Nadav Ahituv, PhD

Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 476-1838
Research Description: 

The Ahituv lab is focused on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes including morphological differences between species, drug response and human disease. In addition, our lab is developing massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements and the use of gene regulatory elements as therapeutic targets or disease diagnostic markers.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Gene regulation and human disease
Mentorship Development: 

4/2019 - Acknowledging and Negotiating the Mentee-Mentor Tensions Inherent in the Research Lab
4/2019 - Sharpening your Mentoring Skills (SyMS) with Sharon Milgram
6/2020 - Your Role in Workplace Diversity
10/2020 - DEI Champion Training
2/2021 - Three Truths & Three Tries: Facing & Overcoming Critical Social Justice Challenges at the Micro, Mezzo & Macro Levels

Websites

Publications: 

The topography of nullomer-emerging mutations and their relevance to human disease.

Computational and structural biotechnology journal

Candace S.Y. Chan, Ioannis Mouratidis, Austin Montgomery, Georgios Christos Tsiatsianis, Nikol Chantzi, Martin Hemberg, Nadav Ahituv, Ilias Georgakopoulos-Soares

Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements.

Nature communications

Chardon FM, McDiarmid TA, Page NF, Daza RM, Martin BK, Domcke S, Regalado SG, Lalanne JB, Calderon D, Li X, Starita LM, Sanders SJ, Ahituv N, Shendure J

Deletion of an evolutionarily conserved TAD boundary compromises spermatogenesis in mice.

bioRxiv : the preprint server for biology

Lima AC, Okhovat M, Stendahl AM, VanCampen J, Nevonen KA, Herrera J, Li W, Harshman L, Yang R, Fedorov LM, Vigh-Conrad KA, Ahituv N, Conrad DF, Carbone L

Genetic regulation of cell type-specific chromatin accessibility shapes brain disease etiology.

Science (New York, N.Y.)

Zeng B, Bendl J, Deng C, Lee D, Misir R, Reach SM, Kleopoulos SP, Auluck P, Marenco S, Lewis DA, Haroutunian V, Ahituv N, Fullard JF, Hoffman GE, Roussos P