BMS Journal Club
September 5, 2013-June 12, 2014
Journal Club Chairs: Mike German, MD and Brad Stohr, MD, PhD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room GH-S271, Mission Bay
Live stream & archive: Fall 2013 (UCSF MyAccess login required)
September 05, 2013
Christina Hueschen (student)
"How to get a-head in life: Rescuing head regrowth in regeneration-limited planarians"
Liu SY, et al. Reactivating head regrowth in a regeneration-deficient planarian species. Nature. 2013 Aug 1;500(7460):81-4.
Coaches: Jeremy Reiter and Arnold Kriegstein
Chris Allen (faculty)
"Dangerous cleavage: allergen activation of innate immunity"
Millien VO, et al. Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4. Science. 2013 Aug 16;341(6147):792-6.
September 12, 2013
Aude Bouagnon (student)
"Live long and prosper: Mitonuclear protein imbalance as a conserved longevity mechanism"
Houtkooper RH, et al. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature. 2013 May 23;497(7450):451-7.
Coaches: Kaveh Ashrafi and Aimee Kao
Bob Farese (faculty)
"A chance to cut is a chance to cure: How does the surgery on the gut cure diabetes?"
Saeidi N, et al. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science. 2013 Jul 26;341(6144):406-10.
September 19, 2013
Brittany Gianetti (student)
Eskandarian HA, et al. A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. Science. 2013 Aug 2;341(6145):1238858.
Coaches: Suzanne Noble, Joanne Engel, and Anna Bakardjiev
Terren Niethamer (student)
"Finding the "Rett" Answer: A suppressor screen to identify pathways of disease pathogenesis in Rett syndrome"
Buchovecky CM, et al. A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet. 2013 Aug 28;45(9):1013-20.
Coaches: Elliott Sherr and Doug Gould
September 26, 2013
Carlos Rojo (student)
"Adding in-salt to injury: tissue damage detection by osmotic surveillance"
Enyedi B, et al. Tissue damage detection by osmotic surveillance. Nat Cell Biol. 2013 Sep;15(9):1123-30.
Coaches: Daniel Hart and De'Broski Herbert
De'Broski Herbert (faculty)
"The painful necessity of inflammation"
Chiu, Isaac M., et al. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 2013/08/21
October 03, 2013
Emily Tang (student)
"Clostridia cocktail to suppress inflammation"
Atarashi K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013 Aug 8;500(7461):232-6.
Coaches: Susan Lynch and Averil Ma
Scott Seeley (faculty)
"Stuck in traffic: Endocytic defects and the development of myeloid leukemia"
Nagamachi A, et al. Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17.
October 10, 2013
Juliet Goldsmith (student)
Curry NL, et al. Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction. Cancer Discov. 2013 Aug;3(8):908-921.
Coaches: Trever Bivona, Eric Collisson and Jay Debnath
Melissa McCreery (student)
"Genetic Signatures of Cancer and Implications for Personalized Medicine"
Ciriello G, et al. Emerging landscape of oncogenic signatures across human cancers. Nat Genet. 2013 Sep 26;45(10):1127-1133.
Coaches: Allan Balmain and TBD
October 17, 2013
David Pardo (student)
"Blurred lines in epidermal wounding but not homeostasis"
Page ME, et al. The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations. Cell Stem Cell. 2013 Oct 3;13(4):471-482.
Coaches: Todd Nystul and Jason Rock
Marta Margeta (faculty)
"A double-edged sword: How interplay of host defense systems can lead to disease"
Ichimura Y, et al. Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy. Mol Cell. 2013 Sep 12;51(5):618-31.
October 24, 2013
Kurt Weiberth (student)
"I'll Take That: PolyQ Proteins Sequester Sis1p and Impair Nuclear Degradation of Cytosolic Proteins"
Sae-Hun Park, et al. PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone. Cell, Volume 154, Issue 1, 3 July 2013, Pages 134–145.
Coaches: Doug Gould and Jason Gestwicki
Eric Dang (student)
"Lin(c)ing RNA to Innate Immune Activation"
Carpenter S et al. A Long Noncoding RNA mediates both Activation and Repression of Immune Response Genes. Science. 2013 Aug 16;341(6147):789-92. doi: 10.1126/science.1240925. Epub 2013
Coaches: Mark Ansel and Mark Anderson
October 31, 2013
Kamena Kostova (student)
"Mutant mice from MIT: One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering"
Yang H, et al. One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering. Cell. 2013 Sep 12;154(6):1370-9. doi: 10.1016/j.cell.2013.08.022. Epub 2013 Aug 29. PubMed PMID: 23992847
Coaches: Martin McMahon and Davide Ruggero
Manish Aghi (faculty)
"Trick or Treat: Dual Functions of CDK6 link the cell cycle to angiogenesis"
Kollmann K, et al.A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cell. 2013 Aug 12;24(2):167-81.
