BMS Journal Club
September 4, 2014-June 11, 2015
Journal Club Chairs: Mike German, MD and Suzanne Noble, MD, PhD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Live stream & archive: Spring 2015, Winter 2015, Fall 2014, Summer 2014 (9/4 and 9/11) (UCSF MyAccess login required)
September 04, 2014
Adrienne Stormo (student)
"Hunting for a Mechanism: Mutant Huntingtin Inhibits Mitochondrial Protein Import in Huntington's Disease"
Yano H, et al., Inhibition of mitochondrial protein import by mutant huntingtin. Nature Neuroscience 2014, 17:822–831.
Coaches: Ken Nakamura and Scott Oakes
Aimee Kao (faculty)
"A breath of fresh air before complete destruction: A new pathway for lysosomal clearance of misfolded proteins"
Satpute-Krishnan et al., ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway. Cell 2014, 158:522–533.
September 11, 2014
Melissa Spear (student)
"This Little Piggy: Defective mucus clearance is primary cause of lung disease in piglet model of cystic fibrosis"
Hoegger MJ, et al., Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science 2014, 345(6198):818-822.
Coaches: John Fahy and Jason Rock
Leor Weinberger (faculty)
"Fast and Efficient: HIV latency establishment in vivo"
Whitney JB et al., Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 2014, 512(7512):74-7.
September 18, 2014
Mission Bay videoconference: MH-1405
Tim Marsh (student)
"Myc's Side-Kicks: A Lnc to Tumorigenesis"
Tseng YY et al., PVT1 dependence in cancer with MYC copy-number increase. Nature Letters 2014, 512:82-86.
Coaches: Michael McManus and Jay Debnath
Guo Huang (faculty)
"Chasing Mysterious Adult Mammalian Cardiac Stem Cell"
van Berlo et al., c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature 2014, 509:337-341.
"Throwing the β-globin locus for a loop"
Deng W et al., Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 2014 Aug 14;158(4):849-60. doi: 10.1016/j.cell.2014.05.050.
Coaches: Alex Marson and Michael McManus
Bassem Al-Sady (faculty)
“How your grandkids know what you ate (or didn’t)”
Rechavi O et al., Starvation-induced transgenerational inheritance of small RNAs in C. elegans. Cell. 2014 Jul 17;158(2):277-87. doi: 10.1016/j.cell.2014.06.020.
October 02, 2014
Mission Bay videoconference: MH-1405
Christina Adams (student)
“Breaking up is hard to do: Cytokinesis failure leads to tetraploidy and Hippo pathway activation”
Ganem et al., Cytokinesis Failure Triggers Hippo
Tumor Suppressor Pathway Activation. Cell 2014, 158:833-848
Coaches: Scott Seeley and Andrei Goga
Raymond Swanson (faculty)
"Microglial stripping: a NOXious way to learn."
Zhang et al., Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase. Neuron 2014, 82:195-207.
October 9, 2014
Ibraheem Ali (student)
"A Small Stop to the Nonsense of Mutations."
Zhao et al., MicroRNA-mediated repression of nonsense mRNAs. eLife 2014;3:e03032. DOI: 10.7554/eLife.03032
Coaches: Mark Ansel and Michael McManus
Emin Maltepe (faculty)
"Livin' the High Life - Beef up that PHD."
Lorenzo FR et al., A genetic mechanism for Tibetan high-altitude adaptation. Nat. Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067.
October 16, 2014
Roman Camarda (student)
"If you bind it, allosteric regulation will come"
Sureka et al., The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell 2014, 158:1389–1401, http://dx.doi.org/10.1016/j.cell.2014.07.046
Coaches: Andrei Goga and Joanne Engel
Miguel Ramalho-Santos (faculty)
"Passive aggressive sex: 'Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote.'"
