Daniel Bikle, MD, PhD

Professor
Department of Medicine
Department of Dermatology
+1 415 575-0557

My research is focused on the hormonal regulation of calcium metabolism, and includes projects involving the classic target tissue of bone as well as non classic tissues such as the skin. The projects  with bone focus on the mechanisms by which parathyroid hormone and insulin like growth factor-1 regulate bone formation and differentiation, the response of bone to mechanical loading and unloading, and the ability of bone to heal fractures. We use a number of cell specific gene deletion models in different cells in the skeleton to address these questions. The projects in skin examine the mechanisms by which calcium and 1,25(OH)2D regulate keratinocyte differentiation, wounding repair, and skin cancer development. We are focusing on the calcium and vitamin D receptors, and the signaling pathways and transcriptional events mediated by their activation and keratinocyte specific deletion.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of cellular differentiation and function by calciotropic hormones

Websites

Publications: 

Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.

The Journal of biological chemistry

Yoshizaki K, Hu L, Nguyen T, Sakai K, Ishikawa M, Takahashi I, Fukumoto S, DenBesten PK, Bikle DD, Oda Y, Yamada Y

Current Assays to Determine Free 25-Hydroxyvitamin D in Serum.

Journal of AOAC International

Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD

VITAMIN D BINDING PROTEIN AND 25-HYDROXYVITAMIN D LEVELS: EMERGING CLINICAL APPLICATIONS.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Jassil NK, Sharma A, Bikle D, Wang X

Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?

The Journal of steroid biochemistry and molecular biology

Bikle D, Bouillon R, Thadhani R, Schoenmakers I