2022-23 Journal Club Schedule
Journal Club Chairs: Bruce Wang, MD and Tien Peng, MD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location:In person at N-225 on the Parnassus campus, with a livestream/Zoom option as well. The Zoom link will be sent out with the email reminder sent to the BMS listservs. Please contact Demian Sainz if you are not already on one of our listservs.
Links to previous livestreams and recorded video are in the sidebar.
See the BMS Journal Club Archives in the right sidebar for past journal club descriptions and recordings.
September 7, 2023
Peter Bruno (faculty)
"Vaccine-boosting improves CAR-T therapy and host immune response"
L. Ma, et al., Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity. Cell 186, 3148-3165.e20 (2023).
Isabelle Young (student)
"Scribble mis-localization induces adaptive resistance to KRASG12C inhibitors"
Adachi Y, Kimura R, Hirade K, et al. Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS. Nat Cancer. 2023;4(6):829-843. doi:10.1038/s43018-023-00575-2
Coaches: Jonathan Ostrem, MD, PhD & Michael Waterfield, MD, PhD
September 14, 2023
Max Pass (student)
Meiser, P. et al. A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. Cancer Cell 0, (2023).
Coaches: Matt Spitzer, PhD & Max Krummel, PhD
September 21, 2023
Roarke Kamber (faculty)
"Fuse and conquer: how giant macrophages protect the diseased liver"
Peiseler, M., Araujo David, et al., 2023. Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver. Science, 381(6662), p.eabq5202.
Tori Tran (student)
"Context clues: Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation"
Pirillo C, Al Khalidi S, Sims A, Devlin R, Zhao H, Pinto R, Jasim S, Shearer PA, Shergold AL, Donnelly H, Bravo-Blas A, Loney C, Perona-Wright G, Hutchinson E, Roberts EW. Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Sci Immunol. 2023 Jul 21;8(85):eadg8249. doi: 10.1126/sciimmunol.adg8249. Epub 2023 Jul 21. PMID: 37478193.
Coaches: Tiffany Scharschmidt, MD & Ari Molofsky, MD, PhD
September 28, 2023
Elliott Sherr (faculty)
"Perhaps the first across the finish line"
Neul JL, et al. Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study. Nat Med. 2023 Jun;29(6):1468-1475. doi: 10.1038/s41591-023-02398-1. Epub 2023 Jun 8.PMID: 37291210
Isabel Shen (student)
"It seems anything can be put in an array now."
Ortiz-Muñoz, G., Brown, M., Carbone, C.B. et al. In situ tumour arrays reveal early environmental control of cancer immunity. Nature 618, 827–833 (2023). https://doi.org/10.1038/s41586-023-06132-2
Coaches: Gabi Fragiadakis, PhD & Oscar Aguilar Alfaro, PhD
October 5, 2023
Mingyang Ma (student)
"How an anxious heart talks to the brain"
Hsueh, B., Chen, R., Jo, Y. et al. Cardiogenic control of affective behavioural state. Nature 615, 292–299 (2023). https://doi.org/10.1038/s41586-023-05748-8
Coaches: Ritchie Chen, PhD, MSc, BS & Guo Huang, PhD
October 12, 2023
Sara Suliman (faculty)
"Direct and indirect sensing of infection, the case of MAIT cells"
López-Rodríguez JC, et al. Type I interferons drive MAIT cell functions against bacterial pneumonia. J Exp Med. 2023 Oct 2;220(10):e20230037. doi: 10.1084/jem.20230037. Epub 2023 Jul 26. PMID: 37516912; PMCID: PMC10373297.
Madison Lotstein (student)
"Smoothing Things Over With MaxFuse"
Chen, S., Zhu, B., Huang, S. et al. Integration of spatial and single-cell data across modalities with weakly linked features. Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-01935-0
Coaches: Gabi Fragiadakis, PhD & Alexis Combes, PhD
October 19, 2023
Michael Alexanian (faculty)
"New Frontiers in Epigenomics: Chromatin Remodeling in Alzheimer’s disease"
Xiong, James, Boix at al., Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion.
