Kevan Shokat, PhD

Professor

Cellular Molecular Pharmacology

[email protected]

+1 415 514-0472

Primary Thematic Area:

Cancer Biology & Cell Signaling

Secondary Thematic Area:

Neurobiology

Research Summary:

The Shokat lab uses chemical genetics to study and target signaling proteins, with the aim of finding new ways to treat human diseases.

Publications:

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

Cancer research

Turnham RE, Pitea A, Jang GM, Xu Z, Lim HC, Choi AL, Von Dollen J, Levin RS, Webber JT, McCarthy E, Hu J, Li X, Che L, Singh A, Yoon A, Chan G, Kelley RK, Swaney DL, Zhang W, Bandyopadhyay S, Theis FJ, Eckhardt M, Chen X, Shokat KM, Ideker T, Krogan NJ, Gordan JD

Direct RAS inhibitors turn 10.

Nature chemical biology

Ostrem JML, Peters U, Shokat KM

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.

Proceedings of the National Academy of Sciences of the United States of America

Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.

Cell

Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM

IL-13 and IL-17A activate ß1 integrin through an NF-kB/Rho kinase/PIP5K1? pathway to enhance force transmission in airway smooth muscle.