BMS Journal Club
September 4, 2014-June 11, 2015
Journal Club Chairs: Mike German, MD and Suzanne Noble, MD, PhD
Day/Time: Thursdays, 12:00-1:00 p.m. except as noted
Location: N-225, Parnassus & videoconferenced to Room MH-1405, Mission Bay.
Live stream & archive: Spring 2015, Winter 2015, Fall 2014, Summer 2014 (9/4 and 9/11) (UCSF MyAccess login required)
September 04, 2014
Adrienne Stormo (student)
"Hunting for a Mechanism: Mutant Huntingtin Inhibits Mitochondrial Protein Import in Huntington's Disease"
Yano H, et al., Inhibition of mitochondrial protein import by mutant huntingtin. Nature Neuroscience 2014, 17:822–831.
Coaches: Ken Nakamura and Scott Oakes
Aimee Kao (faculty)
"A breath of fresh air before complete destruction: A new pathway for lysosomal clearance of misfolded proteins"
Satpute-Krishnan et al., ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway. Cell 2014, 158:522–533.
September 11, 2014
Melissa Spear (student)
"This Little Piggy: Defective mucus clearance is primary cause of lung disease in piglet model of cystic fibrosis"
Hoegger MJ, et al., Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis. Science 2014, 345(6198):818-822.
Coaches: John Fahy and Jason Rock
Leor Weinberger (faculty)
"Fast and Efficient: HIV latency establishment in vivo"
Whitney JB et al., Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 2014, 512(7512):74-7.
September 18, 2014
Mission Bay videoconference: MH-1405
Tim Marsh (student)
"Myc's Side-Kicks: A Lnc to Tumorigenesis"
Tseng YY et al., PVT1 dependence in cancer with MYC copy-number increase. Nature Letters 2014, 512:82-86.
Coaches: Michael McManus and Jay Debnath
Guo Huang (faculty)
"Chasing Mysterious Adult Mammalian Cardiac Stem Cell"
van Berlo et al., c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature 2014, 509:337-341.
"Throwing the β-globin locus for a loop"
Deng W et al., Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 2014 Aug 14;158(4):849-60. doi: 10.1016/j.cell.2014.05.050.
Coaches: Alex Marson and Michael McManus
Bassem Al-Sady (faculty)
“How your grandkids know what you ate (or didn’t)”
Rechavi O et al., Starvation-induced transgenerational inheritance of small RNAs in C. elegans. Cell. 2014 Jul 17;158(2):277-87. doi: 10.1016/j.cell.2014.06.020.
October 02, 2014
Mission Bay videoconference: MH-1405
Christina Adams (student)
“Breaking up is hard to do: Cytokinesis failure leads to tetraploidy and Hippo pathway activation”
Ganem et al., Cytokinesis Failure Triggers Hippo
Tumor Suppressor Pathway Activation. Cell 2014, 158:833-848
Coaches: Scott Seeley and Andrei Goga
Raymond Swanson (faculty)
"Microglial stripping: a NOXious way to learn."
Zhang et al., Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase. Neuron 2014, 82:195-207.
October 9, 2014
Ibraheem Ali (student)
"A Small Stop to the Nonsense of Mutations."
Zhao et al., MicroRNA-mediated repression of nonsense mRNAs. eLife 2014;3:e03032. DOI: 10.7554/eLife.03032
Coaches: Mark Ansel and Michael McManus
Emin Maltepe (faculty)
"Livin' the High Life - Beef up that PHD."
Lorenzo FR et al., A genetic mechanism for Tibetan high-altitude adaptation. Nat. Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067.
October 16, 2014
Roman Camarda (student)
"If you bind it, allosteric regulation will come"
Sureka et al., The Cyclic Dinucleotide c-di-AMP Is an Allosteric Regulator of Metabolic Enzyme Function. Cell 2014, 158:1389–1401, http://dx.doi.org/10.1016/j.cell.2014.07.046
Coaches: Andrei Goga and Joanne Engel
Miguel Ramalho-Santos (faculty)
"Passive aggressive sex: 'Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote.'"
Guo et al., Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote. Cell Stem Cell. 2014 Oct 2;15(4):447-58. doi: 10.1016/j.stem.2014.08.003
October 23, 2014
Biao Wang (faculty)
“White fat browning is UP to stomach and brain.”
Ruan HB et al., O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell. 2014 Oct 9;159(2):306-17. doi: 10.1016/j.cell.2014.09.010.
David Erle (faculty)
"Sending a message: Promoters direct traffic during cell stress"
Zid BM and O’Shea EK. Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast. Nature 2014 Oct 2;514(7520):117-21. doi: 10.1038/nature13578.
October 30, 2014
Briana Fitch (student)
"Attack of the clones: Long-lived progenitor clones drive hematopoiesis."
Sun et al., Clonal dynamics of native haematopoiesis. Nature, 2014 Oct 5. doi:10.1038/nature13824
Coaches: Scott Kogan and Ann Zovein
Shaeri Mukherjee (faculty)
"Simple steps that lead to the removal of misfolded proteins from the ER."
Stein A et al., Key Steps in ERAD of Luminal ER Proteins Reconstituted with Purified Components. Cell. 2014 Sep 11;158(6):1375-88. doi: 10.1016/j.cell.2014.07.050.
November 06, 2014
Tommy Hennings (student)
"Foxy organ! Pancreatic β-cell function involves more than one FoxO factor."
