Ralph Marcucio, PhD

Department of Orthopaedic Surgery
+1 415 206-5366

First, using cutting-edge genomic technology, Dr. Marcucio is examining how the entire genome responds to orthopaedic trauma. This genome-mining approach is aimed at determining the global genome response during fracture repair and allows the possibility to generate improved, highly innovative therapies for people undergoing fracture repair. Second, Ralph is examining the role that the brain plays during normal development of the facial skeleton. Many facial birth defects have an underlying brain malformation, and the goal of the research is to generate novel therapeutic approaches that will allow correcting facial malformations prior to birth.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Research Summary: 
Craniofacial development, evolutionary biology, trauma, bone repair, angiogenesis



Reverse engineering development: crosstalk opportunities between developmental biology and tissue engineering.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Marcucio RS, Qin L, Alsberg E, Boerckel JD

Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing?

Frontiers in cell and developmental biology

Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T

Shaping the sound of voice.


Marcucio R

Craniofacial diversification in the domestic pigeon and the evolution of the avian skull.

Nature ecology & evolution

Young NM, Linde-Medina M, Fondon JW, Hallgrímsson B, Marcucio RS

The society for craniofacial genetics and developmental biology 39th annual meeting.

American journal of medical genetics. Part A

Fish JL, Albertson C, Harris MP, Lozanoff S, Marcucio RS, Richtsmeier JT, Trainor PA