Marco Conti

Professor & CRS Director
Department of Obstetrics Gynecology & Reproductive Sciences
Center for Reproductive Sciences
contim@obgyn.ucsf.edu

Dr. Conti's research focuses on signal transduction required for germ cell development. Over the past 15 years, we have charted signaling pathways controlling oocyte meiotic maturation and competence for development into an embryo. We have identified critical signals arising in the somatic cells at the time of ovulation that are required to establish oocyte developmental competence. Genetic models that disrupt these pathways and compromise developmental competence and early embryo development have been established.

Focus of the experiments is on understanding how disruption of developmental competence in these genetic models is reflected in the pattern of recruitment of maternal mRNA translation into proteins critical for nuclear reprogramming and early embryo development. This strategy has the potential to identify components critical for the epigenetic regulations required for early embryo development. The impact of this research program on stem cell research is twofold. These studies are relevant to the understanding of the mechanisms controlling cell replication and nuclear reprogramming during preimplantation embryo development and lineage specification.

A better understanding of the biochemical mechanisms controlling oocyte maturation is essential for successful development of embryonic stem cells into artificial gametes. In addition, they will provide insights into mechanisms necessary for successful somatic nuclear transfer critical to the derivation of hESC for therapeutic use.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
None
Research Summary: 
Mechanisms of Action of Peptide Hormones and Growth Factors
Publications: 

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.

The Journal of cell biology

Zhang QH, Yuen WS, Adhikari D, Flegg JA, FitzHarris G, Conti M, Sicinski P, Nabti I, Marangos P, Carroll J

Maternal mRNAs with distinct 3' UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation.

Genes & development

Yang Y, Yang CR, Han SJ, Daldello EM, Cho A, Martins JPS, Xia G, Conti M

Functional selectivity of GPCR-directed drug action through location bias.

Nature chemical biology

Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M

Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells.

Proceedings of the National Academy of Sciences of the United States of America

Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M