Cell. 2023 Sep 28;186(20):4422-4437.e21. doi: 10.1016/j.cell.2023.08.040
Gary Chan (student)
"Gotta Target 'Em All: Reprogram myeloid cells in glioblastoma via KDM6B inhibition"
Goswami, S., Raychaudhuri, D., Singh, P. et al. Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nat Cancer (2023). https://doi.org/10.1038/s43018-023-00620-0
Coaches: Joe Costello, PhD & Hideho Okada, MD, PhD
October 26, 2023
Rukman Thota (student)
"James Bonds favorite tumor model"
Chen, D. et al. CTLA-4 blockade induces CD4+ T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. Immunity 56, 2086-2104.e8 (2023).
Coaches: Alexis Combes, PhD & Andrew Yang, PhD
November 2, 2023
Isha Jain (faculty)
"Beyond Oxygen Transport: Haemoglobin's Extraordinary Role in Chondrocytes"
Zhang, F., Zhang, B., Wang, Y., Jiang, R., Liu, J., Wei, Y., Gao, X., Zhu, Y., Wang, X., Sun, M. and Kang, J., 2023. An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption. Nature, pp.1-8.
Zachary Stensland (student)
"I can't come into work today, my ferret gave me bird flu"
Sun H, Li H, Tong Q, Han Q, Liu J, Yu H, Song H, Qi J, Li J, Yang J, Lan R, Deng G, Chang H, Qu Y, Pu J, Sun Y, Lan Y, Wang D, Shi Y, Liu WJ, Chang KC, Gao GF, Liu J. Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets. Cell. 2023 Sep 14;186(19):4074-4084.e11. doi: 10.1016/j.cell.2023.08.011. Epub 2023 Sep 4. PMID: 37669665.
Coaches: Angela Phillips, PhD & Alexis Combes, PhD
November 9, 2023
Elphege Nora (faculty)
"Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus"
Gjaltema et al., Molecular Cell https://www.sciencedirect.com/science/article/pii/S109727652101025X?via%3Dihub
Jing-Yi Chung (student)
"A new macrophage polarity called “CS” "
Bill, R. et al., CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science 381,515-524(2023). DOI:10.1126/science.ade2292
Coaches: Matt Spitzer, PhD & Roarke Kamber, PhD
November 16, 2023
Khang Nguyen (student)
"The Last of the TME (TumorMycoEnvironment)"
Liu, Ning-Ning et al. “The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells.” Cancer cell, S1535-6108(23)00288-X. 19 Sep. 2023, doi:10.1016/j.ccell.2023.08.012
Coaches: Jeroen Roose, PhD & Mary Helen Barcellos-Hoff, PhD
November 30, 2023
David Solomon (faculty)
"Unraveling the causes and consequences of aneuploidy in cancer"
Girish V, Lakhani AA, Thompson SL, Scaduto CM, Brown LM, Hagenson RA, Sausville EL, Mendelson BE, Kandikuppa PK, Lukow DA, Yuan ML, Stevens EC, Lee SN, Schukken KM, Akalu SM, Vasudevan A, Zou C, Salovska B, Li W, Smith JC, Taylor AM, Martienssen RA, Liu Y, Sun R, Sheltzer JM. Oncogene-like addiction to aneuploidy in human cancers. Science. 2023 Aug 25;381(6660):eadg4521. PMID: 37410869. https://pubmed.ncbi.nlm.nih.gov/37410869/
McKenzie Daanen (student)
"Shift Happens"
van de Sandt, C.E., Nguyen, T.H.O., Gherardin, N.A. et al. Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan. Nat Immunol 24, 1890–1907 (2023). https://doi.org/10.1038/s41590-023-01633-8
Coaches: Matt Spitzer, PhD & Oscar Aguilar Alfaro, PhD
December 7, 2023
Jayden Ross (student)
"CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice"
Sun, S., Meng, Y., Li, M. et al. CD133+ endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice. Nat Aging 3, 1401–1414 (2023). https://doi.org/10.1038/s43587-023-00512-z
Coaches: Betsy Crouch, MD, PhD & Ethan Winkler, MD, PhD
December 14, 2023
David Raleigh (faculty)
"Two wrongs apparently make one wrong a little less wrong."
