Frederick Chang, PhD, MD

Department of Cell & Tissue Biology
Research Description: 

The Chang Lab studies fundamental questions concerning spatial organization within a single cell: How are cell shape and size determined? How do cells sense their own size, or their shape? How do molecular dynamics and cell mechanics contribute to determine the growth, size and shape of cells? To address these questions, we study primarily the fission yeast Schizosaccharomyces pombe. These are rod-shaped eukaryotic cells that display a highly uniform size and morphology. Many of our studies use live cell imaging and image analyses to develop quantitative models. Current projects include: regulation of cell size and growth, cytoplasmic density and turgor pressure, cell wall assembly, cytokinesis, and microtubule regulation. We use interdisciplinary approaches, combining the expertise and perspectives of cell biologists, geneticists, physicists, engineers and modelers.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
We study the regulation of cell size and shape in fission yeast S. pombe



Forces that shape fission yeast cells.

Molecular biology of the cell

Chang F

Morphogenesis of the Fission Yeast Cell through Cell Wall Expansion.

Current biology : CB

Atilgan E, Magidson V, Khodjakov A, Chang F

Electrochemical regulation of budding yeast polarity.

PLoS biology

Haupt A, Campetelli A, Bonazzi D, Piel M, Chang F, Minc N

The contractile ring coordinates curvature-dependent septum assembly during fission yeast cytokinesis.

Molecular biology of the cell

Zhou Z, Munteanu EL, He J, Ursell T, Bathe M, Huang KC, Chang F

How and why cells grow as rods.

BMC biology

Chang F, Huang KC