Kim-Muller J et al. Metabolic Inflexibility Impairs Insulin Secretion and Results in MODY-like Diabetes in Triple FoxO-Deficient Mice. Cell Metabolism 2014 October 7; 20:593-602. http://dx.doi.org/10.1016/j.cmet.2014.08.012
Coaches: Julie Sneddon and Greg Ku
Jeoung-Sook Shin (faculty)
"TCR signaling fuels Treg cell suppressor function."
Levine et al., Continuous requirement for the TCR in regulatory T cell function. Nat Immunol. 2014 Sep 28. doi: 10.1038/ni.3004.
November 13, 2014
Jillian Jespersen (student)
"Opposing roles of two miRNAs: counter-regulation of follicular helper T cells during chronic inflammation."
Hu et al., miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014 Oct 16. doi:10.1016/j.immuni.2014.09.015
Coaches: Mehrdad Matloubian and Michael McManus
Paolo Rinaudo (faculty)
"Even the youngest ones have such an amazing memory!"
Rexhaj E et al., Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span. J Clin Invest. 2013 Dec 2;123(12):5052-60. doi: 10.1172/JCI68943
November 20, 2014
Lindsey Jones (student)
"CRISPRing our way to novel murine models of cancer."
Xue W et al., CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 514:380-384, 2014 October 16. Doi:10.1038/nature13589
Coaches: Joe Costello and Andrei Goga
"Sister chromatids: Moving apart or together?"
Sarangapani KK et al. Sister kinetochores are mechanically fused during meiosis I in yeast. Science. 2014 Oct 10;346(6206):248-51. doi: 10.1126/science.1256729.
December 4, 2014
James Jung (student)
"Pulmonary macrophage transplantation therapy."
Suzuki, T., et al., Pulmonary macrophage transplantation therapy. Nature 2014, October 23. 514:450-454. doi:10.1038/nature13807
Coaches: Chris Allen and Kamran Atabai
Judith Hellman (faculty)
"The Toxic Avenger: Mopping up Sepsis."
Kang JH et al. An extracorporeal blood-cleansing device for sepsis therapy. Nat Med. 2014 Oct;20(10):1211-6. doi:10.1038/nm.3640
December 11, 2014
Vassily Kutyavin (student)
"Mitochondrial respiration sustains cancer relapse."
Viale A, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014; 514: 628-632.
Coaches: Scott Kogan and Eric Snyder
Nancy Boudreau (faculty)
Sherman et al., Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy. Cell 2014 Sept. 1;159(1):80-93. http://dx.doi.org/10.1016/j.cell.2014.08.007
December 18, 2014
Aaron Mattingly (student)
"Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A."
Fledrich R et al., Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat Med. 2014 Sep;20(9):1055-61. doi: 10.1038/nm.3664
Coaches: Sarah Knox, Jeff Bush and Allan Basbaum
Adam Ferguson (faculty)
"Thrash Metal and Neurotrauma: Intracellular iron and TNF bias macrophage polarization toward an M1 phenotype in spinal cord injury."
Kroner et al., TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord. Neuron, September 3, 2014; 83:1098–1116. dx.doi.org/10.1016/j.neuron.2014.07.027
January 8, 2015
Melissa Ng (student)
Trevor Burt (faculty)
January 15, 2015
KT Nguyen (student)
Kamran Atabai (faculty)
January 22, 2015
*Special Time - 5:00 pm.*
Yvanka De Soysa (student)
Alan Ashworth (faculty)
January 29, 2015
Rachel O'Keefe (student)
Elad Ziv (faculty)
February 5, 2015
*Special Time - 5:00 p.m.*
Annalise Petriello (student)
faculty TBD (faculty)
February 12, 2015
Pallavi Penumetcha (student)
Kernbauer E et al., An enteric virus can replace the beneficial function of commensal bacteria. Nature. 2014 Nov 19. doi: 10.1038/nature13960
Prescott Woodruff (faculty)
February 19, 2015
Meera Shenoy (student)
Mark Looney (faculty)
February 26, 2015
Dan Holohan (student)
John Fahy (faculty)
March 5, 2015
Alice Taubes (student)
Shaun Coughlin (faculty)
March 12, 2015
Yixuan Wu (student)
Erik Ullian (faculty)
March 19, 2015
Yang Zhang (student)
Jae Woo Lee (faculty)
March 26, 2015
Mario Zubia (student)
Jeanne Paz (faculty)
April 2, 2015
Emily Jones (student)
Laurence Cheng (faculty)
April 9, 2015
Natanya Kerper (student)
Francesca Aloisio (student)
April 16, 2015
Abby Kindberg (student)
Qi Yan Ang (student)
April 23, 2015
Erick Lu (student)
Dror Assa (student)
"The Bitter End of Artificial Sweeteners?"
Suez et al., Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Sep 17. doi: 10.1038/nature13793
April 30, 2015
Andrew Mancini (student)
Adair Borges (student)
May 7, 2015
Ariel Kauss (student)
Nyasha Chagwedera (student)
May 14, 2015
Elze Rackaityte (student)
Stacey Frumm (student)
May 21, 2015
Luke Smith (student)
John Gagnon (student)
May 28, 2015
May Szeto (student)
Caroline Gleason (student)
June 4, 2015
Corey Tan (student)
Bernadette Hsu (student)
June 11, 2015
Eric Wigton (student)
Jorge Ortiz-Carpena (student)