Ling, A.L., Solomon, I.H., Landivar, A.M. et al. Clinical trial links oncolytic immunoactivation to survival in glioblastoma. Nature 623, 157–166 (2023). https://doi.org/10.1038/s41586-023-06623-2
Max Pass (student)
“The one that didn’t get away: a distinct intratumoral population of cDC1s that amplify CD8 T cell responses"
Meiser, P. et al. A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity. Cancer Cell 0, (2023).
Coaches: Matt Spitzer, PhD & Max Krummel, PhD
January 11, 2024
Maddie Urbanek (student)
"Getting Groovy with Epi-Retro-seq"
Zhou, J., Zhang, Z., Wu, M. et al. Brain-wide correspondence of neuronal epigenomics and distant projections. Nature 624, 355–365 (2023). https://doi.org/10.1038/s41586-023-06823-w
Coaches: Betsy Crouch, MD, PhD & Cathryn Cadwell, MD, PhD
Sara Misiukiewicz (student)
"UndersTANding TANs: The local microenvironment drives activation of neutrophils in human brain tumors."
Maas RR, et al. The local microenvironment drives activation of neutrophils in human brain tumors. Cell. 2023 Oct 12;186(21):4546-4566.e27. doi: 10.1016/j.cell.2023.08.043. Epub 2023 Sep 27. PMID: 37769657.
Coaches: Roarke Kamber, PhD & Matt Spitzer, PhD
January 18, 2024
Julia McBride (student)
"An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis"
LaMarche, N.M., Hegde, S., Park, M.D., Maier, B.B., Troncoso, L., Le Berichel, J., Hamon, P., Belabed, M., Mattiuz, R., Hennequin, C., et al. (2023). An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature, 1–9. 10.1038/s41586-023-06797-9.
Coaches: Alejandro Sweet-Cordero, MD & TBD
Celeste Garza (student)
"Sensory neurons promote immune homeostasis in the lung"
Masato Tamari et al. Sensory neurons promote immune homeostasis in the lung. Cell. 2024, Pages 44-61.e17, SSN 0092-8674, https://doi.org/10.1016/j.cell.2023.11.027.
Coaches: Roberto Ricardo-Gonzalez, MD, PhD & Marlys Fassett, MD, PhD
January 25, 2024
Madeline McCanne (student)
"Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing"
Mishra, A. K. et al. Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M-mediated cancer cell killing. Proceedings of the National Academy of Sciences 120, e2310221120 (2023).
Coaches: Jason Cyster, PhD & Max Krummel, PhD
Sangeetha Ramachandran (student)
"Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer"
Ayuso, J.M., Farooqui, M., Virumbrales-Muñoz, M. et al. Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer. Nat Commun 14, 6681 (2023). https://doi.org/10.1038/s41467-023-41625-8
Coaches: Oscar Aguilar, PhD & Catera Wilder, PhD
February 1, 2024
Jaela Caston (student)
"Unveiling the influences of neural crest derived cells on T cell maturity"
Naoki Tsunokuma, Doris Narki Tetteh, Kana Isono, Mari Kuniishi-Hikosaka, Motokazu Tsuneto, Kenichiro Ishii, Hidetoshi Yamazaki; Depletion of Neural Crest–Derived Cells Leads to Plasma Noradrenaline Decrease and Alters T Cell Development. J Immunol 15 November 2023; 211 (10): 1494–1505.
