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Ying-Hui Fu, PhD

Ying-Hui Fu, PhD
Professor , Neurology
Research Summary:

Molecular understanding of human sleep behaviors

We are interested in gaining a molecular understanding of human sleep behavior traits including sleep schedule and sleep duration. We use technologies and methodologies ranging from human genetics, mouse modeling, molecular cellular biology, biochemistry, to system neuroscience in order to help us unravel how human sleep behaviors are regulated at the molecular and system levels. Ultimately, we hope to use this information and knowledge to improve human sleep conditions and qualities.

Selected Publications

Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptáček LJ, Fu Y-H. An hPer2 phosphorylation site mutation in familial advanced sleep-phase syndrome. Science. 2001;291:1040-3.

Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptáček LJ, Fu Y-H. Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome. Nature. 2005;434:640-4.

Padiath QS, Saigoh K, Schiffman R, Asahara H, Koeppen A, Hogan K, Ptáček LJ, Fu Y-H. Lamin B1 duplications cause autosomal dominant leukodystrophy. Nat Genet. 2006 Oct ; 38(10)1114-23. Epub 2006 Sep 3.

Xu Y, Toh KL, Jones CR, Shin JY, Fu Y-H, Ptáček LJ. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. 2007 Jan 12:128(1):59-70.

Lin S-T and Fu Y-H. miR-23 Regulation of Lamin B1 is Critical for Oligodendrocyte Development and Myelination. Disease Model and Mechanism 2009 2:178-188.

He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. The transcriptional repressor DEC2 regulates sleep length in mammals. Science 2009 325:866.

Shin D, Shin J, McManus MT, Ptáček LJ, and Fu Y-H. Dicer Ablation in Oligodendrocytes Provokes Neuronal Iimpairment in Mice. Annal Neurology 2009, 66(6):843-57.

Kategaya L, Hilliard A, Zhang L, Asara JM, Ptáček LJ and Fu Y-H. Casein Kinase 1 Temporal Proteomics Reveal Prohibitin 2 Function in Molecular Clock. PLos ONE. 2012; 7(2):e31987.

Shin D, Howng SY, Ptáček LJ, Fu Y-H. miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. Neuroscience. 2012 Jun 28; 213:29-37.  

Zhang L, Abraham D, Nishino S, Oster H, Fujiki N, Gregor Eichele, Fu Y-H, Ptáček LJ. PKCγ Participates in the Entrainment of the Cerebral Circadian Clocks by Feeding. Proc Natl Acad Sci USA. 2012 Dec 11;109(50):20679-84.

Kaasik K, Kivimae S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu Y-H. Glucose Sensor O-GlycNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock. Cell Metab. 2013 Feb 5;17(2): 291-302.

Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee H-Y, Jones CR, Fu Y-H, Charles AC, Ptáček LJ. Casein kinase Iδ mutations in familial migraine and advanced sleep phase. Science Translational Medicine. 2013 May 1;5(183):183ra53.

Heng MY, Lin S-T, Verret L, Huang Y, Kamiya S, Palop JJ, Huang EJ, Ptáček LJ, Fu Y-H. Lamin B1 Mediates Cell-Autonomous Neuropathology in a Leukodystrophy Mouse Model. J Clin Invest. 2013 Jun 1: 123(6):2719-29.

Lin S-T, Huang Y, Zhang L, Heng M, Ptáček LJ, Fu Y-H. miR-23a Promotes Myelination in the Central Nervous System. Proc Natl Acad Sci USA. 2013 Oct 22;110(43):17468-73.

Lin S-T, Zhang L, Lin X, Zhang LC, Garcia VE, Tsai CW, Ptáček LJ, Fu Y-H*. Nuclear envelope protein MAN1 regulates clock through BMAL1. Elife. 2014 Sep 2;3:e02981.