2025-26 Journal Clubs

2025-26 Journal Club Schedule

Journal Club Co-Directors: Elizabeth Crouch, MD, PhDexternal site (opens in a new window) and Julia Carnevale, MDexternal site (opens in a new window)
Day/Time: Thursdays, 11:30 a.m - 12:30 p.m. except as noted
Location: In person on the Parnassus campus, with a livestream/Zoom option to Mission Bay as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs or can be accessed here: Zoom Linkexternal site (opens in a new window)


 

Please contact Meredith Miner if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.
 

See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.


 

Michael Alexanian, PhD (faculty)

Universal vs. Inflammatory: CRISPR Screens Uncover the Balancing Act of Fibroblast States

Southard, K.M., Ardy, R.C., Tang, A. et al. Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02284-1external site (opens in a new window)

Shirley Bi (student)

"Caught red-handed: an unmethylated retrotransposon adopts expression patterns of neighboring genes, leading to VLP generation and limb malformation."

Glaser, J., Cova, G., Fauler, B. et al. Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes. Nat Genet 57, 1766–1776 (2025).external site (opens in a new window)

Moderator: Alvin Ha

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 

Harish Vasudevan, MD, PhD (faculty)

"BindCraft: a new tool in the AI sandbox for protein interactor design"

Pacesa, M., Nickel, L., Schellhaas, C. et al. One-shot design of functional protein binders with BindCraft. Nature (2025). https://doi.org/10.1038/s41586-025-09429-6external site (opens in a new window)

Simon Wong (student)

"The Nerve to fight the flu: Vagal TRPV1+ neurons provide protection against Influenza virus through myeloid cells"

Nicole Almanzar et al. ,Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics.Sci. Immunol.10,eads6243(2025).DOI:10.1126/sciimmunol.ads6243external site (opens in a new window)

Moderator: Shania Garrison

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 


 

Joe Bondy-Denomy, PhD (faculty)

“Generative” phage: Are you entertained?

Samuel H. King, Claudia L. Driscoll, David B. Li, Daniel Guo, Aditi T. Merchant, Garyk Brixi, Max E. Wilkinson, Brian L. Hieexternal site (opens in a new window)
bioRxiv 2025.09.12.675911; doi: https://doi.org/10.1101/2025.09.12.675911external site (opens in a new window)

Liz Arouge (student)

"Treg Cells as Neuromodulators: Enkephalin Production by Regulatory T Cells Restrains Nociception and Skin Inflammation"

Alejandra Mendoza et al., Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception.Sci. Immunol.10,eadz6869(2025).DOI:10.1126/sciimmunol.adz6869external site (opens in a new window)

Coaches: Jarish Cohen, MD, PhD and Sakeen Kashem, MD, PhD

Moderator: Andrew Davis

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 

Phillip Dumesic, MD, PhD (faculty)

"Dynamic control of mammalian energy balance by the peroxisome"

Liu, X., He, A., Lu, D. et al. Peroxisomal metabolism of branched fatty acids regulates energy homeostasis. Nature (2025). https://doi.org/10.1038/s41586-025-09517-7external site (opens in a new window)

Dario Tagliaferri (student)

"Cutting Edge Fashion: A CRISPR Makeover"

Ruffolo, J.A., Nayfach, S., Gallagher, J. et al. Design of highly functional genome editors by modelling CRISPR–Cas sequences. Nature 645, 518–525 (2025). https://doi.org/10.1038/s41586-025-09298-zexternal site (opens in a new window)

Coaches: Greg Allen, MD, PhD and Justin Eyquem, PhD

Moderator: Caitlyn Dang

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 

Daniel Mordes, MD, PhD (faculty)

"Repeated head trauma causes neuron loss and inflammation in young athletes"

Butler MLMD, Pervaiz N, et al. Repeated head trauma causes neuron loss and inflammation in young athletes. Nature. 2025 Sep 17. doi: 10.1038/s41586-025-09534-6. Epub ahead of print. PMID: 40963024.external site (opens in a new window)

Michelle Seeler (student)

"Pregnancy takes Guts: Growth of the maternal intestine during reproduction"

