Date:
February 3, 2022
Demi Sandel (Student)
"Targeting epigenetic programs to evade exhaustion"
Prinzing, Brooke et al. “Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.” Science translational medicine,(2021).
Coaches: Rachel Rutishauser, MD, PhD & Matt Spitzer, PhD
Laura Dwyer (Student)
"Biochem 101: MTHFD2's role in T cell fate, function, and metabolism"
Sugiura, A., Andrejeva, G., Voss, K., Heintzman, D.R., Xu, X., Madden, M.Z., Ye, X., Beier, K.L., Chowdhury, N.U., Wolf, M.M., et al. (2022). MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 55, 65-81.e9.
Coaches: Alexis Combes, PhD & Joanna Halkias, MD