Gregory Allen, MD, PhD

Asst Professor In Residence
Primary Thematic Area
M_MED-CORE-HMON-ONCO-GEN
Secondary Thematic Area
Research Summary
Our group develops and applies advances in synthetic biology to better understand biological systems and then to re-engineer these systems to tackle disease.

Greg Allen, MD/PhD is a physician-scientist specializing in designing and translating next-generation immune cell therapies for solid tumors. He cares for patients with lung cancer at the Hellen Diller Cancer Center and runs a research laboratory at the Parker Institute for Cancer Immunotherapy.

The Allen Lab is focused on developing and applying advanced synthetic biology tools to dissect the fundamental design principles of the immune system. We use synthetic receptors, cytokines, and secondary messengers to generate novel alternatively engineered tumor-immune eco-systems, which we then interrogate with high-dimensional tools. From this ground-up systems biology perspective we are attempting to rationally design engineered cells to tackle the most challenging diseases we face in the clinic.

Publications

Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: A Phase II Multicenter Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Blakely CM, Urisman A, Gubens MA, Mulvey CK, Allen GM, Shiboski SC, Rotow JK, Chakrabarti T, Kerr DL, Aredo JV, Bacaltos B, Gee M, Tan L, Jones KD, Devine WP, Doebele RC, Aisner DL, Patil T, Schenk EL, Bivona TG, Riess JW, Coleman M, Kratz JR, Jablons DM