Ameku, T., et al. (2025). "Growth of the maternal intestine during reproduction." Cell 188(10): 2738-2756.e2722external site (opens in a new window)

Coaches: Helen Willsey, PhD and Todd Nystul, PhD

Moderator: Jose Cedano

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 


 

Gabriel Loeb, MD, PhD (Faculty)

"Visualizing transcription factor dynamics at endogenous enhancers"

Hu, Y. et al. Multiscale footprints reveal the organization of cis-regulatory elements. Nature 638, 779–786 (2025).external site (opens in a new window)

Joseph Moreno (Student)

"TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells"

Dang, C., Kim, H., Santosa, E.K. et al. TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells. Nat Immunol 26, 1467–1475 (2025). https://doi.org/10.1038/s41590-025-02238-zexternal site (opens in a new window)

Coaches: Oscar Aguilar, PhD and Daniel Calabrese, MD

Moderator: Mandy Buck

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 


 


 

Anthony Khalifeh (student)

"Mapping the evolution of computationally designed protein binders"

Miguel A. Alcantar, Alexandra M. Paulk, et al. bioRxiv 2025.10.04.680454; doi: external site (opens in a new window)https://doi.org/10.1101/2025.10.04.680454external site (opens in a new window)

Coaches: Angela Phillips, PhD and Jeannette Tenthorey, PhD

Ananya Krishnapura (student)

"Unraveling the mechanisms underlying IRF7-mediated autoimmunity"

Fike AJ, Bricker KN, et al. IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints. J Exp Med. 2025 Jul 7;222(7):e20231882. doi: 10.1084/jem.20231882. Epub 2025 May 27. PMID: 40439584; PMCID: PMC12121627external site (opens in a new window)

Coaches: Julie Zikherman, MD and Jason Cyster, PhD

Moderator: Emily Chen

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 

Patrick Kennedy (Student)

"Disruption of the RAS–PI3Kα Interaction: A New Approach for Tumor Suppression"

Joseph E. Klebba et al. ,Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2.Science390,702-709(2025).DOI:external site (opens in a new window)10.1126/science.adv2684external site (opens in a new window) external site (opens in a new window)

Coaches: Harish Vasudevan, MD, PhD and Peter Bruno, PhD

Julia Johanssen (Student)

"The Naked (Mole-Rat) Truth about Aging"

Yu Chen et al.,A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging.Science390,eadp5056(2025).DOI:external site (opens in a new window)10.1126/science.adp5056external site (opens in a new window)

Coaches: Leanne Jones, PhD and Diana Laird, PhD

Moderator: Daniel Brody

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 


 


 

Alvin Ha (student)

TBD

Von Locquenghien, M et al. Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy Cell (2025), Volume 188, Issue 25, 7099 - 7117.e26external site (opens in a new window)

Coaches: Roarke Kamber, PhD and Brian Shy, MD, PhD

Helen Huynh (student)

"Pyruvate Fate as a Redox Switch for Cell Growth"

Toshniwal Ashish G, et al (2025) The fate of pyruvate dictates cell growth by modulating cellular redox potential eLife 13:RP103705. https://doi.org/10.7554/eLife.103705.2external site (opens in a new window)

Coaches: Isha Jain, PhD and Phillip Dumesic, MD, PhD

Moderators: Anthony Khalifeh & Julia Johanssen

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 

Shania Garrison (student)

"The Silver Lining to Going Grey: An Antagonistic Relationship Between Hair Greying and Melanoma"

Mohri, Y., Nie, J., Morinaga, H. et al. Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma. Nat Cell Biol 27, 1647–1659 (2025). https://doi.org/10.1038/s41556-025-01769-9external site (opens in a new window)

Coaches: Tien Peng, MD and Jose Angel Nicolas Avila, PhD

Rebecca Fulthorpe (student)

"From Risk to Resilience: Flipping the Allelic Switch against Alzheimer’s Disease"

Golden, L.R., Siano, D.S., Stephens, I.O. et al. APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition. Nat Neurosci 28, 2461–2475 (2025). https://doi.org/10.1038/s41593-025-02094-yexternal site (opens in a new window)

