Bruce Wang, MD

Associate Prof In Residence
Department of Medicine - Gastroenterology
Primary Thematic Area
Secondary Thematic Area
Research Summary
We study how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury.

My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.

Publications

Accessibility and harmonization of biochemical tests for diagnosis and monitoring of Porphyrias in the United States: Recommendations by members of the American Porphyrias Expert Collaborative (APEX).

Molecular genetics and metabolism

Anderson KE, Desnick RJ, Bonkovsky HL, Balwani M, Barnes S, Beaven SW, Yeung AK, Erwin AL, Freeman M, Huda R, Kazamel M, Leaf RK, Keel SB, Levy C, Mazepa M, McGuire B, Moghe A, Naik H, Parker CJ, Phillips JD, Quigley JG, Ramanujam VS, Rudnick SR, Thapar M, Vercellotti GM, Wheeden K, Wang B, Yasuda M

NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1-NEDD8 pathway.

Hepatology (Baltimore, Md.)

Zapata-Pavas LE, Serrano-Macia M, Merlos Rodrigo MÁ, Barrenechea-Barrenechea JA, Peña-SanFelix P, Del Río-Álvarez Á, Gil-Pitarch C, Rejano-Gordillo CM, Goikoetxea-Usandizaga N, González-Recio I, Michalkova H, Mercado-Gómez M, Lachiondo-Ortega S, Castañeda A, Asensio M, Murti A, Lelou E, Nogueiras R, Mayor U, Heger Z, Sancho-Bru P, Delgado TC, Calvisi DF, Xirodimas DP, Wang B, Marin JJG, Fernandez-Barrena MG, Armengol C, Ávila M, Martínez-Chantar ML

Towards a reference cell atlas of liver diversity over the human lifespan.

Nature reviews. Gastroenterology & hepatology

Taylor SA, Bader GD, MacParland S, Mullen AC, Andrews T, Cuenca AG, DasGupta R, Gehring AJ, Grün D, Guilliams M, Gulamhusein A, Henderson NC, Hirschfield G, Huppert SS, Itzkovitz S, Jiang ZG, Lauer GM, McGilvray I, Mysore KR, Pirola CJ, Quon G, Rahbari M, Regev A, Ricciuto A, Scott CL, Sharma A, Sookoian S, Tana MM, Teichmann SA, Vallier L, Vlachos IS, Wang B, Zhen M

A molecular cell atlas of mouse lemur, an emerging model primate.

Nature

Tabula Microcebus Consortium, Ezran C, Liu S, Chang S, Ming J, Botvinnik O, Penland L, Tarashansky A, de Morree A, Travaglini KJ, Zhao J, Wang G, Hasegawa K, Sin H, Sit R, Okamoto J, Sinha R, Zhang Y, Karanewsky CJ, Pendleton JL, Morri M, Perret M, Aujard F, Stryer L, Artandi S, Fuller MT, Weissman IL, Rando TA, Ferrell JE, Wang B, De Vlaminck I, Yang C, Casey KM, Albertelli MA, Pisco AO, Karkanias J, Neff N, Wu AR, Quake SR, Krasnow MA

Mouse lemur cell atlas informs primate genes, physiology and disease.

Nature

Ezran C, Liu S, Chang S, Ming J, Guethlein LA, Wang MFZ, Dehghannasiri R, Olivieri J, Frank HK, Tarashansky A, Koh W, Jing Q, Botvinnik O, Antony J, Tabula Microcebus Consortium, Pisco AO, Karkanias J, Yang C, Ferrell JE, Boyd SD, Parham P, Long JZ, Wang B, Salzman J, De Vlaminck I, Wu AR, Quake SR, Krasnow MA

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.

Science (New York, N.Y.)

Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Pisco AO, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Crasta S, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kolluru S, Kong W, Kumar ME, Kuo AH, Leylek R, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Morri M, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Phansalkar R, Pisco AO, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Travaglini KJ, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Tan SY, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Detweiler AM, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, de Morree A, Olivieri JE, Park M, Pisco AO, Ravikumar N, Salzman J, Stanley G, Swift M, Tan M, Tan W, Tarashansky AJ, Vanheusden R, Vorperian SK, Wang P, Wang S, Xing G, Xu C, Yosef N, Alcántara-Hernández M, Antony J, Chan CKF, Chang CA, Colville A, Crasta S, Culver R, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Kershner AM, Kong W, Kumar ME, Kuo AH, Leylek R, Liu S, Loeb GB, Lu WJ, Maltzman JS, Metzger RJ, de Morree A, Neuhöfer P, Perez K, Phansalkar R, Qi Z, Rao P, Raquer-McKay H, Sasagawa K, Scott B, Sinha R, Song H, Spencer SP, Swarup A, Swift M, Travaglini KJ, Trimm E, Veizades S, Vijayakumar S, Wang B, Wang W, Winkler J, Xie J, Yung AR, Artandi SE, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Krasnow M, Kuo CS, Nguyen P, Quake SR, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wang B, Wu A, Wu SM, Wyss-Coray T

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.

The New England journal of medicine

Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder E, Horie Y, Penz C, Chen J, Liu S, Ko JJ, Sweetser MT, Garg P, Vaishnaw A, Kim JB, Simon AR, Gouya L