Associate Professor
Primary Thematic Area
M_Dermatology
Secondary Thematic Area
Research Summary
Our overarching goal is to understand the biology of skin cancer with an emphasis on melanoma and squamous cell carcinoma.
Our laboratory studies the genomic landscape and evolution of skin cancer. We use bulk-cell and single-cell DNA/RNA sequencing as well as spatial transcriptomics to track tumor evolution. We lead one of the research centers in the Human Tumor Atlas Network (HTAN). We are interested in the genetic and non-genetic factors driving cancer progression. We are always interested in adopting the latest -omic technologies.
Websites
Publications
The Genetic Evolution of Melanoma from Precursor Lesions.
The New England journal of medicine
The genetic evolution of metastatic uveal melanoma.
Nature genetics
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
Nature genetics
From melanocytes to melanomas.
Nature reviews. Cancer
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America