Assistant Professor In Res
Primary Thematic Area
M_Otolaryngology
Secondary Thematic Area
Research Summary
We develop and apply functional genetic screening technologies to investigate anti-tumor immune function of human T cells.
Publications
Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.
bioRxiv : the preprint server for biology
Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
Communications biology
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.
Nature genetics
Bidirectional epigenetic editing reveals hierarchies in gene regulation.
Nature biotechnology
CRISPR activation and interference screens decode stimulation responses in primary human T cells.
Science (New York, N.Y.)
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Nature biotechnology
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Nature communications
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.
Proceedings of the National Academy of Sciences of the United States of America
Test performance evaluation of SARS-CoV-2 serological assays.
medRxiv : the preprint server for health sciences
IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
The Journal of cell biology
Wnt signaling in development and tissue homeostasis.
Development (Cambridge, England)
Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Nature medicine
Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors.
Nature medicine
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.
Journal of cell science
Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.
Proceedings of the National Academy of Sciences of the United States of America