Professor, Anatomy
Director, Bakar Aging Research Institute
Primary Thematic Area
M_Anatomy
Secondary Thematic Area
Research Summary
Defining conserved mechanisms regulating stem cell behavior and how these are altered with age and in response to chronic or acute changes in metabolism.
+1 415 476-4622
The Jones Lab primary goal is characterizing fundamental mechanisms that are involved in regulating stem cell behavior. Once such mechanisms are established, we are interested in understanding how these mechanisms are altered by organismal aging or chronic or acute changes in metabolism, leading to age-onset diseases, such as cancer.
Websites
Publications
Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis.
Nature cell biology
Mitochondrial fusion regulates lipid homeostasis and stem cell maintenance in the Drosophila testis.
Nature cell biology
EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis.
Cell reports
DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging.
Cellular and molecular gastroenterology and hepatology