Alexander Marson, MD, PhD

Assistant Professor
Department of Microbiology and Immunology
Alexander.Marson@ucsf.edu

Our group employs an integrative genomics approach to decode the genetic programs governing CD4+ T-cell sub-specialization. We study the molecular circuitry that governs differentiation of pro-inflammatory and regulatory T cells, and the ways in which mutations affecting this circuitry contribute to immune dysregulation in human disease. We aim to connect the transcriptional regulatory circuitry of T cells to human genetic studies and functional genomic screens to advance understanding of specialized CD4+ T-cell functions and potentially generate novel therapeutic strategies for immune-mediated diseases.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
Our group employs an integrative genomics approach to decode the genetic programs governing CD4+ T-cell sub-specialization.

Websites

Featured Publications: 

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

Proceedings of the National Academy of Sciences of the United States of America

Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Nature

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE

Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms.

Immunity

Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells.

Cell

Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA

Foxp3 occupancy and regulation of key target genes during T-cell stimulation.

Nature

Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, MacIsaac KD, Levine SS, Fraenkel E, von Boehmer H, Young RA