for Medical Oncology
First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Association of tamoxifen use and ovarian function in patients with invasive or pre-invasive breast cancer.
Breast cancer research and treatment
Results of a phase 1 trial combining ridaforolimus and MK-0752 in patients with advanced solid tumours.
European journal of cancer (Oxford, England : 1990)
A Phase I Trial of Combined Ridaforolimus and MK-2206 in Patients with Advanced Malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research
More Options for Fertility Preservation for Patients With Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Ovarian protection during adjuvant chemotherapy.
The New England journal of medicine
Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen-resistant breast cancer models, by reversing Bcl-2 overexpression.
Breast cancer research : BCR
Phase I dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Epigenetic modulation with histone deacetylase inhibitors in combination with immunotherapy.
Epigenomics
Impact of patient ethnicity on the metabolic and immunologic effects of PI3K-mTOR pathway inhibition in patients with solid tumor malignancies.
Cancer chemotherapy and pharmacology
New protein kinase inhibitors in breast cancer: afatinib and neratinib.
Expert opinion on pharmacotherapy
Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Phase 1b study of safety, tolerability and efficacy of R1507, a monoclonal antibody to IGF-1R in combination with multiple standard oncology regimens in patients with advanced solid malignancies.
Cancer chemotherapy and pharmacology
Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
A phase I, randomized, open-label study of the multiple-dose pharmacokinetics of vemurafenib in patients with BRAF V600E mutation-positive metastatic melanoma.
Cancer chemotherapy and pharmacology
Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.
Science translational medicine
Histone deacetylase regulation of ATM-mediated DNA damage signaling.
Molecular cancer therapeutics
Fertility preservation and breast cancer: A complex problem.
Oncology (Williston Park, N.Y.)
Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromata
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Temsirolimus combined with sorafenib in hepatocellular carcinoma: a phase I dose-finding trial with pharmacokinetic and biomarker correlates.
Annals of oncology : official journal of the European Society for Medical Oncology
Developing safety criteria for introducing new agents into neoadjuvant trials.
Clinical cancer research : an official journal of the American Association for Cancer Research
The impact of an electronic health questionnaire on symptom management and behavior reporting for breast cancer survivors.
Breast cancer research and treatment
A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab.
Breast cancer research and treatment
Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Phase I clinical trial of the Src inhibitor dasatinib with dacarbazine in metastatic melanoma.
British journal of cancer
Preclinical and clinical activity of the topoisomerase I inhibitor, karenitecin, in melanoma.
Expert opinion on investigational drugs
Epigenetic modulation: a novel therapeutic target for overcoming hormonal therapy resistance.
Epigenomics
Phase II study of single-agent bosutinib, a Src/Abl tyrosine kinase inhibitor, in patients with locally advanced or metastatic breast cancer pretreated with chemotherapy.
Annals of oncology : official journal of the European Society for Medical Oncology
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer.
British journal of cancer
Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies.
American journal of medical genetics. Part C, Seminars in medical genetics
Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer.
Future oncology (London, England)
A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker.
British journal of cancer
Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
HDAC2 regulates chromatin plasticity and enhances DNA vulnerability.
Molecular cancer therapeutics
A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC.
Clinical cancer research : an official journal of the American Association for Cancer Research
Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research
Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Activated stat-3 in melanoma.
Cancer control : journal of the Moffitt Cancer Center
Identifying clinically meaningful fatigue with the Fatigue Symptom Inventory.
Journal of pain and symptom management
Exploring the differential experience of breast cancer treatment-related symptoms: a cluster analytic approach.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Phase I trial of poly-L-glutamate camptothecin (CT-2106) administered weekly in patients with advanced solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Physical symptoms/side effects during breast cancer treatment predict posttreatment distress.
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety.
Cancer chemotherapy and pharmacology
Utility of a cognitive-behavioral model to predict fatigue following breast cancer treatment.
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
Discussion of fertility preservation with newly diagnosed patients: oncologists' views.
Journal of cancer survivorship : research and practice
First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Increased bioavailability of intravenous versus oral CI-1033, a pan erbB tyrosine kinase inhibitor: results of a phase I pharmacokinetic study.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial.
Molecular cancer therapeutics
Overall and progression-free survival in metastatic melanoma: analysis of a single-institution database.
Cancer control : journal of the Moffitt Cancer Center
Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Arzoxifene: the development and clinical outcome of an ideal SERM.
Expert opinion on investigational drugs
In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates.
Molecular cancer therapeutics
Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta.
Clinical cancer research : an official journal of the American Association for Cancer Research
Chinese herbal formula, Bing De Ling, enhances antitumor effects and ameliorates weight loss induced by 5-fluorouracil in the mouse CT26 tumor model.
DNA and cell biology
Valproic acid alters chromatin structure by regulation of chromatin modulation proteins.
Cancer research
Phase II trial of karenitecin in patients with malignant melanoma: clinical and translational study.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid.
Journal of cellular biochemistry
Phase II, randomized, double-blind study of two dose levels of arzoxifene in patients with locally advanced or metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Chemotherapy-induced amenorrhea and fertility in women undergoing adjuvant treatment for breast cancer.
Cancer control : journal of the Moffitt Cancer Center
Improving breast cancer care.
Cancer control : journal of the Moffitt Cancer Center
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells.
Cancer research
Tamoxifen vs the aromatase inhibitors: news from San Antonio, 2001.
Cancer control : journal of the Moffitt Cancer Center
Predictive factor for the response to adjuvant therapy with emphasis in breast cancer.
Breast cancer research : BCR
New drugs in gynecologic cancer.
Current treatment options in oncology
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.
Chemistry & biology
Update on the management of advanced breast cancer.
Oncology (Williston Park, N.Y.)