https://doi.org/10.4049/jimmunol.2300045
Coaches: Max Krummel, PhD & Paola Betancur, PhD
Jim Asaki (student)
"TScan II: Reloaded"
Dezfulian, M. H. et al. TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell. 2023 Dec 7;186(25):5569-5586.e21. doi: 10.1016/j.cell.2023.10.024. Epub 2023 Nov 27. PMID: 38016469
Coaches: Peter Bruno, PhD & Rachel Rutishauser, MD, PhD
February 8, 2024
Gabriella Kimmerly (student)
"Epitope editing mitigates on-target/off tumor effects of a universal blood cancer CAR T cell therapy"
Wellhausen N, et al. Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy. Sci Transl Med. 2023 Sep 20;15(714):eadi1145. doi: 10.1126/scitranslmed.adi1145. Epub 2023 Sep 20. PMID: 37651540; PMCID: PMC10682510.
Coaches: Justin Eyquem, PhD, MS & Oscar Aguilar, PhD
Sophia Nelson (student)
TBD
Hyunjung Min, Shane M. O’Neil, Li Xu, E. Ashley Moseman, Joanne Kurtzberg, Anthony J. Filiano; Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance. J Exp Med 5 February 2024; 221 (2): e20230326. doi: https://doi.org/10.1084/jem.20230326
Coaches: Betsy Crouch, MD, PhD & Andrew Yang, PhD
February 15, 2024
Sarah Castro (student)
“Save room for de(ssert) mushrooms: how fungi trigger an anti-tumor response”
Max M. Wattenberg et al. Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1.Sci. Immunol.8,eadj5097(2023).DOI:10.1126/sciimmunol.adj5097
Coaches: Oliva Lu, PhD & Karin Pelka, PhD
Ivan Chavez (student)
"Damsels in Drag: The evolutionary genomics of intersexual mimicry in damselflies"
Willink, B., Tunström, K., Nilén, S. et al. The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies. Nat Ecol Evol 8, 83–97 (2024). https://doi.org/10.1038/s41559-023-02243-1
Coaches: David Booth, PhD & TBD
February 22, 2024
Minna Apostolova (student)
"The (T cell) Mandela Effect: Flexibility in T cell Memory Formation"
Abadie, Kathleen et al. “Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.” Immunity, S1074-7613(23)00537-X. 29 Jan. 2024, doi:10.1016/j.immuni.2023.12.006
Coaches: Matt Spitzer, PhD & Rachel Rutishauser, MD, PhD
Manon Miller (student)
"Interferon-ε is a tumor suppressor and restricts ovarian cancer"
Marks, Z.R.C., Campbell, N.K., Mangan, N.E. et al. Interferon-ε is a tumour suppressor and restricts ovarian cancer. Nature 620, 1063–1070 (2023). https://doi.org/10.1038/s41586-023-06421-w
Coaches: Katherine Fuh, MD, PhD & Alexis Combes, PhD
February 29, 2024
Clara Kochendoerfer (student)
"Two targets is better than one: a bispecific CAR T cell therapy for multiple myeloma"
Sun, F., et al. (2024). Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. Nature communications, 15(1), 615. https://doi.org/10.1038/s41467-024-44873-4
Coaches: Justin Eyquem, PhD, MS, BS & Greg Allen, MD, PhD
March 7, 2024
Ankit Salhotra (student)
“CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus”
Badr, M. E., Zhang, Z., Tai, X., & Singer, A. (2023). CD8 T cell tolerance results from eviction of immature autoreactive cells from the thymus. Science, 382(6670), 534–541. https://doi.org/10.1126/science.adh4124
Coaches: Peter Bruno, PhD & Mark Anderson, MD, PhD
Claire Havig (student)
"Memories in the Making: Tracing the CD27-TRAF2-SHP-1 Pathway in Memory T cell Differentiation”
Jaeger-Ruckstuhl CA, Lo Y, Fulton E, Waltner OG, Shabaneh TB, Simon S, et al. Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks. Immunity. 2024;57(2):287-302.e12. doi: 10.1016/j.immuni.2024.01.011.