Guo et al., Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote. Cell Stem Cell. 2014 Oct 2;15(4):447-58. doi: 10.1016/j.stem.2014.08.003
October 23, 2014
Biao Wang (faculty)
“White fat browning is UP to stomach and brain.”
Ruan HB et al., O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell. 2014 Oct 9;159(2):306-17. doi: 10.1016/j.cell.2014.09.010.
David Erle (faculty)
"Sending a message: Promoters direct traffic during cell stress"
Zid BM and O’Shea EK. Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast. Nature 2014 Oct 2;514(7520):117-21. doi: 10.1038/nature13578.
October 30, 2014
Briana Fitch (student)
"Attack of the clones: Long-lived progenitor clones drive hematopoiesis."
Sun et al., Clonal dynamics of native haematopoiesis. Nature, 2014 Oct 5. doi:10.1038/nature13824
Coaches: Scott Kogan and Ann Zovein
Shaeri Mukherjee (faculty)
"Simple steps that lead to the removal of misfolded proteins from the ER."
Stein A et al., Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified Components. Cell. 2014 Sep 11;158(6):1375-88. doi: 10.1016/j.cell.2014.07.050.
November 06, 2014
Tommy Hennings (student)
"Foxy organ! Pancreatic β-cell function involves more than one FoxO factor."
Kim-Muller J et al. Metabolic Inflexibility Impairs Insulin Secretion and Results in MODY-like Diabetes in Triple FoxO-Deficient Mice. Cell Metabolism 2014 October 7; 20:593-602. http://dx.doi.org/10.1016/j.cmet.2014.08.012
Coaches: Julie Sneddon and Greg Ku
Jeoung-Sook Shin (faculty)
"TCR signaling fuels Treg cell suppressor function."
Levine et al., Continuous requirement for the TCR in regulatory T cell function. Nat Immunol. 2014 Sep 28. doi: 10.1038/ni.3004.
November 13, 2014
Jillian Jespersen (student)
"Opposing roles of two miRNAs: counter-regulation of follicular helper T cells during chronic inflammation."
Hu et al., miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014 Oct 16. doi:10.1016/j.immuni.2014.09.015
Coaches: Mehrdad Matloubian and Michael McManus
Paolo Rinaudo (faculty)
"Even the youngest ones have such an amazing memory!"
Rexhaj E et al., Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. J Clin Invest. 2013 Dec 2;123(12):5052-60. doi: 10.1172/JCI68943
November 20, 2014
Lindsey Jones (student)
"CRISPRing our way to novel murine models of cancer."
Xue W et al., CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 514:380-384, 2014 October 16. Doi:10.1038/nature13589
Coaches: Joe Costello and Andrei Goga
"Sister chromatids: Moving apart or together?"
Sarangapani KK et al. Sister kinetochores are mechanically fused during meiosis I in yeast. Science. 2014 Oct 10;346(6206):248-51. doi: 10.1126/science.1256729.
December 4, 2014
James Jung (student)
"Pulmonary macrophage transplantation therapy."
Suzuki, T., et al., Pulmonary macrophage transplantation therapy. Nature 2014, October 23. 514:450-454. doi:10.1038/nature13807
Coaches: Chris Allen and Kamran Atabai
Judith Hellman (faculty)
"The Toxic Avenger: Mopping up Sepsis."
Kang JH et al. An extracorporeal blood-cleansing device for sepsis therapy. Nat Med. 2014 Oct;20(10):1211-6. doi:10.1038/nm.3640
December 11, 2014
Vassily Kutyavin (student)
"Mitochondrial respiration sustains cancer relapse."
Viale A, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014; 514: 628-632.
Coaches: Scott Kogan and Eric Snyder
Nancy Boudreau (faculty)
Sherman et al., Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy. Cell 2014 Sept. 1;159(1):80-93. http://dx.doi.org/10.1016/j.cell.2014.08.007
December 18, 2014
Aaron Mattingly (student)
"Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A."