Coaches: Yadong Huang, MD, PhD and Andrew Yang, PhD

Moderators: Michelle Seeler & Angel Ruvalcaba

Location: HSW-302, Parnassus & MH-1405, Mission Bay


 

Andrew Davis (student)

"Red Light! Green Light!”: Developing a disease-agnostic therapy through tRNA editing 

Pierce, S.E., Erwood, S., Oye, K. et al. Prime editing-installed suppressor tRNAs for disease-agnostic genome editing. Nature 648, 191–202 (2025). https://doi.org/10.1038/s41586-025-09732-2external site (opens in a new window)

Coaches: Tippi MacKenzie, MD and Kyle Cromer, PhD

Christina Ekstrand (student)

“Say you’re Psorry!" Why your gut owes your skin an apology

Wang, Chenliang et al. (2025) external site (opens in a new window)Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells.external site (opens in a new window) Immunity, Volume 58, Issue 9, 2241 - 2255.e7external site (opens in a new window)

Coaches: Tiffany Scharschmidt, MD and James Gardner, MD, PhD

Moderators: Joseph Moreno & Paul Leclerc

 


 


 


 


 


 

Ana Coutlakis (student)

"Opening the Gates: EBV-Primed T Cells as Vascular Gatekeepers in Multiple Sclerosis"

Thomas, Olivia G. et al. Cell, Volume 189, Issue 2, 585 - 602.e38external site (opens in a new window)

Coaches: Melanie Ott, MD, PhD and Rachel Rutishauser, MD, PhD

Sena Cinar (student)

"Same Cells, Different Addresses: Spatially Programmed Innate Lymphoid Cells"

Werner, A. et al. Spatial and functional diversity of innate lymphoid cells in the human female genital tract may contribute to antiviral responses to HIV. Nat Immunol 26, 2030–2044 (2025).external site (opens in a new window)

Coaches: Ari Molofsky, MD, PhD and Nadia Roan, PhD

Moderators: Helen Huynh & Gilbert Herrera

 


 

Daniel Zhang (student)

"Double Time, Double Trouble: Whole Genome Duplication Keeps Ovarian Cancer One Step Ahead"

McPherson, A., Vázquez-García, I., Myers, M.A. et al. Ongoing genome doubling shapes evolvability and immunity in ovarian cancer. Nature 644, 1078–1087 (2025). external site (opens in a new window)https://doi.org/10.1038/s41586-025-09240-3external site (opens in a new window)

Coaches: Alejandro Sweet-Cordero, MD and Joseph Costello, PhD

Zimo Zhang (student)

"From Gut to Brain: The Role of Intestinal Macrophages in Parkinson's Disease"

De Schepper, S., Konstantellos, V., Conway, J.A. et al. Intestinal macrophages modulate synucleinopathy along the gut–brain axis. Nature (2026). external site (opens in a new window)https://doi.org/10.1038/s41586-025-09984-yexternal site (opens in a new window)

Coaches: Anna Molofsky, MD, PhD and Roarke Kamber, PhD

Moderators: Hana Takei & Adam Kazerounian


 


 


 


 

Venus Hagan (student)

"Code Switching: Lymphoid-Like Microglia Protect Against Alzheimer's Disease"

Ayata, P., Crowley, J.M., Challman, M.F. et al. Lymphoid gene expression supports neuroprotective microglia function. Nature 648, 157–165 (2025). external site (opens in a new window)https://doi.org/10.1038/s41586-025-09662-zexternal site (opens in a new window)

Coaches: Carlo Condello, PhD and Martin Kampmann, PhD

Adam Fillion (student)

"The Pigmented Swarm: Melanoma-derived Extracellular Decoys as a means of Immune Evasion"

Chemla, Yoav et al. HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion Cell, Volume 189, Issue 1, 233 - 251.e29 DOI: 10.1016/j.cell.2025.11.020external site (opens in a new window)

Coaches: Greg Allen, PhD and Magnus Hoffmann, PhD

Moderators: Katie Herm & Annika Mittelhauser


 

Katie Herm (student)

"Gaps in the Wall: Pericyte Dysfunction as an Early Event in Diabetic Islet Deterioration"