Coaches: Tiffany Scharschmidt, MD & Julia Carnevale, MD
March 14, 2024
Rachel Prorok (student)
“A Brainy Tale of Gene-ius Monitoring”
Lee, S., Nouraein, S., Kwon, J.J. et al. Engineered serum markers for non-invasive monitoring of gene expression in the brain. Nat Biotechnol (2024).
Coaches: Betsy Crouch, MD, PhD and David Solomon, MD, PhD
Nikhita Kirthivasan (student)
"GlycoRNAs on the Catwalk: Neutrophils Strutting their way to Inflammation"
Zhang N, et al. Cell surface RNAs control neutrophil recruitment. Cell. 2024 Feb 15;187(4):846-860.e17. doi: 10.1016/j.cell.2023.12.033. Epub 2024 Jan 22. PMID: 38262409
Coaches: Jason Cyster, PhD and Clifford Lowell, MD, PhD
March 21, 2024
Vickie Bowcut (student)
"Amino Alchemy: Crafting New G-Protein Activation States"
Hewitt N, Ma N, Arang N, et al. Catalytic site mutations confer multiple states of G protein activation. Sci Signal. 2023;16(772):eabq7842. doi:10.1126/scisignal.abq7842
Coaches: Frank McCormick, PhD, FRS & Jon Ostrem, MD, PhD
Serena Lu (student)
"Breaking the Code: Neuronal DNA Double-Strand Breaks and Neurodegeneration"
Dileep, V., et al (2023). Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell, 186(20), 4404–4421.e20. https://doi.org/10.1016/j.cell.2023.08.038
Coaches: Dan Lim, MD, PhD & Abby Buchwalter, PhD
March 28, 2024
Riana Hunter (student)
“Decidual T cells protect against CMV at the maternal-fetal interface”
Decidual-tissue-resident memory T cells protect against nonprimary human cytomegalovirus infection at the maternal-fetal interface
Or Alfi…, Dana G. Wolf, et al. Cell Reports (2024). https://www.cell.com/cell-reports/pdf/S2211-1247(24)00026-3.pdf
Coaches: Maggie Feeney, MD & Mary Prahl, MD
Mingyang Ma (student)
"Sleep's Tiny Guardians: Unveiling How Microglia Tune Our Slumber"
Ma, Chenyan, et al. "Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission." Nature Neuroscience (2024): 1-10.
Coaches: Ying-Hui Fu, PhD & Louis Ptacek, MD
April 4, 2024
Andrew Pan (student)
"Metalloproteases might make you moody: a link between the peripheral immune system and depression"
Cathomas, F., Lin, HY., Chan, K.L. et al. Circulating myeloid-derived MMP8 in stress susceptibility and depression. Nature 626, 1108–1115 (2024). https://doi.org/10.1038/s41586-023-07015-2
Coaches: Tom Nowakowski, PhD & Andrew Yang, PhD
Courtney Tamaki (student)
"Deterministic reprogramming of neutrophils within tumors"
Ng, M. S. F., et al. (2024). Deterministic reprogramming of neutrophils within tumors. Science (New York, N.Y.), 383(6679), eadf6493. https://doi.org/10.1126/science.adf6493
Coaches: Clifford Lowell, MD, PhD & Matthew Stachler, MD, PhD
April 11, 2024
Lily Zemelko (student)
“HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity”
Stephen A. Migueles et al., HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity. Science 382, 1270-1276(2023). DOI:10.1126/science.adg0514.
Coaches: Rachel Rutishauser, MD, PhD & Joel Ernst, MD
Tasha Tsao (student)
"KIRs & Heartache: NK cells and acute myocarditis post-COVID vaccination"
Tsang HW, et al. The central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination. Med. 2024 Mar 15:S2666-6340(24)00080-1. doi: 10.1016/j.medj.2024.02.008. Epub ahead of print. PMID: 38521068.
