
Assistant Investigator
Primary Thematic Area
M_Neurology
Secondary Thematic Area
Research Summary
We develop new approaches to decipher communication between the brain and immune system. We study what these messages mean, how they’re regulated, and how they impact brain health.
Our lab studies the molecular logic of crosstalk between the brain and body. We develop new approaches to decode the meaning, mechanisms, and therapeutic relevance of unexpected protein and immune cell communication across brain barriers. By deciphering the general principles by which the periphery communicates with the brain, we will understand and rationally modulate key intercellular pathways to confer greater resilience against brain aging and neurodegeneration.
Publications
Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling.
Stem cell reviews and reports
Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics.
American journal of human genetics
CD4+ T cells contribute to neurodegeneration in Lewy body dementia.
Science (New York, N.Y.)
Cell type-selective secretome profiling in vivo.
Nature chemical biology
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.
Nature medicine
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics.
Journal of the American Chemical Society