Jing Chung (student)
"Taming IL-2 with acidity: an IL-2 mutein with pH-specific anti-tumor activity."
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. PMID: 36459543.
Coaches: Max Krummel, PhD & Matt Spitzer, PhD
Madison Lotstein (student)
"Shooting for the Stars with STARmap PLUS"
Zeng, H., Huang, J., Zhou, H. et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease. Nat Neurosci 26, 430–446 (2023). https://doi.org/10.1038/s41593-022-01251-x
Coaches: Andrew Yang, PhD & Marina Sirota, PhD