Fledrich R et al., Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat Med. 2014 Sep;20(9):1055-61. doi: 10.1038/nm.3664
Coaches: Sarah Knox, Jeff Bush and Allan Basbaum
Adam Ferguson (faculty)
"Thrash Metal and Neurotrauma: Intracellular iron and TNF bias macrophage polarization toward an M1 phenotype in spinal cord injury."
Kroner et al., TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord. Neuron, September 3, 2014; 83:1098–1116. dx.doi.org/10.1016/j.neuron.2014.07.027
January 8, 2015
Melissa Ng (student)
"Shape matters - DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity."
Zhang Q et al., DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med 2014 Nov 24;211:2549-2566.
Coaches: Cliff Lowell and Mike Rosenblum
Trevor Burt (faculty)
"Inflammation plays a role in definitive hematopoiesis."
Espín-Palazón R et al., Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 2014 Nov 20;159(5):1070-85. doi: 10.1016/j.cell.2014.10.031. Epub 2014 Nov 6.
January 15, 2015
KT Nguyen (student)
"Attack of the Human Invaders: Engrafted Human Glial Progenitors Display A Competitive Advantage in Mice Brains."
Windrem MS et al., A Competitive Advantage by Neonatally Engrafted Human Glial Progenitors Yields Mice Whose Brains Are Chimeric for Human Glia. J. Neurosci. 2014 Nov 26;34(48):16153-16161.
Coaches: Jonah Chan and Steve Fancy
Kamran Atabai (faculty)
"ECM activates postitive feedback loop."
Parker MW et al., Fibrotic extracellular matrix activates a profibrotic positive feedback loop. J Clin Invest. 2014;124(4):1622–1635. doi:10.1172/JCI71386.
January 22, 2015
*Special Time - 5:00 pm.*
Yvanka De Soysa (student)
"R"evolutionary" Heart Regeneration: miR-ly Taking After The Zebrafish."
Aguirre A et al., In Vivo Activation of a Conserved MicroRNA Program Induces Mammalian Heart Regeneration. Cell Stem Cell 2014; 15:589-604.
Coaches: Deepak Srivastava and Daniel Hart
Kevin Shannon (faculty)
"Two hits are better than one in tumorigenesis."
De Raedt et al., PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 2014 Oct 9;514(7521):247-51. doi: 10.1038/nature13561
January 29, 2015
Rachel O'Keefe (student)
"With a Little Help from My(eloid) Friends: Secretion of IL-1RA by myeloid cells protects tumor cells from senescence."
Di Mitri D et al., Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. Nature. 2014 Nov 6;515(7525):134-7. doi: 10.1038/nature13638.
Coaches: Martin McMahon and Lawrence Fong
Elad Ziv (faculty)
"Silent, but deadly: Synonymous mutations as drivers in cancer."
Supek et al., Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers. Cell 13 March 2014; 156:1324-1335. dx.doi.org/10.1016/j.cell.2014.01.051
February 5, 2015
*Special Time - 5:00 p.m.*
Annalise Petriello (student)
"Mosquito’s Munch Moderated: Microbe-Derived Glycan Immunization Protects Against Malaria Infection."
Yilmaz B et al., "Gut Microbiota Elicits a Protective Immune Response Against Malaria Transmission." Cell 2014, 159(6):1277-1289.
Coaches: Margaret Feeney and Charlie Kim
Clifford Lowell (faculty)
"Checkpoint blockade for cancer immunotherapy; the most exciting stuff in BioMedical Science."
Gubin et al. (2014). Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515:577-581. doi: 10.1038/nature13988.
February 12, 2015
Pallavi Penumetcha (student)
"Adding a commensal virus to the mix: a role for murine norovirus in maintaining gut homeostasis."
Kernbauer E et al., An enteric virus can replace the beneficial function of commensal bacteria. Nature. 2014 Nov 19. doi: 10.1038/nature13960
Prescott Woodruff (faculty)
"Birds of a feather don't always fly together."
