Michael Rosenblum, MD, PhD

Assistant Professor
Department of Dermatology
RosenblumMD@derm.ucsf.edu

The central focus of my lab is to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. To this end, we currently have two areas of active investigation:

  1. Understanding how regulatory T cells (Tregs) control immune responses in tissues
  2. Understanding the ‘alternative’ functions of Tregs in tissues

Approach
Because of its complex immunological properties, its accessibility, and potential for clinical translation, the skin is the model peripheral tissue that we currently study. Approximately 50% of our research employs a reductionist approach, utilizing transgenic animal models to ask fundamental questions of how the immune system functions in skin at both the cellular and molecular levels. The other half of our work focuses on doing functional immunology with human skin, human blood and humanized mice.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
None
Research Summary: 
Defining the cellular and molecular mechanisms of immune regulation in peripheral tissues

Websites

Publications: 

Warfarin-Associated Nonuremic Calciphylaxis.

JAMA dermatology

Yu WY, Bhutani T, Kornik R, Pincus LB, Mauro T, Rosenblum MD, Fox LP

Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.

The Journal of clinical investigation

Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach IV, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.

Journal of immunology (Baltimore, Md. : 1950)

Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD