Ralph Marcucio, PhD

Professor
Department of Orthopaedic Surgery
+1 628 206-5366
Research Overview: 

First, using cutting-edge genomic technology, Dr. Marcucio is examining how the entire genome responds to orthopaedic trauma. This genome-mining approach is aimed at determining the global genome response during fracture repair and allows the possibility to generate improved, highly innovative therapies for people undergoing fracture repair. Second, Ralph is examining the role that the brain plays during normal development of the facial skeleton. Many facial birth defects have an underlying brain malformation, and the goal of the research is to generate novel therapeutic approaches that will allow correcting facial malformations prior to birth.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
None
Research Summary: 
Craniofacial development, evolutionary biology, trauma, bone repair, angiogenesis

Websites

Publications: 

Dosage-dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses.

Anatomical record (Hoboken, N.J. : 2007)

Richbourg HA, Vidal-García M, Brakora KA, Devine J, Takenaka R, Young NM, Gong SG, Neves A, Hallgrímsson B, Marcucio RS

Genetic architecture of trait variance in craniofacial morphology.

Genetics

Andrade F, Howell L, Percival CJ, Richtsmeier JT, Marcucio RS, Hallgrímsson B, Cheverud JM

Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses.

Scientific data

Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B

The Developmental Basis for Evolvability.

Evolvability

Benedikt Hallgrímsson, J. David Aponte, Marta Vidal-Garcia, Heather Richbourg, Rebecca Green, Nathan M. Young, James M. Cheverud, Anne L. Calof, Arthur D. Lander, Ralph S. Marcucio

Encapsulation of ß-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.

Frontiers in bioengineering and biotechnology

Rivera KO, Cuylear DL, Duke VR, O'Hara KM, Zhong JX, Elghazali NA, Finbloom JA, Kharbikar BN, Kryger AN, Miclau T, Marcucio RS, Bahney CS, Desai TA