Elad Ziv, MD

Professor
Department of Medicine
+1 415 514-4930

Our group is focused on identifying genetic factors that underlie complex traits in humans. We use an approach that combines principles from population genetics and epidemiology. A major aim of our group is understanding susceptibility to cancer and response to cancer treatment.

Current projects include:

  1. Genetics of Breast Cancer in Latina women:  We are using both genome wide association (GWAS) and next generation sequencing (NGS) to identify loci and genes associated with breast cancer in this population.
  2. Genetics of Mammographic Density: Identification of genes and genetic variants associated with mammographic density.  Mammographic density is a strong risk factor for breast cancer and twin studies suggest it is highly heritable. We are using a combination of GWAS, identity by descent mapping and NGS to search for genes associated with this trait.
  3. Genetic analysis of Multiple Myeloma. We are using a GWAS approach to investigate how germline genetic variants affect susceptibility to, complications from and prognosis among patients with myeloma.

We are also interested in pharmacogenetics of cancer treatment. In the past, we have done work on genetic analysis of benign ethnic neutropenia, serum inflammatory markers and on the genetic contribution to human longevity.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Application of Population Genetics to the Study of Complex Traits in Humans

Websites

Featured Publications: 

Corrigendum: Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.

Nature communications

Ziv E, Dean E, Hu D, Martino A, Serie D, Curtin K, Campa D, Aftab B, Bracci P, Buda G, Zhao Y, Caswell-Jin J, Diasio R, Dumontet C, Dudzinski M, Fejerman L, Greenberg A, Huntsman S, Jamroziak K, Jurczyszyn A, Kumar S, Atanackovic D, Glenn M, Cannon-Albright LA, Jones B, Lee A, Marques H, Martin T, Martinez-Lopez J, Rajkumar V, Sainz J, Juul Vangsted A, Watek M, Wolf J, Slager S, Camp NJ, Canzian F, Vachon C

Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.

Nature communications

Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, Tsung K, John EM, Torres-Mejia G, Carvajal-Carmona L, Echeverry MM, Tuazon AM, Ramirez C

Genetic ancestry and risk of mortality among U.S. Latinas with breast cancer.

Cancer research

Fejerman L, Hu D, Huntsman S, John EM, Stern MC, Haiman CA, Pérez-Stable EJ, Ziv E