November 07, 2013
TJ Hu (student)
Christianson HC, et al. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci U S A. 2013 Oct 7.
Coaches: Jay Debnath and Steve Rosen
Michael Rosenblum (faculty)
"Not in my house! - Tregs provide a safe haven for stem cells…"
Fujisaki J, et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature. 2011 Jun 8;474(7350):216-9.
November 14, 2013
Alex Samocha (student)
"Mind the GAP! The RasGAP gene, RASAL2, is a tumor and metastasis suppressor"
McLaughlin SK, et al. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell. 2013 Sep 9;24(3):365-78.
Coaches: Jeroen Roose and Scott Oakes
Susan Fisher (faculty)
"Mucus as a Mediator"
Shan M, et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science. 2013 Oct 25;342(6157):447-53.
November 21, 2013
Dana Neel (student)
"The MLLephant in the room: MLL fusion proteins require NF-kB for leukemogenesis"
Kuo HP, et al. Epigenetic Roles of MLL Oncoproteins Are Dependent on NF-κB. Cancer Cell. 2013 Oct 14;24(4):423-37.
Coaches: Neil Shah and Ben Braun
Roger Chang (student)
"The Itchy and Scratchy Show: TSLP and Itch Neurons"
Wilson SR, et al. The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch. Cell. 2013 Oct 10;155(2):285-95.
Coaches: Anatol Kreitzer and Roger Nicoll
December 05, 2013
Arman Jahangiri (student)
"The Few, The Proud, The Cancer Cells That Survive Metastasis"
Shibue T, et al. An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell. 2013 Oct 14;24(4):481-98.
Jinwoo Lee (student)
"PI3King on PIDs: Using Exome Sequencing to Identify Novel Disease-Causing Mutations"
Angulo I, et al. Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science. 2013 Nov 15;342(6160):866-71.
Coaches: Art Weiss and Jennifer Puck
December 12, 2013
Daniel Holohan (student)
"The mystery of Themis in thymus: controlling selection of low-affinity TCRs during T cell development"
Fu G, et al. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature. 2013 Nov 13.
Coaches: Jeroen Roose and Art Weiss
Thomas Hennings (student)
"Insulin's long lost cousin leptin: leptin maintains life through the hypothalamus in the absence of insulin"
Fujikawa T, et al. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013 Sep 3;18(3):431-44.
Coaches: Allison Xu and Shingo Kajimura
January 09, 2014
Yuchen Gao (student)
Briana Fitch (student)
January 16, 2014
Jillian Jespersen (student)
Andrew Lechner (student)
Böiers C, et al. Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells. Cell Stem Cell. 2013 Nov 7;13(5):535-48.
January 23, 2014
Evan Markegard (student)
Faculty TBD (faculty)
January 30, 2014
John Liu (student)
Misty Montoya (student)
February 06, 2014
Samira Khakpour (student)
Max Krummel (faculty)
February 13, 2014
Dylan Lowe (student)
Linda Noble (faculty)
February 20, 2014
Jerome Kahiapo (student)
Sarah Knox (faculty)
February 27, 2014
Kelly Remedios (student)
Melissa Sandoval (student)
March 06, 2014
Mark Noviski (student)
Ethan Weiss (faculty)
March 13, 2014
Stephanie Moquin (student)
Phil Nova (student)
March 20, 2014
Joe Udeochu (student)
Robert Nissenson (faculty)
April 03, 2014
Roman Camarda (student)
Yvanka De Soysa (student)
April 10, 2014
Lindsey Jones (student)
Annalise Petriello (student)
April 17, 2014
James Jung (student)
Meera Shenoy (student)
April 24, 2014
Vassily Kutyavin (student)
Dimitre Simeonov (student)
May 01, 2014
Christina Adams (student)
Melissa Spear (student)
May 08, 2014
Ibraheem Ali (student)
Adrienne Stormo (student)
May 15, 2014
Tim Marsh (student)
Alice Taubes (student)
May 22, 2014
Aaron Mattingly (student)
Yixuan Wu (student)
May 29, 2014
Melissa Ng (student)
Yang Zhang (student)
June 05, 2014
KT Nguyen (student)
Mario Zubia (student)
June 12, 2014
Rachel O'Keefe (student)
Pallavi Penumetcha (student)