Iris Chin (Student)
"I(GF2R) don’t know about you, but I’m feeling (CD)22: A role for sCD22 and IGF2R in microglial lysosome dysfunction"
Pluvinage, J. V., Sun, J., Claes, C., Flynn, R. A., Haney, M. S., Iram, T., Meng, X., Lindemann, R., Riley, N. M., Danhash, E., Chadarevian, J. P., Tapp, E., Gate, D., Kondapavulur, S., Cobos, I., Chetty, S., Pașca, A. M., Pașca, S. P., Berry-Kravis, E., Bertozzi, C. R., Blurton-Jones, M., Wyss-Coray, T. (2021). The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick Type C. Science Translational Medicine, 13(622):eabg2919.
Coaches: Martin Kampmann, PhD & Lennart Mucke, MD
Stephanie Huard (Student)
"Microglia in the Middle: Trem2 in Alzheimer's Pathogenesis"
Lee SH, Meilandt WJ, Xie L, Gandham VD, Ngu H, Barck KH, Rezzonico MG, Imperio J, Lalehzadeh G, Huntley MA, Stark KL, Foreman O, Carano RAD, Friedman BA, Sheng M, Easton A, Bohlen CJ, Hansen DV. Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology. Neuron. 2021 Apr 21;109(8):1283-1301.e6. doi: 10.1016/j.neuron.2021.02.010. Epub 2021 Mar 5. PMID: 33675684.
Coaches: Carlo Condello, PhD & Balyn Zaro, PhD