Becattini S et al., Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines. Science. 2014 Dec 4. pii: 1260668.
February 19, 2015
Meera Shenoy (student)
"Interfer(on)ing with the Succession: Non-epithelial Type I Interferon Response Increases Epithelial Turnover and Repair during Chronic Viral Infection."
Sun et al. (2015). Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair. Cell Host & Microbe, 17(1):85–97. dx.doi.org/10.1016/j.chom.2014.11.004
Coaches: Shomi Sanjabi and Mike Rosenblum
Mark Looney (faculty)
"Tickle me PINK1: Swollen mitochondria and lung fibrosis."
Bueno M et al. (2015), PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015;125(2):521–538. doi:10.1172/JCI74942.
February 26, 2015
Dan Holohan (student)
"Better Than OK Cupid: Profiling Desirable Single Cells Using CytoSeq."
Fan CH et al. (2015), Combinatorial labeling of single cells for gene expression cytometry. Science 347(6222):1258367-1-8. doi: 10.1126/science.1258367.
Coaches: Alex Marson and Michael McManus
John Fahy (faculty)
"Maybe one size does not fit all - the Mepolizumab story in asthma."
Ortega H et al. (2014). Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 371(13):1198-207.
March 5, 2015
Alice Taubes (student)
"Thinking ahead: Hippocampal theta sequences reflect current goals."
Wikenhaiser AM and Redish AD (2015). Hippocampal theta sequences reflect current goals. Nature Neurosciences. 18:289-894.
Coaches: Yadong Huang and Alexandra Nelson
Shaun Coughlin (faculty)
"Are hemostasis and thrombosis always two sides of the same coin, or is lunch ever free?"
Larsson M et al. (2014) A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk. Sci. Transl. Med. 6, 222ra17. doi: 10.1126/scitranslmed.3006804
March 12, 2015
Yixuan Wu (student)
"A Series of Fortunate Events: Loss of a Mutant CXCR4 Allele by Chromosomal Shattering Cures Congenital Disease."
McDermott et al., 2015. Chromothriptic Cure of WHIM Syndrome. Cell. 160: 686-699.
Coaches: Cliff Lowell and Joseph Shieh
Erik Ullian (faculty)
"Small Glia Found in Unexpected Places."
Elmore et al. (2014), Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014 Apr 16;82(2):380-97. doi: 10.1016/j.neuron.2014.02.040.
March 19, 2015
Yang Zhang (student)
"Complement Left Bugs A Mark for Rapid Intracellular Pathogen Sensing."
Tam JC et al. (2014) Intracellular sensing of complement C3 activates cell autonomous immunity. Science. 2014 Sep 5;345(6201):1256070. doi: 10.1126/science.1256070
Coaches: Jason Cyster and Tony DeFranco
(no faculty speaker this week)
March 26, 2015
Mario Zubia (student)
"The double-edged sword of inflammation in neurodegeneration: How reducing inflammation can worsen Alzheimer's disease."
Chakrabarty P et al. (2015) IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior. Neuron 85:519-533.
Coaches: Susanna Rosi and Yadong Huang
Jeanne Paz (faculty)
"Epilepsy controlled from a distance."
Krook-Magnuson E et al. (2014). Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy. eNeuro, 2014 December; 1(1) doi:10.1523/ENEURO.0005-14.2014
April 2, 2015
Emily Jones (student)
"Diapers for Dendrites: how a superabsorbant compound can achieve superresolution in 3D."
Chen F et al. (2015). Expansion microscopy. Science, 347:543-548. doi: 10.1126/science.1260088.
Coaches: Yadong Huang and Aimee Kao
Laurence Cheng (faculty)
"Triple Threat: IL-3 promotes the development of sepsis."
