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BMS Journal Club

2015-16 Schedule

September 3, 2015-June 2, 2016

Journal Club Chairs: Mike German, MD and Suzanne Noble, MD, PhD
Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room
MH-1405, Mission Bay.
Live stream & archive: Spring 2016, Winter 2016, Fall 2015, Summer 2015 (9/3) (UCSF MyAccess login required)

September 3, 2015
Mission Bay videoconference: MH-1405
Adair Borges (student)
“Inducing MDT before it was cool: Hip(ster)BA - promoter structures reveal the basis of heritable multidrug tolerance”
Schumacher MA et al. HipBA-promoter structures reveal the basis of heritable multidrug tolerance. Nature. 2015 Aug 6;524(7563):59-64. doi: 10.1038/nature14662.
Coaches: Joseph Bondy-Denomy and Jeffrey Cox

Oren Rosenberg (faculty)
"Hybrid Approaches to Understand Complex, Macromolecular Machines"
Durand E et al. Biogenesis and structure of a type VI secretion membrane core complex. Nature. 2015 Jul 22;523(7562):555–60.

September 10, 2015
Mission Bay videoconference: MH-1405
Eric Wigton (student)
"Micey's Mom Has Got it Going on:  Maternal Microchimerism Enforces Cross Generational Reproductive Fitness."
Kinder JM et al. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell. 2015 July 30; 162 (3) 505–515. doi:10.1016/j.cell.2015.07.006
Coaches: Trevor Burt and Mark Ansel

Jason Cyster (faculty)
"VISTA of death: p53-induced gene promotes apoptotic cell clearance."
Yoon KW et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 July 31:349 (6247) doi: 10.1126/science.1261669.

September 17, 2015
Mission Bay videoconference: MH-1405
Corey Tan (student)
"Use the (replication) forks: T cell help controls cell cycle speed in germinal center B cells."
Gitlin A et al. T cell help controls the speed of the cell cycle in germinal center B cells. Science. 2015 Aug 7;349(6248):643-646.
Coaches: Julie Zikherman and Jason Cyster

Julie Sneddon
“It’s Just a Flesh Wound: Identification and Isolation of a Dermal Lineage with Intrinsic Fibrogenic Potential.”
Rinkevich Y, et al. Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential. Science. 2015; Apr 17;348(6232):aaa2151. doi: 10.1126/science.aaa2151.

September 24, 2015
Mission Bay videoconference: MH-1405
Luke Smith
"Survival of the fittest: how competition for cadherin/catenin complexes determines dendritic spine fate."
Bian WJ, et al. Coordinated spine pruning and maturation mediated by inter-spine competition for cadherin/catenin complexes. Cell. 2015; 162, 808-822.
Coaches: Saul Villeda and Erik Ullian

Diana Laird
"Why wait? Start defying your parents even before (their) birth!"
Tang WW, et al. A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development. Cell. 2015 Jun 4;161(6):1453-67. doi: 10.1016/j.cell.2015.04.053.

October 1, 2015

Mission Bay videoconference: MH-1405
Elze Rackaityte (student)
"That’s so random! Stochastic pathogen cell-to-cell variability drives heterogeneity in host immune responses."
Avraham R, et al. Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses. Cell. 2015 Sep 2. pii: S0092-8674(15)01041-7. doi: 10.1016/j.cell.2015.08.027.
Coaches: Oren Rosenberg and Joseph Bondy-Denomy

Andrew Brack (faculty)
"Stem cell quiescence and injury sensing."
Rodgers JT, et al. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19;510(7505):393-6. doi: 10.1038/nature13255.

October 8, 2015
Mission Bay videoconference: MH-1405
Andrew Mancini (student)
"Dumpster diving for dCTPs: CDA-directed metabolism of epigenetic nucleosides in cancer."
Zauri M, et al. CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature. 2015 Aug 6. 524(7563):114-8. doi: 10.1038/nature14948.
Coaches: Andrei Goga and Aaron Tward

Jorge Ortiz-Carpena (student)
"Craigslist Buddies for mRNAs: Spatiotemporal dynamics of inflammatory mRNA regulation mediated by Regnase-1 and Roquin."
Mino T, et al. Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms. Cell. 2015; 161, 1058-1073.
Coaches: Mark Ansel and Clifford Lowell

October 15, 2015
Mission Bay videoconference: MH-1405
Erick Lu (student)
"A trail of breadcrumbs: Neutrophil-derived cellular fragments promote CD8+ T cell migration during influenza."
Lim K, et al. Neutrophil trails guide influenza-specific CD8+ T cells in the airways. Science. 2015 Sep 4; 349 (6252) doi: 10.1126/science.aaa4352.
Coaches: Jason Cyster and Shaeri Mukherjee

Saul Villeda (faculty)
"There’s something fishy about aging."
Harel I, et al. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate. Cell. 2015 Feb 26;160(5):1013-26. doi: 10.1016/j.cell.2015.01.038.

October 22, 2015
Mission Bay videoconference: MH-1405
Abby Kindberg (student)
"A Tense Situation: The Role of Cortical Tension in Early Embryo Development."
Samarage CR, et al. Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo. Dev Cell. 2015 Aug 24;34(4):435-47. doi: 10.1016/j.devcel.2015.07.004.
Coaches: Jeff Bush and Susan Fisher

JJ Miranda (faculty)
"Don’t turn around, ‘cause you’re gonna see my heart breaking."
Guo Y, et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 2015 Aug 13;162(4):900-10. doi: 10.1016/j.cell.2015.07.038.

October 29, 2015
Mission Bay videoconference: MH-1405
Natanya Kerper
Title TBD
Zhu X, et al. Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells. Dev Cell. 2015 Sep 28;34(6):656-68. doi: 10.1016/j.devcel.2015.08.020.
Coaches: Matthias Hebrok and Torsten Wittman

Melanie Ott
"SECcessful viral culture: SEC14L2 enables pan-genotype HCV replication in cell culture."
Saeed M, et al. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature. 2015 Aug 27;524(7566):471-5. doi: 10.1038/nature14899.

November 5, 2015
Mission Bay videoconference: MH-1405
Ariel Kauss
"What's in a Niche? Two models of hepatic regeneration."
Font-Burgada, et al. Hybrid Periportal Hepatocytes Regenerate to the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13;162(4):766-79. doi: 10.1016/j.cell.2015.07.026.
Wang B, et al. Self Renewing diploid Axin2+ cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13;524(7564):180-5. doi: 10.1038/nature14863.
Coaches: Todd McDevitt and Holger Willenbring

Rosemary Akhurst (faculty)
"Tumor Neoantigens in Immunotherapy: Quality or Quantity?"
Van Allen E, et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science. 2015 Oct 9;350(6257):207-11. doi: 10.1126/science.aad0095.

November 12, 2015
Mission Bay videoconference: MH-1405
Emily Jones
"Fingerprint Your Brain: How a Few MRIs Might Identify You and Predict Your Intelligence."
Finn ES, et al. Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nat Neurosci. 2015 Nov;18(11):1664-71. doi: 10.1038/nn.4135.
Coaches: Yadong Huang and Aimee Kao

Ethan Weiss
"What does GH stand for? A new twist on an old and important UCSF story."
Brooks AJ, et al. Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor. Science. 2014 May 16;344(6185):1249783. doi: 10.1126/science.1249783.

November 19, 2015
Mission Bay videoconference: MH-1405
Bernadette Hsu
"3D organoids: A new way to personalize pancreatic cancer."
Huang L, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat Med. 2015 Oct 26. doi: 10.1038/nm.3973.
Coaches: Holger Willenbring and Rushika Perera

Pamela Munster
"More news with Immunotherapy."
Le DT, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med. 2015 Jun 25;372(26):2509-20. doi: 10.1056/NEJMoa1500596.

December 3, 2015
Mission Bay videoconference: MH-1405
Dror Assa
"Taking the STING out."
Wu Jj, et al. Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein. Cell Host Microbe. 2015 Sep 9;18(3):333-44. doi: 10.1016/j.chom.2015.07.015. Epub 2015 Aug 27.
Coaches: Anita Sil and Anthony DeFranco

Lily Jan
"A refreshingly new potassium channel."
Cang C, et al. TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. Cell. 2015 Aug 27;162(5):1101-12. doi: 10.1016/j.cell.2015.08.002.

January 7, 2016
Mission Bay videoconference: MH-1405
Qi Yan Ang
"Bacteria come into focus: New tool for imaging gut microbiota spatial organization."
Earle KA, et al. Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe. 2015 Oct 14;18(4):478-88. doi: 10.1016/j.chom.2015.09.002.
Coaches: Kurt Thorn and Peter Turnbaugh

Ying-Hui Fu (faculty)
"How much time can a cup of coffee get for you?"
Burke TM, et al. Effects of caffeine on the human circadian clock in vivo and in vitro. Sci Transl Med. 2015 Sep 16;7(305):305ra146. doi: 10.1126/scitranslmed.aac5125.

January 14, 2016
Mission Bay videoconference: MH-1405
Sophia Levan
"Which one's the chicken? Interrupting the Host-Microbe Interface."
Levy, M. et al. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell 163, 1428–1443 (2015).
Coaches: Suzanne Noble and Tony DeFranco

Peter Turnbaugh
"Where does your microbiome go when you die?"
Metcalf JL, et al. Microbial community assembly and metabolic function during mammalian corpse decomposition. Online December 10 2015, Science  DOI: 10.1126/science.aad2646.