Coaches: Oscar Aguilar, PhD & Timothy Henrich, MD
April 18, 2024
Jose Gomez (student)
"The Toll to Remember"
Jovasevic, Vladimir, et al. “Formation of Memory Assemblies through the DNA-Sensing TLR9 Pathway.” Nature News, Nature Publishing Group, 27 Mar. 2024, www.nature.com/articles/s41586-024-07220-7.
Coaches: Richard Locksley, MD& Tomasz Nowakowski, PhD
Kira Downey (student)
"Lessons in Immune Cell Match-Making: Building a Bispecific Dendritic Cell – T-Cell Engager to Remodel the Tumor Immune Landscape"
Itai et al. "Bispecific dendritic-T cell engager potentiates anti-tumor immunity" Cell 2024
Coaches: Greg Allen, MD, PhD & Kole Roybal, PhD
April 25, 2024
Charles Shen (student)
"Bone marrow plasma cells require P2RX4 to sense extracellular ATP"
Ishikawa, M., Hasanali, Z.S., Zhao, Y. et al. Bone marrow plasma cells require P2RX4 to sense extracellular ATP. Nature 626, 1102–1107 (2024). https://doi.org/10.1038/s41586-024-07047-2
Coaches: Jason Cyster, PhD & Oscar Aguilar, PhD
Trishna Patel (student)
"A Cancer-Fighting Dynamic Duo: Targeted Therapies and Macrophages Unite Against NSCLC"
Vaccaro K, et al. Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction. J Clin Invest. 2024 Mar 14:e169315. doi: 10.1172/JCI169315. Epub ahead of print. PMID: 38483480.
Coaches: Roarke Kamber, PhD & Paola Betancur, PhD
May 2, 2024
Karla DeLucas (student)
TBD
Renee R. Anderko et. al Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy. J Immunol 2024; ji2300672. https://doi.org/10.4049/jimmunol.2300672.
Coaches: Oscar Aguilar, PhD & Rachel Rutishauser, MD, PhD
Rebecca Chu (student)
TBD
Ross, J.B., Myers, L.M., Noh, J.J. et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature (2024). https://doi.org/10.1038/s41586-024-07238-x
Coaches: Serine Avagyan, MD, PhD & Cliff Lowell, MD, PhD
May 9, 2024
Harnoor Virk (student)
TBD
Chelko SP, Penna VR, Engel M, et al. NFĸB signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy. J Clin Invest. April 2, 2024. doi:10.1172/JCI172014
Coaches: Alexis Combes, PhD & Michael Alexanian, PhD
Mackenzie Roberts (student)
TBD
Coaches: Dena Dubal, MD, PhD & Diana Laird, PhD
May 16, 2024
Lauren Tabor (student)
TBD
Wu, Yingcheng, et al. “Neutrophil profiling illuminates anti-tumor antigen-presenting potency.” Cell, vol. 187, no. 6, Mar. 2024, https://doi.org/10.1016/j.cell.2024.02.005
Coaches: Peter Bruno, PhD & Matthew Krummel, PhD
Joy Okoro (student)
TBD
May 23, 2024
Cassie Martinez (student)
TBD
Cappelluti, M. A., Mollica Poeta, V., Valsoni, S., Quarato, P., Merlin, S., Merelli, I., & Lombardo, A. (2024). Durable and efficient gene silencing in vivo by hit-and-run epigenome editing. Nature, 627(8003), 416–423. https://doi.org/10.1038/s41586-024-07087-8
Coaches: TBD
Zachary Holmes (student)
TBD
Chen, X., Luo, Y., Zhu, Q. et al. Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism. Nat Aging (2024). https://doi.org/10.1038/s43587-024-00612-4
Coaches: Saul Villeda, PhD & Roarke Kamber, PhD
May 30, 2024
Eva Gillis-Buck (student)
TBD
Jerry Wang (student)
TBD
Coaches: Ethan Winkler, MD, PhD & Betsy Crouch, MD, PhD