BMS Journal Club 2017-18 (Fall 2017)

BMS Journal Club presentations are available via livestream and recorded video. You can access them via the links below. UCSF MyAccess login is required.

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September 7, 2017

Saul Villeda, PhD (Faculty)
"High as a Kite: Making the Old Brain Young Again?"
Bilkei-Gorzo, Andras et al. "A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice." Nature Medicine 23, 782–787 (2017).​

Alexis Krup (Student)
“The Crypt Keepers: a story of secret stem cells, as told by their chromatin”
Jadhav, Unmesh et al. “Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.” Cell Stem Cell 21.1 (2016): 65–77.e5.
Coaches: Miguel Ramalho-Santos and Robert Blelloch

September 14, 2017

Joseph Shieh, MD, PhD (Faculty)
"Are we heterogeneous or homogeneous? Natural variation, mutation, and disease"
Florian Zink et al. "Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly." Blood , no. (2017): blood-2017-02-769869.​

Patrick Schupp (Student)
A Glioma miR-acle: miR128 drives Class Shift in Glioblastoma Stem-like Cells
Rooj, A. K. et al. MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 19, 2026–2032 (2017).
Coaches: Michael Oldham and Samuel Shelton

September 21, 2017

JJ Miranda, PhD (Faculty)
“Redefining viral infection during cancer”
Yogev O, Henderson S, Hayes MJ, Marelli SS, Ofir-Birin Y, Regev-Rudzki N, et al. (2017) Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs. PLoS Pathog 13(8): e1006524.

Jerika Barron (Student)
"Stop interferon’ with my synapses! IFN drives microglia-dependent synapse loss in CNS lupus"
Bialas, A. R. et al. Microglia-dependent synapse loss in type I interferon-mediated lupus. Nature 546, 539–543 (2017).
Coaches: Anna Molofsky and Susanna Rosi

September 28, 2017

Aaron Tward, MD, PhD (Faculty)
"The DRIVE to find Achilles’ heels of cancer: shRNA works great … if you have 100,000 of them."
Tsherniak A. et al. "Defining a Cancer Dependency Map." Cell, 170(3):564-576.e16. 2017.
McDonald E.R. et al. "Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening." Cell 170(3):577-592.e10. 2017.

Johnny Yu (student)
"Hi, my name is Cancer and I'm an exosome-oholic."
Nabet, B.Y. et al. "Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer." Cell, Volume 170 (2), 352-366. 2017.
Coaches: Hani Goodarzi and Luke Gilbert

October 5, 2017

Laura van 't Veer, PhD (Faculty)
"Chemotherapy indices metastasis, ‘of mice to (wo-)men"
Karagiannis, George et al. “Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism.” Science Translation Medicine 05 Jul 2017: Vol. 9, Issue 397

Geil Merana (student)
"New Cell on the Block"
Wang S. et al. "Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation." Cell 171 (1), 201-216. 2017 Aug 24.
Coaches: Tiffany Scharschmidt and Ari Molofsky

October 12, 2017

Raymond Swanson, MD (Faculty)
"Et tu, dopamine?"
Mor, D.E. et al. "Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration." Nature Neuroscience (2017).

Katerina Popova (Student)
"Don't get antsy...CRISPR-engineered ants are already here!"
Hua, Y. et al. An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants. Cell 170(4), 736-747, 10 Aug 2017.
Coaches: Stephen Floor and Luke Gilbert

October 19, 2017

Arun Wiita, MD, PhD (Faculty)
"It's ok to judge a tumor by its cover"
Bosse KR et al. Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer Cell (2017) 32:295.​

Anthony Venida (Student)
"The Sidekick Tale of an Immune Checkpoint Regulator: CMTM6 is to PD-L1 as Robin is to Batman"
Burr, Marian L. et al. "CMTM6 Maintains the Expression of PD-LI and Regulates Anti-Tumor Immunity." Nature 549, 101-105 (2017).
Coaches: Rushika Perera and Matthew Spitzer

October 26, 2017

Aditi Bhargava, PhD (Faculty)
"Sex or Gender: Scoop on COUP-TFII"
Zhao, F. et al. "Elimination of the male reproductive tract in the femal embryo is promoted by COUP-TFII in mice." Science, 357, 6352, 717-720. 18 Aug 2017.​

Karen Wong (Student)
"Most wanted: missing sequences in the reference genome"
Kehr B. et al. “Diversity in non-repetitive human sequences not found in the reference genome.” Nature genetics. 49, 588-593. 2017 Feb 27.
Coaches: Joseph Shieh and Marina Sirota

November 2, 2017

Seemay Chou, PhD (Faculty)
"Controlled destruction: how predatory microbes navigate prey cells"
Kuru, E. et al. Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature Microbiology doi:10.1038/s41564-017-0029-y. epub 3 Oct 2017.

Jeremy Williams (Student)
"Don't take the STING out of treatment: How the cGAS pathway can drive abscopal response to cancer therapy."
Harding, S. M., Benci, J. L., Irianto, J., Discher, D. E., Minn, A. J., & Greenberg, R. A. (2017). Mitotic progression following DNA damage enables pattern recognition within micronuclei. Nature Publishing Group, 548(7668), 466–470.
Coaches: Stephen Floor and Andrei Goga

November 9, 2017

Stephen Floor, PhD (Faculty)
Title: "To PB or not to PB: Condensed Granules of RNA Regulons"
Hubstenberger, A. et al. "P-Body Purification Reveals the Condensation of Repressed mRNA Regulons" Molecular Cell 68, 1-14 (2017).

Elma Frias (Student)
"Hungry Hungry Astrocytes"
Morizawa, Yosuke M. et al. “Reactive Astrocytes Function as Phagocytes after Brain Ischemia via ABCA1-Mediated Pathway.” Nature Communications 8 (2017): 28.
Coaches: Susanna Rosi and TBA

November 16, 2017

Rushika Perera, PhD (Faculty)
"Quality over quantity wins!"
Balachandran, V.P. et al. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature, doi:10.1038/nature24462. epub Nov 8, 2017.​

Nicholas Gentry (Student)
"A further step in uncovering the molecular basis of memory"
Mews, P. et al. Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature 546, 381-386. (2017).
Coaches: Bassem Al-Sady and Daniel Lim

November 30, 2017

Andy Chang, PhD (Faculty)
"Who needs oxygen when you have fructose"
Park, TJ. et al. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science. 2017 Apr 21;356(6335):307-311.​

Jeanmarie Gonzalez (Student)
"Bad intestines: oral bacteria driving inflammation in the gut"
Atarashi, K. et al. Ectopic colonization of oral bacteria in the intestine drives Th1 cell induction and inflammation. Science. 358, 6361, 359-365. 20 October 2017.
Coaches: Tiffany Scharschmidt and Peter Turnbaugh

December 7, 2017

Diana Laird, PhD (Faculty)
"When sex is negative and cancer is positive"
Martincorena, I. et al. Universal Patters of Selection in Cancer and Somatic Tissues. Cell 171, 1029-1041. (2017).

Didi Zhu (Student)
Turn Up for What? ILC2s Turn Up for Neuromedin U
Cardoso V. et al. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature 549: 277-281 (2017).
Coaches: Ari Molofsky and Mark Ansel