Weber GF et al. (2015) Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science 347, 1260. doi: 10.1126/science.aaa4268
April 9, 2015
Natanya Kerper (student)
"Wnt On, Wnt Off: Ascl2 controls intestinal stemness via a Wnt-responsive and Wnt-dependent autoregulatory loop."
Schuijers et al. (2015). Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts. Cell Stem Cell 16:158–170. dx.doi.org/10.1016/j.stem.2014.12.006
Coaches: Ophir Klein and TBD
Francesca Aloisio (student)
"m6Agnificent mRNA methylation: Facilitating differentiation by epigenetic modification of mRNA."
Geula S et al. (2015). m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science 347(6225):1002-1006.
Coaches: Diane Barber and Rob Judson
April 16, 2015
Abby Kindberg (student)
"Remyelination to the rescue? hESC derived oligodendrocytes rescue cognitive deficits following radiation therapy."
Piao J et al. (2015). Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitors Remyelinate the Brain and Rescue Behavioral Deficits following Radiation. Cell Stem Cell 16(2):198–210.
Coaches: Susanna Rosi and Steve Fancy
Qi Yan Ang (student)
"Role of IL-33 in regulating Treg homeostasis in visceral adipose tissue."
Vasanthakumar A et al. (2015) The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells. Nature Immunology, 16(3):276-85. doi:10.1038/ni.3085
Coaches: Suneil Koliwad and Ari Molofsky
April 23, 2015
Erick Lu (student)
"It's leaking! DNA damage activates the STING pathway: Insights into Ataxia-telangiectasia."
Härtlova et al., 2015. DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity. Immunity 42, 332–343. dx.doi.org/10.1016/j.immuni.2015.01.012
Coaches: Jason Cyster and Matthias Wabl
Dror Assa (student)
"I Scream, You Scream, We All Scream for Colitis and Metabolic Syndrome."
Chassaing et al., 2015. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 519(7541):92-6. doi:10.1038/nature14232
Coaches: Peter Turnbaugh and Leor Weinberger
April 30, 2015
Andrew Mancini (student)
"Promoting immortality: TERT promoter mutations in urothelial cancer."
Borah S et al., (2015) TERT promoter mutations and telomerase reactivation in urothelial cancer. Science. 347(6225):1007-1010.
Coaches: Joe Costello, Kyle Walsh and Aaron Diaz
Adair Borges (student)
“Biphotonic laser-assisted surgery tool: BLASTing into the future of cellular engineering.”
Wu YC et al., Massively parallel delivery of large cargo into mammalian cells with light pulses. Nat Methods. 2015 Apr 6. doi: 10.1038/nmeth.3357.
Coaches: Shaeri Mukherjee and Alex Marson
May 7, 2015
Ariel Kauss (student)
Ubil E et al., Mesenchymal–endothelial transition contributes to cardiac neovascularization. Nature. 2014 Oct 30;514(7524):585-90. doi:10.1038/nature13839
Coaches: Rik Derynck and Allan Balmain
Nyasha Chagwedera (student)
Wensveen FM et al. (2015) NK cells link obesity-induced adipose stress to inflammation and insulin resistance. Nat Immunol. 16(4):376-85. doi: 10.1038/ni.3120. Epub 2015 Mar 2.
May 14, 2015
Elze Rackaityte (student)
Stacey Frumm (student)
Obenauf et al., Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 2015 Apr 16; 520(7547):368-72. doi: 10.1038/nature14336
May 21, 2015
Luke Smith (student)
John Gagnon (student)
Metzger MJ et al., 2015, Horizontal Transmission of Clonal Cancer Cells Causes Leukemia in Soft-Shell Clams. Cell 161, 255–263. dx.doi.org/10.1016/j.cell.2015.02.042
May 28, 2015
May Szeto (student)
Caroline Gleason (student)
June 4, 2015
Corey Tan (student)
Bernadette Hsu (student)
June 11, 2015
Eric Wigton (student)
Jorge Ortiz-Carpena (student)