Luciana Mateus Gonçalves,et al; Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of β-Cell Loss and Low-Grade Inflammation. Diabetes 1 January 2026; 75 (1): 70–84. https://doi.org/10.2337/db25-0368external site (opens in a new window)

Coaches: Julie Sneddon, PhD and Serine Avagyan, MD, PhD

Gilbert Herrera (student)

"The Upside of a Sticky Situation: Multicellular ‘Doublets’ Reveal Potent Anti-Tumor T Cells"

Ibáñez-Molero, S., Veldman, J., Simon Nieto, J. et al. Tumour-reactive heterotypic CD8 T cell clusters from clinical samples. Nature 649, 467–476 (2026)external site (opens in a new window)

Coaches: Matt Spitzer, PhD and Simone Minnie, PhD

Moderators: Venus Hagen & Claire Rammel


 

Chang Liu (student)
"Finding the proverbial needle in a haystack: Mapping Antigen-specific TCRs"

Gaglione, Stephanie A. et al. Immunity, Volume 0, Issue 0external site (opens in a new window)

Coaches: Peter Bruno, PhD and Zachary Steinhart, PhD

Adam Kazerounian (student)

"Whodunnit? RNA Foci vs. DPR Proteins in Amyotrophic Lateral Sclerosis (ALS)"

Jiang, X., et al. (2026). Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes. Science, 391(6785), eadv2600. https://doi.org/10.1126/science.adv2600external site (opens in a new window)

Coaches: Biswarathan Ramani, PhD and Tomasz Nowakowski, PhD

Moderators: Jenny Liu & Jack Reid

exceptionally held at S-214 due to HVAC issue


 

Jenny Liu (student)

"TMI (Too Much Immunosuppression) for the TME: Modulating the tumor-microenvironment by depleting pro-tumor TAMs"

Mateus-Tique, J. et al. Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth. Cancer Cell 44, 534-550.e11 (2026). https://doi.org/10.1016/j.ccell.2025.12.021external site (opens in a new window)

Coaches: Greg Allen, MD, PhD and Roarke Kamber, PhD

Anjeli Mase (student)

"Taking the backroads: IFNy closes melanoma’s metastatic highway"

Karakousi, T., et al. (2026). IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma. Cancer Cell. https://doi.org/10.1016/j.ccell.2025.12.019external site (opens in a new window)

Coaches: Karin Pelka, PhD and Greg Allen, PhD

Moderators: Chang Liu & Alessandra Veinbachs


 

Barbara Perez (student)

"The Targets Were There All Along: Ultra Sensitive Receptors Unlock a New Class of Solid Tumor Targets"

Coaches: Justin Eyquem, PhD and Greg Allen, MD, PhD
 

Annika Mittelhauser (student)

"Feel the BEAT: Bispecific Exosome Activators of T Cells Orchestrate an Attack on Metastatic Melanoma"

Liu, S., Liu, M., Wang, Z. et al. Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma. Nat Biotechnol (2026). https://doi.org/10.1038/s41587-025-02890-8external site (opens in a new window)

Coaches: Matt Spitzer, PhD and Zach Steinhart, PhD

Moderators: Ana Coutlakis & Leighton Pu


 


 

Alessandra Veinbachs (student)

"Phone-a-(long distance) friend: Lesion-remote astrocytes support microglial white matter repair"

McCallum, S., Suresh, K.B., Islam, T.S. et al. Lesion-remote astrocytes govern microglia-mediated white matter repair. Nature 649, 959–970 (2026). https://doi.org/10.1038/s41586-025-09887-yexternal site (opens in a new window)

Coaches: Ari Molofsky, MD, PhD and Anna Molofsky, MD, PhD

Jack Reid (student)

"Color Theory: Fine-tuned Control of Cell Decisions"

An, B., Tang, TC., Zhang, Q. et al. Synthetic circuits for cell ratio control. Nature (2026). external site (opens in a new window)https://doi.org/10.1038/s41586-026-10259-3external site (opens in a new window)

Coaches: Julia Carnevale, MD and Roarke Kamber, PhD

Moderators: Anjeli Mase & Sena Cinar