January 21, 2016
*Special Time - 5:00 pm.*
** There will be no videoconference to Mission Bay for this session. **
Francesca Aloisio (student)
"Capping Optional Beyond This Point: 5' UTR m6A promotes cap-independent translation."
Meyer, K. et al. 5' UTR m6A Promotes Cap-Independent Translation. Cell 163, 999-1010 (2015).
Coaches: Michael McManus and Davide Ruggero

Akiko Hata
"Fibrodysplasia Ossificans Progressive (FOP)—the disease of mismatched relationship."
Hatsell SJ, et al. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015 Sep 2;7(303):303ra137. doi: 10.1126/scitranslmed.aac4358.

January 28, 2016
Mission Bay videoconference: MH-1405
Jennifer Liu
"Autophagy-mediated degradation of nuclear lamina: a new role for self-eating."
Dou Z, et al. Autophagy mediates degradation of nuclear lamina. Nature. 2015 Nov 5;527(7576):105-9. doi: 10.1038/nature15548.
Coaches: Jay Debnath and Rushika Perera

TBD (faculty)

February 4, 2016
Mission Bay videoconference: MH-1405
Trisha Macrae
"Rethinking Meatless Mondays: a low-protein paternal diet affects small RNA levels in maturing sperm."
Sharma U, et al. Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science. Online 2015 Dec 31. doi: 10.1126/science.aad6780.
Coaches: Miguel Ramalho-Santos and Diana Laird

Scott Kogan
“Yet another link between proteostasis and (hematologic) neoplasia!”
Osorio FG, et al. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Nat Med. 2016 Jan;22(1):91-6. doi: 10.1038/nm.4013.

February 11, 2016
*Special Time - 5:00 pm.*
** There will be no videoconference to Mission Bay for this session. **
John Gagnon (student)
Lamarckian Inheritance of Acquired Traits: Back in Vogue?
Chen Q, et al. Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 2016 Jan 22;351(6271):397-400. doi: 10.1126/science.aad7977.
Coaches: Rob Judson and TBD

Michael Rosenblum
"Regulatory T cells - to be suppressive or not? That is the question."
Arpaia N, et al. A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 2015 Aug 27;162(5):1078-89. doi: 10.1016/j.cell.2015.08.021.

February 18, 2016
Mission Bay videoconference: MH-1405
Walter Mancia
Brandhorst S, et al. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012.
Coaches: Saul Villeda and Yin Shen

Daniel Bikle
"Who heals my fracture?"
Marecic O, et al. Identification and characterization of an injury-induced skeletal progenitor. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9920-5. doi: 10.1073/pnas.1513066112.

February 25, 2016
Mission Bay videoconference: MH-1405
Andrew McKinney

Yin Shen

March 3, 2016
Mission Bay videoconference: MH-1405
Andrew McNeal

Diane Barber
"Follow the glucose trail to find where to go."
Dupuy F, et al. PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer. Cell Metabolism (2015) 22:577–589.

March 10, 2016

Mission Bay videoconference: MH-1405
Lauren Meyer

Art Weiss

March 17, 2016
Mission Bay videoconference: MH-1405
Michelle Mintz (student)

Sarah McMahon (student)

March 24, 2016
Mission Bay videoconference: MH-1405
Tonatiuh Montoya (student)

Casey Beppler (student)

March 31, 2016
Mission Bay videoconference: MH-1405
Phi Nguyen (student)

Daniel Bunis (student)

April 7, 2016

Mission Bay videoconference: MH-1405
Ariane Panzer (student)

Carlos Castellanos (student)

April 14, 2016
Mission Bay videoconference: MH-1405
Mark-Phillip Pebworth (student)

Jessica Cortez (student)

April 21, 2016
Mission Bay videoconference: MH-1405
Hannah Retallack (student)

Emily Davis (student)

April 28, 2016
Mission Bay videoconference: MH-1405
Tina Solvik (student)

Andrea Eastes (student)

May 5, 2016
Mission Bay videoconference: MH-1405
Tina Tianjiao Su (student)

Kimberly Hoi (student)

May 12, 2016
Mission Bay videoconference: MH-1405
Sasha Targ (student)

Alana Horowitz (student)

May 19, 2016
Mission Bay videoconference: MH-1405
Daniel Wong (student)

Rebecca Jaszczak (student)

May 26, 2016
Mission Bay videoconference: MH-1405
Germaine Yong (student)

Ruiji Jiang (student)

June 2, 2016
Mission Bay videoconference: MH-1405
Tina Zheng (student)

Simone Kurial (student)