Carol Gross, PhD

Professor
Department of Cell & Tissue Biology
+1 415 476-4161

My overall interest is to study global regulatory networks in the bacterium E. coli, an organism that is amenable to genetic and biochemical approaches. We study two different problems, each of which illuminates this issue from different perspectives. Our study of the heat shock response has led us into a consideration of how the cell monitors and regulates the folding state of proteins, how proteins are targeted for degradation and how the cytoplasmic and periplasmic compartments in E. coli are coordinated. Our study of transcriptional regulatory networks has led us to dissect the functional anatomy of RNA polymerase and to establish a genomics approach to discover the connections between different networks.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Regulation of Gene Expression

Websites

Publications: 

Ribosomal Architecture: Constraints Imposed by the Need for Self-Production.

Current biology : CB

Hussmann JA, Osadnik H, Gross CA

Global analysis of translation termination in E. coli.

PLoS genetics

Baggett NE, Zhang Y, Gross CA

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis.

Cell systems

Koo BM, Kritikos G, Farelli JD, Todor H, Tong K, Kimsey H, Wapinski I, Galardini M, Cabal A, Peters JM, Hachmann AB, Rudner DZ, Allen KN, Typas A, Gross CA

Operon mRNAs are organized into ORF-centric structures that predict translation efficiency.

eLife

Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman JS, Gross CA

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.

Cell

Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS